RTW INVESTMENTS, LP

13D and 13G Filings

Investors who own more than 5% of a class must file a Schedule 13D or 13G. The latest filing for each security since 12/18/2024, newest first.

Issuer	Symbol	CUSIP	% of Class	Shares	Form	Filed
Allurion Technologies, Inc. 13D/A ALURD · 02008G300	ALURD	02008G300	9.9%	67,441	13D/A	9/2/2026 Event 8/31/2026
RTW Investments, LP			9.9%	67,441
Roderick Wong			9.9%	67,441
uniQure N.V. 13G QURE · N90064101	QURE	N90064101	5.7%	3,941,572	13G	8/14/2026 Event 6/30/2026
RTW Investments, LP			5.7%	3,941,572
Roderick Wong			5.7%	3,941,572
Ultragenyx Pharmaceutical Inc. 13G RARE · 90400D108	RARE	90400D108	7.9%	7,796,895	13G	8/14/2026 Event 6/30/2026
RTW Investments, LP			7.9%	7,796,895
Roderick Wong			7.9%	7,796,895
Tenax Therapeutics, Inc. 13G/A TENX · 88032L605	TENX	88032L605	9.9%	2,866,654	13G/A	8/14/2026 Event 6/30/2026
RTW Investments, LP			9.9%	2,866,654
Roderick Wong			9.9%	2,866,654
Spyre Therapeutics, Inc. 13G/A SYRE · 00773J202	SYRE	00773J202	4.8%	4,251,996	13G/A	8/14/2026 Event 6/30/2026
RTW Investments, LP			4.8%	4,251,996
Roderick Wong			4.8%	4,251,996
RadNet, Inc. 13G/A RDNT · 750491102	RDNT	750491102	6.2%	4,846,958	13G/A	8/14/2026 Event 6/30/2026
RTW Investments, LP			6.2%	4,846,958
Roderick Wong			6.2%	4,846,958
Oruka Therapeutics, Inc. 13G ORKA · 687604108	ORKA	687604108	5.2%	3,139,030	13G	8/14/2026 Event 6/30/2026
RTW Investments, LP			5.2%	3,139,030
Roderick Wong			5.2%	3,139,030
Kailera Therapeutics, Inc. 13G KLRA · 482931102	KLRA	482931102	8.3%	10,776,820	13G	8/14/2026 Event 6/30/2026
RTW Investments, LP			8.3%	10,776,820
Roderick Wong			8.3%	10,776,820
iRhythm Holdings, Inc. 13G/A IRTC · 450056106	IRTC	450056106	6.6%	2,182,631	13G/A	8/14/2026 Event 6/30/2026
RTW Investments, LP			6.6%	2,182,631
Roderick Wong			6.6%	2,182,631
CG Oncology, Inc. 13G/A CGON · 156944100	CGON	156944100	9.7%	8,514,590	13G/A	8/14/2026 Event 6/30/2026
RTW Investments, LP			9.7%	8,514,590
Roderick Wong			9.7%	8,514,590
Verastem, Inc. 13G/A VSTM · 92337C203	VSTM	92337C203	9.9%	9,018,724	13G/A	5/15/2026 Event 3/31/2026
RTW Investments, LP			9.9%	9,018,724
Roderick Wong			9.9%	9,018,724
Taysha Gene Therapies, Inc. 13G/A TSHA · 877619106	TSHA	877619106	7.0%	20,689,084	13G/A	5/15/2026 Event 3/31/2026
RTW Investments, LP			7.0%	20,689,084
Roderick Wong			7.0%	20,689,084
Tango Therapeutics, Inc. 13G TNGX · 87583X109	TNGX	87583X109	9.3%	13,300,620	13G	5/15/2026 Event 3/31/2026
RTW Investments, LP			9.3%	13,300,620
Roderick Wong			9.3%	13,300,620
Stoke Therapeutics, Inc. 13G/A STOK · 86150R107	STOK	86150R107	9.9%	5,940,866	13G/A	5/15/2026 Event 3/31/2026
RTW Investments, LP			9.9%	5,940,866
Roderick Wong			9.9%	5,940,866
Replimune Group, Inc. 13G/A REPL · 76029N106	REPL	76029N106	8.9%	7,356,916	13G/A	5/15/2026 Event 3/31/2026
RTW Investments, LP			8.9%	7,356,916
Roderick Wong			8.9%	7,356,916
Rapt Therapeutics, Inc. 13G/A RAPT · 75382E208	RAPT	75382E208	0%	0	13G/A	5/15/2026 Event 3/31/2026
RTW Investments, LP			0%	0
Roderick Wong			0%	0
Milestone Pharmaceuticals Inc. 13G/A MIST · 59935V107	MIST	59935V107	9.9%	12,356,953	13G/A	5/15/2026 Event 3/31/2026
RTW Investments, LP			9.9%	12,356,953
Roderick Wong			9.9%	12,356,953
Immatics N.V. 13G/A IMTX · N44445109	IMTX	N44445109	9.6%	12,869,340	13G/A	5/15/2026 Event 3/31/2026
RTW Investments, LP			9.6%	12,869,340
Roderick Wong			9.6%	12,869,340
Erasca, Inc. 13G ERAS · 29479A108	ERAS	29479A108	5.2%	16,157,175	13G	5/15/2026 Event 3/31/2026
RTW Investments, LP			5.2%	16,157,175
Roderick Wong			5.2%	16,157,175
COMPASS Pathways plc 13G/A CMPS · 20451W101	CMPS	20451W101	9.9%	12,971,571	13G/A	5/15/2026 Event 3/31/2026
RTW Investments, LP			9.9%	12,971,571
Roderick Wong			9.9%	12,971,571
Century Therapeutics, Inc. 13G IPSC · 15673T100	IPSC	15673T100	7.1%	13,043,478	13G	5/15/2026 Event 3/31/2026
RTW Investments, LP			7.1%	13,043,478
Roderick Wong			7.1%	13,043,478
Celcuity Inc. 13G CELC · 15102K100	CELC	15102K100	6.3%	3,039,621	13G	5/15/2026 Event 3/31/2026
RTW Investments, LP			6.3%	3,039,621
Roderick Wong			6.3%	3,039,621
Castle Biosciences, Inc. 13G/A CSTL · 14843C105	CSTL	14843C105	9.3%	2,758,335	13G/A	5/15/2026 Event 3/31/2026
RTW Investments, LP			9.3%	2,758,335
Roderick Wong			9.3%	2,758,335
Candel Therapeutics, Inc. 13G CADL · 137404109	CADL	137404109	8.8%	6,422,018	13G	5/15/2026 Event 3/31/2026
RTW Investments, LP			8.8%	6,422,018
Roderick Wong			8.8%	6,422,018
Beta Bionics, Inc. 13G/A BBNX · 08659B102	BBNX	08659B102	4.5%	2,000,000	13G/A	5/15/2026 Event 3/31/2026
RTW Investments, LP			4.5%	2,000,000
Roderick Wong			4.5%	2,000,000
Apellis Pharmaceuticals, Inc. 13G/A APLS · 03753U106	APLS	03753U106	2.9%	3,685,045	13G/A	5/15/2026 Event 3/31/2026
RTW Investments, LP			2.9%	3,685,045
Roderick Wong			2.9%	3,685,045
Orchestra Biomed Holdings, Inc. 13D/A OBIO · 68572M106	OBIO	68572M106	19.2%	11,942,394	13D/A	4/29/2026 Event 4/27/2026
RTW Investments, LP			19.2%	11,942,394
RTW Master Fund, Ltd.			9.6%	5,820,915
RTW Innovation Master Fund, Ltd.			8.1%	4,931,714
Roderick Wong			19.2%	11,942,394
Allurion Technologies, Inc. 13D/A ALUR · 02008G201	ALUR	02008G201	39.4%	5,891,430	13D/A	3/2/2026 Event 2/26/2026
RTW Investments, LP			39.4%	5,891,430
RTW Master Fund, Ltd.			21.0%	3,138,798
RTW Innovation Master Fund, Ltd.			16.2%	2,427,089
Roderick Wong			39.4%	5,891,430
Zai Lab Limited 13G ZLAB · 98887Q104	ZLAB	98887Q104	6.3%	69,590,320	13G	2/17/2026 Event 12/31/2025
RTW Investments, LP			6.3%	69,590,320
Roderick Wong			6.3%	69,590,320
SAB Biotherapeutics, Inc. 13G/A SABS · 78397T202	SABS	78397T202	3.2%	1,587,302	13G/A	2/17/2026 Event 12/31/2025
RTW Investments, LP			3.2%	1,587,302
Roderick Wong			3.2%	1,587,302
Protagonist Therapeutics, Inc 13G/A PTGX · 74366E102	PTGX	74366E102	8.1%	5,059,053	13G/A	2/17/2026 Event 12/31/2025
RTW Investments, LP			8.1%	5,059,053
Roderick Wong			8.1%	5,059,053
Kalaris Therapeutics, Inc. 13G KLRS · 482929106	KLRS	482929106	5.7%	1,300,000	13G	2/17/2026 Event 12/31/2025
RTW Investments, LP			5.7%	1,300,000
Roderick Wong			5.7%	1,300,000
Exagen Inc. 13G/A XGN · 30068X103	XGN	30068X103	4.9%	1,148,768	13G/A	2/17/2026 Event 12/31/2025
RTW Investments, LP			4.9%	1,148,768
Roderick Wong			4.9%	1,148,768
Apogee Therapeutics, Inc. 13G/A APGE · 03770N101	APGE	03770N101	4.9%	2,712,097	13G/A	2/17/2026 Event 12/31/2025
RTW Investments, LP			4.9%	2,712,097
Roderick Wong			4.9%	2,712,097
Alector, Inc. 13G/A ALEC · 014442107	ALEC	014442107	0%	0	13G/A	2/17/2026 Event 12/31/2025
RTW Investments, LP			0%	0
Roderick Wong			0%	0
Akero Therapeutics, Inc. 13G/A AKRO · 00973Y108	AKRO	00973Y108	0%	0	13G/A	2/17/2026 Event 12/31/2025
RTW Investments, LP			0%	0
Roderick Wong			0%	0
Xencor Inc 13G XNCR · 98401F105	XNCR	98401F105	8.7%	6,221,054	13G	11/14/2025 Event 9/30/2025
RTW Investments, LP			8.7%	6,221,054
Roderick Wong			8.7%	6,221,054
Merus N.V. 13G/A MRUS · N5749R100	MRUS	N5749R100	2.7%	2,025,277	13G/A	11/14/2025 Event 9/30/2025
RTW Investments, LP			2.7%	2,025,277
Roderick Wong			2.7%	2,025,277
Cargo Therapeutics, Inc. 13G/A CRGX · 14179K101	CRGX	14179K101	0%	0	13G/A	11/14/2025 Event 9/30/2025
RTW Investments, LP			0%	0
Roderick Wong			0%	0
Aquestive Therapeutics, Inc. 13G AQST · 03843E104	AQST	03843E104	5.2%	6,250,000	13G	11/14/2025 Event 9/30/2025
RTW Investments, LP			5.2%	6,250,000
Roderick Wong			5.2%	6,250,000
Acadia Pharmaceuticals Inc. 13G/A ACAD · 004225108	ACAD	004225108	4.2%	7,144,524	13G/A	11/14/2025 Event 9/30/2025
RTW Investments, LP			4.2%	7,144,524
Roderick Wong			4.2%	7,144,524
Avidity Biosciences, Inc. 13D/A RNAM · 05370A108	RNAM	05370A108	3.1%	4,686,110	13D/A	10/29/2025 Event 10/27/2025
RTW Investments, LP			3.1%	4,686,110
Roderick Wong			3.1%	4,686,110
Compass Therapeutics, Inc. 13G/A CMPS · 20451W101	CMPS	20451W101	0%	0	13G/A	8/14/2025 Event 6/30/2025
RTW Investments, LP			0%	0
Roderick Wong			0%	0
Tarsus Pharmaceuticals, Inc. 13G/A TARS · 87650L103	TARS	87650L103	8.1%	3,424,180	13G/A	8/14/2025 Event 6/30/2025
RTW Investments, LP			8.1%	3,424,180
Roderick Wong			8.1%	3,424,180
Axsome Therapeutics, Inc. 13G/A AXSM · 05464T104	AXSM	05464T104	3.1%	1,516,903	13G/A	8/14/2025 Event 6/30/2025
RTW Investments, LP			3.1%	1,516,903
Roderick Wong			3.1%	1,516,903
89bio, Inc. 13G/A ETNB · 282559103	ETNB	282559103	1.3%	1,967,527	13G/A	5/15/2025 Event 3/31/2025
RTW Investments, LP			1.3%	1,967,527
Roderick Wong, M.D.			1.3%	1,967,527
GH Research PLC 13G/A GHRS · G3855L106	GHRS	G3855L106	8.9%	5,499,769	13G/A	5/15/2025 Event 3/31/2025
RTW Investments, LP			8.9%	5,499,769
Roderick Wong, M.D.			8.9%	5,499,769
PepGen Inc. 13G/A PEPG · 713317105	PEPG	713317105	0%	0	13G/A	5/15/2025 Event 3/31/2025
RTW Investments, LP			0%	0
Roderick Wong, M.D.			0%	0
Dyne Therapeutics, Inc. 13G/A DYN · 26818M108	DYN	26818M108	1.5%	1,690,567	13G/A	5/15/2025 Event 3/31/2025
RTW Investments, LP			1.5%	1,690,567
Roderick Wong, M.D.			1.5%	1,690,567
Immunic, Inc. 13G/A IMUX · 4525EP101	IMUX	4525EP101	1.1%	1,026,762	13G/A	5/15/2025 Event 3/31/2025
RTW Investments, LP			1.1%	1,026,762
Roderick Wong, M.D.			1.1%	1,026,762
Rapt Therapeutics, Inc. 13G RAPT · 75382E109 Amended under CUSIP 75382E208 on 5/15/2026	RAPT	75382E109	8.9%	11,764,000	13G	5/15/2025 Event 3/31/2025
RTW Investments, LP			8.9%	11,764,000
Roderick Wong, M.D.			8.9%	11,764,000
Allurion Technologies, Inc. 13D/A ALUR · 02008G102 Amended under CUSIP 02008G201 on 4/17/2025	ALUR	02008G102	17.6%	1,050,053	13D/A	2/24/2025 Event 2/20/2025
RTW Investments, LP			17.6%	1,050,053
RTW Master Fund, Ltd.			8.4%	501,806
RTW Innovation Master Fund, Ltd.			6.6%	395,328
Roderick Wong, M.D.			17.6%	1,050,053
Neurogene Inc. 13G/A NGNE · 64135M105	NGNE	64135M105	10.0%	1,498,829	13G/A	2/14/2025 Event 12/31/2024
RTW Investments, LP			10.0%	1,498,829
Roderick Wong, M.D.			10.0%	1,498,829
Establishment Labs Holdings Inc. 13G/A ESTA · G31249108	ESTA	G31249108	10.0%	2,822,216	13G/A	2/14/2025 Event 12/31/2024
RTW Investments, LP			10.0%	2,822,216
Roderick Wong, M.D.			10.0%	2,822,216
ESSA Pharma Inc. 13G/A EPIX · 29668H708	EPIX	29668H708	2.5%	1,113,002	13G/A	2/14/2025 Event 12/31/2024
RTW Investments, LP			2.5%	1,113,002
Roderick Wong, M.D.			2.5%	1,113,002
Geron Corporation 13G/A GERN · 374163103	GERN	374163103	0%	0	13G/A	2/14/2025 Event 12/31/2024
RTW Investments, LP			0%	0
Roderick Wong, M.D.			0%	0
Cutera, Inc. 13G/A CUTRQ · 232109108	CUTRQ	232109108	0%	0	13G/A	2/14/2025 Event 12/31/2024
RTW Investments, LP			0%	0
Roderick Wong, M.D.			0%	0
Sage Therapeutics, Inc. 13G/A SAGE · 78667J108	SAGE	78667J108	4.9%	3,002,370	13G/A	2/14/2025 Event 12/31/2024
RTW Investments, LP			4.9%	3,002,370
Roderick Wong, M.D.			4.9%	3,002,370