Investors who own more than 5% of a class must file a Schedule 13D or 13G. Each filer's latest filing for 517125100 since 12/18/2024, largest first.
| Filer | % of Class | Filed | ||
|---|---|---|---|---|
|
James E. Flynn
13D/A
|
34.4% |
3/2/2026
Event 2/27/2026
|
||
| Deerfield Private Design Fund III, L.P. | 10.3% | |||
| Deerfield Healthcare Innovations Fund, L.P. | 7.9% | |||
| Deerfield Private Design Fund IV, L.P. | 10.3% | |||
| Deerfield Partners, L.P. | 6.0% | |||
| Deerfield Mgmt III, L.P. | 10.3% | |||
| Deerfield Mgmt HIF, L.P. | 7.9% | |||
| Deerfield Mgmt IV, L.P. | 10.3% | |||
| Deerfield Mgmt, L.P. | 6.0% | |||
| Deerfield Management Company, L.P. | 34.4% | |||
| James E. Flynn | 34.4% | |||
| Blue Owl Capital Holdings LP 13G/A | 10.0% |
5/14/2026
Event 3/31/2026
|
||
| Under 5%, checked the "5 percent or less" box, or amended by a later filing (6) | ||||
|
Opaleye Management Inc.
13G
|
4.8% |
8/29/2025
Event 8/29/2025
|
||
| Opaleye Management, Inc. | 4.8% | |||
| Opaleye, L.P. | 4.8% | |||
| James Silverman | 4.8% | |||
| BlackRock, Inc. 13G/A | 4.8% |
4/22/2025
Event 3/31/2025
|
||
|
Goldman Sachs Group Inc
13G/A
|
4.1% |
5/13/2025
Event 3/31/2025
|
||
| The Goldman Sachs Group, Inc. | 4.1% | |||
| Goldman Sachs & Co. LLC | 4.1% | |||
|
Millennium Management LLC
13G/A
|
3.5% |
4/30/2026
Event 3/31/2026
|
||
| Millennium Management LLC | 3.5% | |||
| Millennium Group Management LLC | 3.5% | |||
| Israel A. Englander | 3.5% | |||
| Janus Henderson Group PLC 13G/A | 0% |
8/14/2025
Event 3/31/2025
|
||
|
RA Capital Management, L.P.
13G/A
|
0% |
2/17/2026
Event 12/31/2025
|
||
| RA Capital Management, L.P. | 0% | |||
| Peter Kolchinsky | 0% | |||
| Rajeev Shah | 0% | |||
| RA Capital Healthcare Fund, L.P. | 0% | |||
| Period | Filings | Shares, Excl. Options | Value, Excl. Options |
|---|---|---|---|
| 2026 Q3 | 2 | 6.14 k | $19.6 k |
| 2026 Q2 | 171 | 95.5 M | $293 M |
| 2026 Q1 | 171 | 87.8 M | $395 M |
| 2025 Q4 | 140 | 72.7 M | $277 M |
| 2025 Q3 | 154 | 85.5 M | $275 M |
| 2025 Q2 | 127 | 62.4 M | $180 M |
| 2025 Q1 | 109 | 60.8 M | $132 M |
| 2024 Q4 | 125 | 63.4 M | $245 M |
| 2024 Q3 | 130 | 64.4 M | $421 M |
| 2024 Q2 | 116 | 65.4 M | $474 M |
| 2024 Q1 | 119 | 63.8 M | $484 M |
| 2023 Q4 | 78 | 39.7 M | $181 M |
| 2023 Q3 | 70 | 38.8 M | $153 M |
| 2023 Q2 | 68 | 39.0 M | $120 M |
| 2023 Q1 | 71 | 38.5 M | $174 M |
| 2022 Q4 | 51 | 38.8 M | $160 M |
| 2022 Q3 | 63 | 40.9 M | $131 M |
| 2022 Q2 | 42 | 14.4 M | $28.2 M |
| 2022 Q1 | 49 | 15.3 M | $61.8 M |
| 2021 Q4 | 51 | 14.7 M | $158 M |
| 2021 Q3 | 56 | 14.5 M | $167 M |
| 2021 Q2 | 47 | 14.5 M | $143 M |
| 2021 Q1 | 58 | 14.1 M | $206 M |
| 2020 Q4 | 44 | 14.3 M | $305 M |
| 2020 Q3 | 39 | 13.6 M | $207 M |
| 2020 Q2 | 38 | 13.0 M | $166 M |