RA CAPITAL MANAGEMENT, L.P.

13F Portfolio Filings

Most recent 13F: Q2 2026
13D/G filings: 13D on 29 securities, 13G on 94 securities
Location: Boston, MA
CIK: 0001346824
Alternate names: RA CAPITAL MANAGEMENT, LLC
All SEC filings: View on sec.gov

Holdings Value

Quarter	Holdings	Value ($000)	Top Holdings	Form Type	Date Filed	Filing ID
Q2 2026	84	11,507,522	ASND, PBLS, RYTM, PCVX	13F-HR	8/14/2026	000110465926097251
Q1 2026	85	9,437,744	ASND, PCVX, RYTM, TYRA	13F-HR	5/15/2026	000110465926062637
Q4 2025	71	9,760,868	ASND, CDTX, RYTM, RNAM	13F-HR	2/17/2026	000110465926016482
Q3 2025	67	8,115,527	ASND, RYTM, PCVX, RNAM	13F-HR	11/14/2025	000110465925112469
Q2 2025	63	5,935,681	ASND, PCVX, RYTM, JANX	13F-HR	8/14/2025	000110465925078691
Q1 2025	85	5,987,912	ASND, PCVX, RYTM, JANX	13F-HR	5/15/2025	000110465925049549
Q4 2024	89	7,514,204	ASND, PCVX, JANX, RYTM	13F-HR	2/14/2025	000110465925014181
Q3 2024	81	8,673,579	ASND, PCVX, JANX, LEGN	13F-HR	11/14/2024	000110465924119034
Q2 2024	78	7,560,766	ASND, PCVX, JANX, LEGN	13F-HR	8/14/2024	000110465924089629
Q1 2024	1	61,347	CGON	NEW HOLDINGS	5/17/2024	000110465924063050
Q1 2024	75	7,798,795	ASND, PCVX, LEGN, JANX	13F-HR	5/15/2024	000110465924062062
Q4 2023	62	6,402,499	ASND, IMGN, PCVX, LEGN	13F-HR	2/14/2024	000110465924023984
Q3 2023	1	37,587	CTKB	NEW HOLDINGS	11/15/2023	000110465923118452
Q3 2023	65	5,042,131	ASND, LEGN, PCVX, IMGN	13F-HR	11/14/2023	000110465923118214
Q2 2023	54	5,296,462	ASND, LEGN, PCVX, DICE	13F-HR	8/14/2023	000110465923091405
Q1 2023	59	4,417,403	ASND, PCVX, DICE, ETNB	13F-HR	5/15/2023	000110465923060785
Q4 2022	70	4,930,699	ASND, PCVX, AVTE, DICE	13F-HR	2/14/2023	000110465923021847
Q3 2022	81	4,687,527	ASND, BIIB, CTKB, FMTX	13F-HR	11/14/2022	000110465922118654
Q2 2022	88	3,750,535	ASND, BIIB, CTKB, AVTE	13F-HR	8/15/2022	000110465922091331
Q1 2022	96	4,583,149	ASND, BIIB, AVTE, CTKB	13F-HR	5/16/2022	000110465922061386
Q4 2021	97	5,671,942	ASND, NVAX, ITOS, TVTX	13F-HR	2/14/2022	000110465922022807
Q3 2021	95	7,216,744	ASND, NVAX, CLYM, IVVD	13F-HR	11/15/2021	000110465921139249
Q2 2021	92	6,230,450	ASND, NVAX, FMTX, JANX	13F-HR	8/16/2021	000110465921106386
Q1 2021	82	6,631,817	ASND, NVAX, VOR, AVIR	13F-HR	5/17/2021	000110465921068149
Q4 2020	82	7,153,595	ASND, TGTX, NVAX, NKTX	13F-HR	2/16/2021	000110465921024161
Q3 2020	70	5,467,231	ASND, FMTX, CCXI, PCVX	13F-HR	11/16/2020	000110465920125858
Q2 2020	57	5,131,829	ASND, FMTX, NVAX, CCXI	13F-HR	8/14/2020	000110465920095562
Q1 2020	48	3,165,729	ASND, RARX, CCXI, ARVN	13F-HR	5/15/2020	000110465920062663
Q4 2019	34	3,297,714	THOR, ASND, RARX, ARVN	13F-HR	2/14/2020	000110465920021928
Q3 2019	32	1,678,386	ASND, WVE, THOR, RARX	13F-HR	11/14/2019	000110465919064263
Q2 2019	25	1,862,830	ASND, WVE, ZGNX, RARX	13F-HR	8/14/2019	000114420419040093
Q1 2019	29	2,319,025	ASND, WVE, THOR, ZGNX	13F-HR	5/15/2019	000114420419026610
Q4 2018	25	1,717,985	WVE, ASND, THOR, ZGNX	13F-HR	2/14/2019	000114420419008235
Q3 2018	26	1,870,521	WVE, ASND, SLDB, ECYT	13F-HR	11/14/2018	000114420418059977
Q2 2018	27	1,540,247	WVE, ASND, SLDB, ECYT	13F-HR	8/14/2018	000114420418044712
Q1 2018	31	1,305,208	WVE, ASND, AVXS, MYOV	13F-HR	5/15/2018	000114420418028896
Q4 2017	27	1,195,149	WVE, ASND, AVXS, SAGE	13F-HR	2/14/2018	000114420418008963
Q3 2017	27	1,106,912	ASND, WVE, AVXS, BHVN	13F-HR	11/14/2017	000114420417059064
Q2 2017	22	871,430	ASND, WVE, AVXS, ACHN	13F-HR	8/14/2017	000114420417043212
Q1 2017	24	815,257	WVE, ASND, AVXS, ACHN	13F-HR	5/15/2017	000114420417027535
Q4 2016	26	687,184	WVE, ASND, AVXS, ACHN	RESTATEMENT	2/16/2017	000114420417009568
Q4 2016	1	18,660	MYOV	NEW HOLDINGS	2/16/2017	000114420417009569
Q3 2016	31	969,369	WVE, ACHN, ASND, AVXS	13F-HR	11/14/2016	000114420416134325
Q2 2016	32	722,235	WVE, ACHN, AXGT, AVXS	13F-HR	8/15/2016	000114420416119492
Q1 2016	42	782,348	WVE, ACHN, AXGT, ACRS	13F-HR	5/16/2016	000114420416102679
Q4 2015	37	1,010,538	ACHN, WVE, DYAX, AXGT	13F-HR	2/16/2016	000114420416082766
Q3 2015	47	696,301	ACHN, AXGT, DYAX, COLL	13F-HR	11/13/2015	000114420415065340
Q2 2015	59	994,105	AXGT, ACHN, DYAX, SGMOQ calls	13F-HR	8/13/2015	000114420415049028
Q1 2015	57	1,006,949	SGMOQ calls, ACHN, DYAX, BCRX	RESTATEMENT	7/6/2015	000114420415041113
Q4 2014	51	930,497	SGMOQ calls, BCRX, ACHN, RGLS	13F-HR	2/17/2015	000114420415010101
Q3 2014	46	846,275	ACAD calls, DYAX, BCRX, ACHN	13F-HR	11/14/2014	000114420414068823
Q2 2014	28	989,267	ACHN, ACAD calls, DYAX, SGMOQ calls	13F-HR	8/14/2014	000114420414050172
Q1 2014	35	1,394,409	GILD puts, ACAD calls, SGMOQ calls, SGMOQ	13F-HR	5/15/2014	000114420414031040
Q4 2013	31	858,468	ACAD calls, ACHN, SGMOQ, TXMD	13F-HR	2/14/2014	000114420414009252

Additional filings from Ra Capital Management, L.P. that have since been restated

13D and 13G Filings

All 13D and 13G filings

Investors who own more than 5% of a class must file a Schedule 13D or 13G. Each security where the latest filing since 12/18/2024 is a 13D, newest first.

Issuer	Symbol	CUSIP	% of Class	Shares	Form	Filed
Sionna Therapeutics, Inc. 13D/A SION · 829401108	SION	829401108	14.3%	6,476,193	13D/A	9/21/2026 Event 9/17/2026
RA Capital Management, L.P.			14.3%	6,476,193
Peter Kolchinsky			14.3%	6,476,193
Rajeev Shah			14.3%	6,476,193
RA Capital Healthcare Fund, L.P.			7.6%	3,448,812
RA Capital Nexus Fund III, L.P.			4.9%	2,198,082
Tyra Biosciences, Inc. 13D/A TYRA · 90240B106	TYRA	90240B106	19.9%	14,130,492	13D/A	9/17/2026 Event 9/15/2026
RA Capital Management, L.P.			19.9%	14,130,492
Peter Kolchinsky			19.9%	14,130,492
Rajeev Shah			19.9%	14,130,492
RA Capital Healthcare Fund, L.P.			17.2%	12,115,875
Septerna, Inc. 13D/A SEPN · 81734D104	SEPN	81734D104	11.8%	5,525,324	13D/A	8/14/2026 Event 8/12/2026
RA Capital Management, L.P.			11.8%	5,525,324
Peter Kolchinsky			11.8%	5,525,324
Rajeev Shah			11.8%	5,525,324
RA Capital Healthcare Fund, L.P.			10.2%	4,777,415
Wave Life Sciences, Inc. 13D/A WVE · 94352A104	WVE	94352A104	16.8%	34,314,406	13D/A	8/11/2026 Event 8/7/2026
RA Capital Management, L.P.			16.8%	34,314,406
Peter Kolchinsky			16.8%	34,314,406
Rajeev Shah			16.8%	34,314,406
RA Capital Healthcare Fund, L.P.			16.7%	34,069,161
SAB Biotherapeutics, Inc. 13D/A SABS · 78397T202	SABS	78397T202	9.9%	9,609,852	13D/A	8/10/2026 Event 8/6/2026
RA Capital Management, L.P.			9.9%	9,609,852
Peter Kolchinsky			9.9%	9,609,852
Rajeev Shah			9.9%	9,609,852
RA Capital Healthcare Fund, L.P.			9.9%	9,609,852
Artiva Biotherapeutics, Inc. 13D/A ARTV · 04317A107	ARTV	04317A107	37.9%	18,415,956	13D/A	7/23/2026 Event 7/22/2026
RA Capital Management, L.P.			37.9%	18,415,956
Peter Kolchinsky			37.9%	18,415,956
Rajeev Shah			37.9%	18,415,956
RA Capital Healthcare Fund, L.P.			35.5%	17,242,483
Freenome, Inc. 13D/A FRNM · 35661P100	FRNM	35661P100	14.3%	15,367,270	13D/A	7/22/2026 Event 7/20/2026
RA Capital Management, L.P.			14.3%	15,367,270
Peter Kolchinsky			14.3%	15,367,270
Rajeev Shah			14.3%	15,367,270
RA Capital Healthcare Fund, L.P.			11.4%	12,230,122
Vor Biopharma Inc. 13D/A VOR · 929033207	VOR	929033207	19.9%	12,937,855	13D/A	7/21/2026 Event 7/16/2026
RA Capital Management, L.P.			19.9%	12,937,855
Peter Kolchinsky			19.9%	12,937,855
Rajeev Shah			19.9%	12,937,855
RA Capital Healthcare Fund, L.P.			19.9%	12,931,166
Climb Bio, Inc. 13D/A CLYM · 28658R106	CLYM	28658R106	33.0%	23,249,186	13D/A	7/7/2026 Event 7/2/2026
RA Capital Management, L.P.			33.0%	23,249,186
Peter Kolchinsky			33.0%	23,249,186
Rajeev Shah			33.0%	23,249,186
RA Capital Healthcare Fund, L.P.			24.1%	16,934,205
RA Capital Nexus Fund III, L.P.			6.4%	3,671,766
Solid Biosciences Inc. 13D/A SLDB · 83422E204	SLDB	83422E204	11.9%	12,036,126	13D/A	6/24/2026 Event 6/22/2026
RA Capital Management, L.P.			11.9%	12,036,126
Peter Kolchinsky			11.9%	12,036,126
Rajeev Shah			11.9%	12,036,126
RA Capital Healthcare Fund, L.P.			11.8%	11,897,896
Parabilis Medicines, Inc. 13D PBLS · 698955101	PBLS	698955101	23.8%	28,933,371	13D	6/18/2026 Event 6/11/2026
RA Capital Management, L.P.			23.8%	28,933,371
Peter Kolchinsky			23.8%	28,933,371
Rajeev Shah			23.8%	28,933,371
RA Capital Healthcare Fund, L.P.			21.6%	26,285,093
Acrivon Therapeutics, Inc. 13D/A ACRV · 004890109	ACRV	004890109	28.8%	12,284,906	13D/A	4/23/2026 Event 4/22/2026
RA Capital Management, L.P.			28.8%	12,284,906
Peter Kolchinsky			28.8%	12,284,906
Rajeev Shah			28.8%	12,284,906
RA Capital Healthcare Fund, L.P.			27.7%	11,803,094
Wave Life Sciences Ltd. 13D/A WVE · Y95308105	WVE	Y95308105	17.1%	34,225,506	13D/A	4/17/2026 Event 4/15/2026
RA Capital Management, L.P.			17.1%	34,225,506
Peter Kolchinsky			17.1%	34,225,506
Rajeev Shah			17.1%	34,225,506
RA Capital Healthcare Fund, L.P.			17.1%	34,069,161
Acumen Pharmaceuticals, Inc. 13D/A ABOS · 00509G209	ABOS	00509G209	29.5%	21,101,669	13D/A	3/17/2026 Event 3/13/2026
RA Capital Management, L.P.			29.5%	21,101,669
Peter Kolchinsky			29.5%	21,101,669
Rajeev Shah			29.5%	21,101,669
RA Capital Healthcare Fund, L.P.			26.8%	19,103,785
Bicara Therapeutics Inc. 13D/A BCAX · 055477103	BCAX	055477103	11.5%	7,279,739	13D/A	3/2/2026 Event 2/26/2026
RA Capital Management, L.P.			11.5%	7,279,739
Peter Kolchinsky			11.5%	7,279,739
Rajeev Shah			11.5%	7,279,739
RA Capital Healthcare Fund, L.P.			7.3%	4,603,418
Evommune, Inc. 13D/A EVMN · 30054Y107	EVMN	30054Y107	9.7%	3,494,638	13D/A	2/17/2026 Event 2/12/2026
RA Capital Management, L.P.			9.7%	3,494,638
Peter Kolchinsky			9.7%	3,494,638
Rajeev Shah			9.7%	3,494,638
RA Capital Healthcare Fund, L.P.			7.5%	2,710,293
Spyglass Pharma, Inc. 13D SGP · 85220G109	SGP	85220G109	24.1%	8,022,639	13D	2/17/2026 Event 2/9/2026
RA Capital Management, L.P.			24.1%	8,022,639
Peter Kolchinsky			24.1%	8,022,639
Rajeev Shah			24.1%	8,022,639
RA Capital Healthcare Fund, L.P.			17.9%	5,966,439
RA Capital Nexus Fund III, L.P.			6.2%	2,054,678
Lenz Therapeutics, Inc. 13D/A LENZ · 52635N103	LENZ	52635N103	13.6%	4,265,106	13D/A	11/7/2025 Event 11/5/2025
RA Capital Management, L.P.			13.6%	4,265,106
Peter Kolchinsky			13.6%	4,265,106
Rajeev Shah			13.6%	4,265,106
RA Capital Healthcare Fund, L.P.			10.8%	3,373,921
Ars Pharmaceuticals, Inc. 13D/A SPRY · 82835W108	SPRY	82835W108	11.1%	10,940,977	13D/A	10/1/2025 Event 9/29/2025
RA Capital Management, L.P.			11.1%	10,940,977
Peter Kolchinsky			11.1%	10,940,977
Rajeev Shah			11.1%	10,940,977
RA Capital Healthcare Fund, L.P.			10.1%	9,958,073
Pepgen Inc. 13D/A PEPG · 713317105	PEPG	713317105	29.2%	20,099,753	13D/A	9/30/2025 Event 9/26/2025
RA Capital Management, L.P.			29.2%	20,099,753
Peter Kolchinsky			29.2%	20,099,753
Rajeev Shah			29.2%	20,099,753
RA Capital Healthcare Fund, L.P.			27.0%	18,554,273
Mineralys Therapeutics, Inc. 13D/A MLYS · 603170101	MLYS	603170101	9.9%	7,796,433	13D/A	9/8/2025 Event 9/4/2025
RA Capital Management, L.P.			9.9%	7,796,433
Peter Kolchinsky			9.9%	7,796,433
Rajeev Shah			9.9%	7,796,433
RA Capital Healthcare Fund, L.P.			7.5%	5,846,161
Vor Biopharma Inc. 13D/A VOR · 929033108	VOR	929033108	31.8%	39,739,850	13D/A	6/27/2025 Event 6/25/2025
RA Capital Management, L.P.			31.8%	39,739,850
Peter Kolchinsky			31.8%	39,739,850
Rajeev Shah			31.8%	39,739,850
RA Capital Healthcare Fund, L.P.			30.3%	37,820,713
Janux Therapeutics, Inc. 13D/A JANX · 47103J105	JANX	47103J105	19.9%	11,971,377	13D/A	3/10/2025 Event 3/6/2025
RA Capital Management, L.P.			19.9%	11,971,377
Peter Kolchinsky			19.9%	11,971,377
Rajeev Shah			19.9%	11,971,377
RA Capital Healthcare Fund, L.P.			18.2%	10,861,013
Solid Biosciences Inc. 13D/A SLDB · 83422E105	SLDB	83422E105	9.9%	7,989,820	13D/A	2/21/2025 Event 2/19/2025
RA Capital Management, L.P.			9.9%	7,989,820
Peter Kolchinsky			9.9%	7,989,820
Rajeev Shah			9.9%	7,989,820
RA Capital Healthcare Fund, L.P.			9.8%	7,823,558
Under 5%, checked the "5 percent or less" box, or amended by a later filing (5)
Werewolf Therapeutics, Inc. 13D/A HOWL · 95075A107	HOWL	95075A107	4.1%	1,985,541	13D/A	7/2/2026 Event 6/30/2026
RA Capital Management, L.P.			4.1%	1,985,541
Peter Kolchinsky			4.1%	1,985,541
Rajeev Shah			4.1%	1,985,541
RA Capital Healthcare Fund, L.P.			3.8%	1,853,646
Cidara Therapeutics, Inc. 13D/A CDTX · 171757206	CDTX	171757206	0%	0	13D/A	1/9/2026 Event 1/7/2026
RA Capital Management, L.P.			0%	0
Peter Kolchinsky			0%	0
Rajeev Shah			0%	0
RA Capital Healthcare Fund, L.P.			0%	0
Perceptive Capital Solutions Corp 13D PCSC · G70077105 Amended under CUSIP 35661P100 on 7/22/2026	PCSC	G70077105	8.4%	750,000	13D	12/12/2025 Event 12/5/2025
RA Capital Management, L.P.			8.4%	750,000
Peter Kolchinsky			8.4%	750,000
Rajeev Shah			8.4%	750,000
RA Capital Healthcare Fund, L.P.			8.4%	750,000
89BIO, Inc. 13D/A ETNB · 282559103	ETNB	282559103	0%	0	13D/A	11/3/2025 Event 10/30/2025
RA Capital Management, L.P.			0%	0
Peter Kolchinsky			0%	0
Rajeev Shah			0%	0
RA Capital Healthcare Fund, L.P.			0%	0
Iteos Therapeutics, Inc. 13D/A ITOS · 46565G104	ITOS	46565G104	4.9%	2,134,806	13D/A	5/19/2025 Event 5/15/2025
RA Capital Management, L.P.			4.9%	2,134,806
Peter Kolchinsky			4.9%	2,134,806
Rajeev Shah			4.9%	2,134,806
RA Capital Healthcare Fund, L.P.			4.4%	1,896,784

94 other securities where the latest filing is a 13G, the newest filed 9/30/2026. View all