| Quarter | Holdings | Value ($000) | Form Type | Date Filed | Filing ID | Name |
|---|---|---|---|---|---|---|
| Q3 2023 | 41 | 307,379 | 13F-HR | 11/14/2023 | 000149315223041364 | Opaleye Management Inc. |
| Q2 2023 | 47 | 418,066 | 13F-HR | 8/14/2023 | 000149315223028636 | Opaleye Management Inc. |
| Q1 2023 | 41 | 333,877 | 13F-HR | 5/15/2023 | 000149315223016769 | Opaleye Management Inc. |
| Q4 2022 | 40 | 287,572 | 13F-HR | 2/10/2023 | 000149315223004277 | Opaleye Management Inc. |
| Q3 2022 | 42 | 242,132 | 13F-HR | 11/14/2022 | 000149315222032068 | Opaleye Management Inc. |
| Q2 2022 | 47 | 221,854 | 13F-HR | 8/15/2022 | 000149315222022856 | Opaleye Management Inc. |
| Q1 2022 | 45 | 321,998 | 13F-HR | 5/16/2022 | 000149315222013764 | Opaleye Management Inc. |
| Q4 2021 | 39 | 471,486 | 13F-HR | 2/14/2022 | 000149315222004434 | Opaleye Management Inc. |
| Q3 2021 | 48 | 535,390 | 13F-HR | 11/15/2021 | 000149315221028799 | Opaleye Management Inc. |
| Q2 2021 | 48 | 602,060 | 13F-HR | 8/16/2021 | 000149315221020260 | Opaleye Management Inc. |
| Q1 2021 | 58 | 680,804 | 13F-HR | 5/17/2021 | 000149315221012017 | Opaleye Management Inc. |
| Q4 2020 | 59 | 765,570 | 13F-HR | 2/12/2021 | 000149315221003697 | Opaleye Management Inc. |
| Q3 2020 | 55 | 511,320 | 13F-HR | 11/16/2020 | 000149315220021694 | Opaleye Management Inc. |
| Q2 2020 | 48 | 495,150 | 13F-HR | 8/14/2020 | 000149315220015902 | Opaleye Management Inc. |
| Q1 2020 | 44 | 377,363 | 13F-HR | 5/15/2020 | 000149315220009140 | Opaleye Management Inc. |
| Q4 2019 | 47 | 509,651 | 13F-HR | 2/14/2020 | 000149315220002529 | Opaleye Management Inc. |
| Q3 2019 | 49 | 276,541 | 13F-HR | 11/14/2019 | 000149315219017503 | Opaleye Management Inc. |
| Q2 2019 | 43 | 328,094 | 13F-HR | 8/14/2019 | 000149315219012567 | Opaleye Management Inc. |
| Q1 2019 | 53 | 361,134 | 13F-HR | 5/15/2019 | 000149315219007425 | Opaleye Management Inc. |
| Q4 2018 | 47 | 267,975 | 13F-HR | 2/14/2019 | 000149315219002114 | Opaleye Management Inc. |
| Q3 2018 | 47 | 393,047 | 13F-HR | 11/14/2018 | 000149315218016123 | Opaleye Management Inc. |
| Q2 2018 | 36 | 386,358 | 13F-HR | 8/14/2018 | 000149315218011830 | Opaleye Management Inc. |
| Q1 2018 | 38 | 349,747 | 13F-HR | 5/14/2018 | 000149315218006822 | Opaleye Management Inc. |
| Q4 2017 | 35 | 312,298 | 13F-HR | 2/9/2018 | 000149315218001743 | Opaleye Management Inc. |
| Q3 2017 | 34 | 282,772 | 13F-HR | 11/14/2017 | 000149315217013210 | Opaleye Management Inc. |
| Q2 2017 | 41 | 239,398 | 13F-HR | 8/14/2017 | 000149315217009239 | Opaleye Management Inc. |
| Q1 2017 | 44 | 200,928 | 13F-HR | 5/15/2017 | 000149315217005196 | Opaleye Management Inc. |
| Q4 2016 | 40 | 169,717 | 13F-HR | 2/21/2017 | 000114420417010166 | Opaleye Management Inc. |
| Q3 2016 | 44 | 191,082 | 13F-HR | 11/14/2016 | 000154692716000542 | Opaleye Management Inc. |
| Q2 2016 | 49 | 149,709 | RESTATEMENT | 8/12/2016 | 000154692716000514 | Opaleye Management Inc. |
| Q2 2016 | 49 | 149,709 | 13F-HR | 8/12/2016 | 000154692716000512 | Opaleye Management Inc. |
| Q1 2016 | 52 | 160,362 | RESTATEMENT | 5/27/2016 | 000154692716000499 | Opaleye Management Inc. |
| Q1 2016 | 50 | 158,625 | 13F-HR | 5/16/2016 | 000154692716000493 | Opaleye Management Inc. |
| Q4 2015 | 53 | 239,178 | 13F-HR | 2/12/2016 | 000154692716000408 | Opaleye Management Inc. |
| Q3 2015 | 49 | 203,221 | 13F-HR | 11/13/2015 | 000154692715000281 | Opaleye Management Inc. |
| Q2 2015 | 46 | 251,326 | 13F-HR | 8/14/2015 | 000154692715000231 | Opaleye Management Inc. |
| Q1 2015 | 37 | 215,386 | 13F-HR | 5/15/2015 | 000154692715000149 | Opaleye Management Inc. |
| Q4 2014 | 36 | 197,898 | 13F-HR | 2/13/2015 | 000154692715000070 | Opaleye Management Inc. |
| Q3 2014 | 30 | 128,295 | 13F-HR | 11/14/2014 | 000154692714000196 | Opaleye Management Inc. |
| Q2 2014 | 27 | 115,981 | 13F-HR | 8/14/2014 | 000154692714000159 | Opaleye Management Inc. |
| Q1 2014 | 30 | 135,373 | 13F-HR | 5/15/2014 | 000154692714000115 | Opaleye Management Inc. |
| Q4 2013 | 23 | 127,387 | 13F-HR | 2/14/2014 | 000154692714000060 | Opaleye Management Inc. |