Opaleye Management Inc.

13D and 13G Filings

Issuer	Symbol	CUSIP	% of Class	Shares	Form	Filed
Schedule 13G · 18 securities · passive
Codexis, Inc. 13G/A CDXS · 192005106	CDXS	192005106	2.4%	2,590,000	13G/A	11/6/2026 Event 9/30/2026
Opaleye Management Inc.			2.4%	2,590,000
Opaleye, L.P.			2.4%	2,590,000
James Silverman			2.4%	2,590,000
Eton Pharmaceuticals, Inc. 13G/A ETON · 29772L108	ETON	29772L108	8.5%	2,440,000	13G/A	11/6/2026 Event 9/30/2026
Opaleye Management Inc.			8.5%	2,440,000
Opaleye, L.P.			8.5%	2,420,000
Silverman James			8.5%	2,440,000
Sol-Gel Technologies Ltd 13G/A SLGL · M8694L137	SLGL	M8694L137	16.5%	540,000	13G/A	11/6/2026 Event 9/30/2026
Opaleye Management Inc.			16.5%	540,000
Opaleye, L.P.			16.0%	525,000
James Silverman			16.5%	540,000
Pasithea Therapeutics Corp. 13G/A KTTA · 70261F202	KTTA	70261F202	0%	0	13G/A	11/6/2026 Event 9/30/2026
Opaleye Management Inc.			0%	0
Opaleye, L.P.			0%	0
James Silverman			0%	0
Harrow, Inc. 13G/A HROW · 415858109	HROW	415858109	5.6%	2,105,000	13G/A	11/6/2026 Event 9/30/2026
Opaleye Management Inc.			5.6%	2,105,000
Opaleye, L.P.			5.6%	2,105,000
James Silverman			5.6%	2,105,000
Gossamer Bio, Inc. 13G/A GOSS · 38341P201	GOSS	38341P201	7.0%	426,989	13G/A	11/6/2026 Event 9/30/2026
Opaleye Management Inc.			7.0%	426,989
Opaleye, L.P.			6.8%	415,000
James Silverman			7.0%	426,989
Q32 Bio Inc. 13G/A QTTB · 746964105	QTTB	746964105	3.8%	1,120,000	13G/A	11/6/2026 Event 9/30/2026
Opaleye Management Inc.			3.8%	1,120,000
Opaleye, L.P.			3.8%	1,120,000
James Silverman			3.8%	1,120,000
Grace Therapeutics, Inc. 13G GRCE · 00439U104	GRCE	00439U104	13.1%	2,748,392	13G	8/7/2026 Event 8/5/2026
Opaleye Management Inc.			13.1%	2,748,392
Opaleye, L.P.			13.1%	2,748,392
James Silverman			13.1%	2,748,392
SANUWAVE Health, Inc. 13G/A SNWV · 80303D305	SNWV	80303D305	3.6%	309,948	13G/A	7/31/2026 Event 6/30/2026
Opaleye Management Inc.			3.6%	309,948
Opaleye, L.P.			3.6%	309,948
James Silverman			3.6%	309,948
Gossamer Bio, Inc. 13G GOSS · 38341P102 Amended under CUSIP 38341P201 on 11/6/2026	GOSS	38341P102	5.1%	24,942,565	13G	7/29/2026 Event 7/22/2026
Opaleye Management Inc.			5.1%	24,942,565
Opaleye, L.P.			4.9%	24,141,629
James Silverman			5.1%	24,942,565
Alpha Cognition Inc. 13G/A ACOG · 02074J501	ACOG	02074J501	14.2%	3,095,193	13G/A	7/24/2026 Event 7/23/2026
Opaleye Management Inc.			14.2%	3,095,193
Opaleye, L.P.			13.8%	2,995,193
James Silverman			14.2%	3,095,193
Rezolute, Inc. 13G/A RZLT · 76200L309	RZLT	76200L309	6.6%	6,300,000	13G/A	5/11/2026 Event 3/31/2026
Opaleye Management Inc.			6.6%	6,300,000
Opaleye, L.P.			6.4%	6,165,000
James Silverman			6.6%	6,300,000
Karyopharm Therapeutics Inc. 13G/A KPTI · 48576U205	KPTI	48576U205	2.7%	619,089	13G/A	5/11/2026 Event 3/31/2026
Opaleye Management Inc.			2.7%	619,089
Opaleye, L.P.			2.7%	619,089
James Silverman			2.7%	619,089
Larimar Therapeutics, Inc. 13G LRMR · 517125100	LRMR	517125100	4.8%	4,110,000	13G	8/29/2025 Event 8/29/2025
Opaleye Management, Inc.			4.8%	4,110,000
Opaleye, L.P.			4.8%	4,110,000
James Silverman			4.8%	4,110,000
Protara Therapeutics, Inc. 13G/A TARA · 74365U107	TARA	74365U107	4.7%	1,730,000	13G/A	4/28/2025 Event 3/31/2025
Ocular Therapeutix, Inc. 13G/A OCUL · 67576A100	OCUL	67576A100	2.8%	4,342,500	13G/A	2/14/2025 Event 12/31/2024
iBio, Inc. 13G/A IBIO · 451033708	IBIO	451033708	7.6%	750,000	13G/A	2/14/2025 Event 12/31/2024
Context Therapeutics Inc. 13G/A CNTX · 21077P108	CNTX	21077P108	0%	0	13G/A	2/14/2025 Event 12/31/2024

Includes filings since 12/18/2024, when the SEC began requiring structured 13D and 13G data.