Investors who own more than 5% of a class must file a Schedule 13D or 13G. Each filer's latest filing for 451033708 since 12/18/2024, largest first.
| Filer | % of Class | Filed | ||
|---|---|---|---|---|
|
Cormorant Asset Management, LP
13G/A
|
10.0% |
8/14/2026
Event 6/30/2026
|
||
| Cormorant Asset Management, LP | 10.0% | |||
| Bihua Chen | 10.0% | |||
|
Affinity Asset Advisors, LLC
13G/A
|
10.0% |
8/13/2026
Event 6/30/2026
|
||
| Affinity Asset Advisors, LLC | 10.0% | |||
| Michael Cho | 10.0% | |||
|
Adage Capital Management, L.P.
13G
|
10.0% |
11/13/2025
Event 9/30/2025
|
||
| Adage Capital Management, L.P. | 10.0% | |||
| Robert Atchinson | 10.0% | |||
| Phillip Gross | 10.0% | |||
|
SilverArc Capital Management, LLC
13G
|
10.0% |
11/14/2025
Event 9/30/2025
|
||
| SilverArc Capital Management, LLC | 10.0% | |||
| Devesh Gandhi | 10.0% | |||
| SilverArc Capital Alpha Fund II, L.P. | 7.2% | |||
|
Sirenia Capital Management LP
13G
|
9.9% |
5/15/2026
Event 3/31/2026
|
||
| Sirenia Capital Management LP | 9.9% | |||
| Alex Silverstein | 9.9% | |||
|
Vestal Point Capital, LP
13G/A
|
7.9% |
8/14/2026
Event 6/30/2026
|
||
| Vestal Point Capital, LP | 7.9% | |||
| Ryan Wilder | 7.9% | |||
| Opaleye Management Inc. 13G/A | 7.6% |
2/14/2025
Event 12/31/2024
|
||
|
Frazier Life Sciences Public Fund, L.P.
13G/A
|
5.7% |
5/12/2026
Event 3/31/2026
|
||
| Frazier Life Sciences Public Fund, L.P. | 5.7% | |||
| FHMLSP, L.P. | 5.7% | |||
| FHMLSP, L.L.C. | 5.7% | |||
| Frazier Life Sciences XI, L.P. | 0% | |||
| FHMLS XI, L.P. | 0% | |||
| FHMLS XI, L.L.C. | 0% | |||
| Frazier Life Sciences XII, L.P. | 0% | |||
| FHMLS XII, L.P. | 0% | |||
| FHMLS XII, L.L.C. | 0% | |||
|
Lynx1 Capital Management LP
13G
|
5.4% |
8/14/2026
Event 6/30/2026
|
||
| Lynx1 Capital Management LP | 5.4% | |||
| Weston Nichols | 5.4% | |||
|
Integrated Core Strategies (US) LLC
13G
|
5.2% |
1/22/2026
Event 1/15/2026
|
||
| Integrated Core Strategies (US) LLC | 5.2% | |||
| Millennium Management LLC | 5.2% | |||
| Millennium Group Management LLC | 5.2% | |||
| Israel A. Englander | 5.2% | |||
| Under 5%, checked the "5 percent or less" box, or amended by a later filing (6) | ||||
|
Ikarian Capital, LLC
13G/A
|
4.99% |
11/14/2025
Event 9/30/2025
|
||
| Ikarian Capital, LLC | 4.99% | |||
| Neil Shahrestani | 4.99% | |||
|
EcoR1 Capital, LLC
13G/A
|
4.6% |
5/15/2026
Event 3/31/2026
|
||
| EcoR1 Capital, LLC | 4.6% | |||
| Oleg Nodelman | 4.6% | |||
| EcoR1 Capital Fund Qualified, L.P. | 4.3% | |||
|
ADAR1 Capital Management, LLC
13G/A
|
4.4% |
2/17/2026
Event 12/31/2025
|
||
| ADAR1 Capital Management, LLC | 4.4% | |||
| ADAR1 Capital Management GP, LLC | 4.3% | |||
| Daniel Schneeberger | 4.4% | |||
| ADAR1 Partners, LP | 4.3% | |||
| Patrick J. Crutcher 13G/A | 3.1% |
7/30/2025
Event 6/30/2025
|
||
|
Logos Global Management LP
13G/A
|
0% |
5/15/2026
Event 3/31/2026
|
||
| Logos Global Management LP | 0% | |||
| Logos Global Management GP LLC | 0% | |||
| Logos Global Master Fund LP | 0% | |||
| Logos GP LLC | 0% | |||
| Arsani William | 0% | |||
|
Point72 Asset Management, L.P.
13G/A
|
0% |
5/15/2026
Event 3/31/2026
|
||
| Point72 Asset Management, L.P. | 0% | |||
| Point72 Capital Advisors, Inc. | 0% | |||
| Steven A. Cohen | 0% | |||
| Period | Filings | Shares, Excl. Options | Value, Excl. Options |
|---|---|---|---|
| 2026 Q2 | 55 | 34.7 M | $60.8 M |
| 2026 Q1 | 52 | 19.4 M | $36.9 M |
| 2025 Q4 | 50 | 16.3 M | $31.6 M |
| 2025 Q3 | 33 | 3.57 M | $2.96 M |
| 2025 Q2 | 31 | 3.20 M | $2.44 M |
| 2025 Q1 | 35 | 2.59 M | $10.4 M |
| 2024 Q4 | 31 | 2.61 M | $6.40 M |
| 2024 Q3 | 34 | 2.61 M | $5.79 M |
| 2024 Q2 | 32 | 2.69 M | $5.68 M |
| 2024 Q1 | 33 | 2.89 M | $11.5 M |
| 2023 Q4 | 27 | 252 k | $345 k |
| 2023 Q2 | 1 | 8.00 | $5.00 |
| 2023 Q1 | 1 | 8.00 | $17.00 |