RTW INVESTMENTS, LP

13D and 13G Filings

Investors who own more than 5% of a class must file a Schedule 13D or 13G. Every filing since 12/18/2024, newest first.

Issuer	Symbol	CUSIP	% of Class	Shares	Form	Filed
Allurion Technologies, Inc. 13D/A Amendment 13 ALURD · 02008G300	ALURD	02008G300	9.9%	67,441	13D/A Amendment 13	9/2/2026 Event 8/31/2026
RTW Investments, LP			9.9%	67,441
Roderick Wong			9.9%	67,441
uniQure N.V. 13G QURE · N90064101	QURE	N90064101	5.7%	3,941,572	13G	8/14/2026 Event 6/30/2026
RTW Investments, LP			5.7%	3,941,572
Roderick Wong			5.7%	3,941,572
Ultragenyx Pharmaceutical Inc. 13G RARE · 90400D108	RARE	90400D108	7.9%	7,796,895	13G	8/14/2026 Event 6/30/2026
RTW Investments, LP			7.9%	7,796,895
Roderick Wong			7.9%	7,796,895
Tenax Therapeutics, Inc. 13G/A Amendment 3 TENX · 88032L605	TENX	88032L605	9.9%	2,866,654	13G/A Amendment 3	8/14/2026 Event 6/30/2026
RTW Investments, LP			9.9%	2,866,654
Roderick Wong			9.9%	2,866,654
Spyre Therapeutics, Inc. 13G/A Amendment 2 SYRE · 00773J202	SYRE	00773J202	4.8%	4,251,996	13G/A Amendment 2	8/14/2026 Event 6/30/2026
RTW Investments, LP			4.8%	4,251,996
Roderick Wong			4.8%	4,251,996
RadNet, Inc. 13G/A Amendment 1 RDNT · 750491102	RDNT	750491102	6.2%	4,846,958	13G/A Amendment 1	8/14/2026 Event 6/30/2026
RTW Investments, LP			6.2%	4,846,958
Roderick Wong			6.2%	4,846,958
Oruka Therapeutics, Inc. 13G ORKA · 687604108	ORKA	687604108	5.2%	3,139,030	13G	8/14/2026 Event 6/30/2026
RTW Investments, LP			5.2%	3,139,030
Roderick Wong			5.2%	3,139,030
Kailera Therapeutics, Inc. 13G KLRA · 482931102	KLRA	482931102	8.3%	10,776,820	13G	8/14/2026 Event 6/30/2026
RTW Investments, LP			8.3%	10,776,820
Roderick Wong			8.3%	10,776,820
iRhythm Holdings, Inc. 13G/A Amendment 1 IRTC · 450056106	IRTC	450056106	6.6%	2,182,631	13G/A Amendment 1	8/14/2026 Event 6/30/2026
RTW Investments, LP			6.6%	2,182,631
Roderick Wong			6.6%	2,182,631
CG Oncology, Inc. 13G/A Amendment 1 CGON · 156944100	CGON	156944100	9.7%	8,514,590	13G/A Amendment 1	8/14/2026 Event 6/30/2026
RTW Investments, LP			9.7%	8,514,590
Roderick Wong			9.7%	8,514,590
Allurion Technologies, Inc. 13D/A Amendment 12 ALURD · 02008G300	ALURD	02008G300	9.9%	67,441	13D/A Amendment 12	7/23/2026 Event 7/21/2026
RTW Investments, LP			9.9%	67,441
Roderick Wong			9.9%	67,441
Verastem, Inc. 13G/A Amendment 3 VSTM · 92337C203	VSTM	92337C203	9.9%	9,018,724	13G/A Amendment 3	5/15/2026 Event 3/31/2026
RTW Investments, LP			9.9%	9,018,724
Roderick Wong			9.9%	9,018,724
uniQure N.V. 13G/A Amendment 4 QURE · N90064101	QURE	N90064101	4.1%	2,586,356	13G/A Amendment 4	5/15/2026 Event 3/31/2026
RTW Investments, LP			4.1%	2,586,356
Roderick Wong			4.1%	2,586,356
Tenax Therapeutics, Inc. 13G/A Amendment 2 TENX · 88032L605	TENX	88032L605	9.9%	1,867,630	13G/A Amendment 2	5/15/2026 Event 3/31/2026
RTW Investments, LP			9.9%	1,867,630
Roderick Wong			9.9%	1,867,630
Taysha Gene Therapies, Inc. 13G/A Amendment 5 TSHA · 877619106	TSHA	877619106	7.0%	20,689,084	13G/A Amendment 5	5/15/2026 Event 3/31/2026
RTW Investments, LP			7.0%	20,689,084
Roderick Wong			7.0%	20,689,084
Tango Therapeutics, Inc. 13G TNGX · 87583X109	TNGX	87583X109	9.3%	13,300,620	13G	5/15/2026 Event 3/31/2026
RTW Investments, LP			9.3%	13,300,620
Roderick Wong			9.3%	13,300,620
Stoke Therapeutics, Inc. 13G/A Amendment 7 STOK · 86150R107	STOK	86150R107	9.9%	5,940,866	13G/A Amendment 7	5/15/2026 Event 3/31/2026
RTW Investments, LP			9.9%	5,940,866
Roderick Wong			9.9%	5,940,866
Replimune Group, Inc. 13G/A Amendment 1 REPL · 76029N106	REPL	76029N106	8.9%	7,356,916	13G/A Amendment 1	5/15/2026 Event 3/31/2026
RTW Investments, LP			8.9%	7,356,916
Roderick Wong			8.9%	7,356,916
Rapt Therapeutics, Inc. 13G/A Amendment 2 RAPT · 75382E208	RAPT	75382E208	0%	0	13G/A Amendment 2	5/15/2026 Event 3/31/2026
RTW Investments, LP			0%	0
Roderick Wong			0%	0
Milestone Pharmaceuticals Inc. 13G/A Amendment 7 MIST · 59935V107	MIST	59935V107	9.9%	12,356,953	13G/A Amendment 7	5/15/2026 Event 3/31/2026
RTW Investments, LP			9.9%	12,356,953
Roderick Wong			9.9%	12,356,953
iRhythm Holdings, Inc. 13G IRTC · 450056106	IRTC	450056106	5.2%	1,668,500	13G	5/15/2026 Event 3/31/2026
RTW Investments, LP			5.2%	1,668,500
Roderick Wong			5.2%	1,668,500
Immatics N.V. 13G/A Amendment 4 IMTX · N44445109	IMTX	N44445109	9.6%	12,869,340	13G/A Amendment 4	5/15/2026 Event 3/31/2026
RTW Investments, LP			9.6%	12,869,340
Roderick Wong			9.6%	12,869,340
Erasca, Inc. 13G ERAS · 29479A108	ERAS	29479A108	5.2%	16,157,175	13G	5/15/2026 Event 3/31/2026
RTW Investments, LP			5.2%	16,157,175
Roderick Wong			5.2%	16,157,175
COMPASS Pathways plc 13G/A Amendment 2 CMPS · 20451W101	CMPS	20451W101	9.9%	12,971,571	13G/A Amendment 2	5/15/2026 Event 3/31/2026
RTW Investments, LP			9.9%	12,971,571
Roderick Wong			9.9%	12,971,571
CG Oncology, Inc. 13G CGON · 156944100	CGON	156944100	8.3%	6,984,808	13G	5/15/2026 Event 3/31/2026
RTW Investments, LP			8.3%	6,984,808
Roderick Wong			8.3%	6,984,808
Century Therapeutics, Inc. 13G IPSC · 15673T100	IPSC	15673T100	7.1%	13,043,478	13G	5/15/2026 Event 3/31/2026
RTW Investments, LP			7.1%	13,043,478
Roderick Wong			7.1%	13,043,478
Celcuity Inc. 13G CELC · 15102K100	CELC	15102K100	6.3%	3,039,621	13G	5/15/2026 Event 3/31/2026
RTW Investments, LP			6.3%	3,039,621
Roderick Wong			6.3%	3,039,621
Castle Biosciences, Inc. 13G/A Amendment 1 CSTL · 14843C105	CSTL	14843C105	9.3%	2,758,335	13G/A Amendment 1	5/15/2026 Event 3/31/2026
RTW Investments, LP			9.3%	2,758,335
Roderick Wong			9.3%	2,758,335
Candel Therapeutics, Inc. 13G CADL · 137404109	CADL	137404109	8.8%	6,422,018	13G	5/15/2026 Event 3/31/2026
RTW Investments, LP			8.8%	6,422,018
Roderick Wong			8.8%	6,422,018
Beta Bionics, Inc. 13G/A Amendment 2 BBNX · 08659B102	BBNX	08659B102	4.5%	2,000,000	13G/A Amendment 2	5/15/2026 Event 3/31/2026
RTW Investments, LP			4.5%	2,000,000
Roderick Wong			4.5%	2,000,000
Apellis Pharmaceuticals, Inc. 13G/A Amendment 1 APLS · 03753U106	APLS	03753U106	2.9%	3,685,045	13G/A Amendment 1	5/15/2026 Event 3/31/2026
RTW Investments, LP			2.9%	3,685,045
Roderick Wong			2.9%	3,685,045
Orchestra Biomed Holdings, Inc. 13D/A Amendment 7 OBIO · 68572M106	OBIO	68572M106	19.2%	11,942,394	13D/A Amendment 7	4/29/2026 Event 4/27/2026
RTW Investments, LP			19.2%	11,942,394
RTW Master Fund, Ltd.			9.6%	5,820,915
RTW Innovation Master Fund, Ltd.			8.1%	4,931,714
Roderick Wong			19.2%	11,942,394
Allurion Technologies, Inc. 13D/A Amendment 11 ALUR · 02008G201	ALUR	02008G201	39.4%	5,891,430	13D/A Amendment 11	3/2/2026 Event 2/26/2026
RTW Investments, LP			39.4%	5,891,430
RTW Master Fund, Ltd.			21.0%	3,138,798
RTW Innovation Master Fund, Ltd.			16.2%	2,427,089
Roderick Wong			39.4%	5,891,430
Orchestra Biomed Holdings, Inc. 13D/A Amendment 6 OBIO · 68572M106	OBIO	68572M106	19.7%	11,942,426	13D/A Amendment 6	2/25/2026 Event 2/23/2026
RTW Investments, LP			19.7%	11,942,426
RTW Master Fund, Ltd.			10.0%	5,820,930
RTW Innovation Master Fund, Ltd.			8.4%	4,931,727
Roderick Wong			19.7%	11,942,426
Zai Lab Limited 13G ZLAB · 98887Q104	ZLAB	98887Q104	6.3%	69,590,320	13G	2/17/2026 Event 12/31/2025
RTW Investments, LP			6.3%	69,590,320
Roderick Wong			6.3%	69,590,320
Verastem, Inc. 13G/A Amendment 2 VSTM · 92337C203	VSTM	92337C203	9.9%	7,836,346	13G/A Amendment 2	2/17/2026 Event 12/31/2025
RTW Investments, LP			9.9%	7,836,346
Roderick Wong			9.9%	7,836,346
uniQure N.V. 13G/A Amendment 3 QURE · N90064101	QURE	N90064101	6.0%	3,711,462	13G/A Amendment 3	2/17/2026 Event 12/31/2025
RTW Investments, LP			6.0%	3,711,462
Roderick Wong			6.0%	3,711,462
Tenax Therapeutics, Inc. 13G/A Amendment 1 TENX · 88032L605	TENX	88032L605	9.9%	650,968	13G/A Amendment 1	2/17/2026 Event 12/31/2025
RTW Investments, LP			9.9%	650,968
Roderick Wong			9.9%	650,968
Taysha Gene Therapies, Inc. 13G/A Amendment 4 TSHA · 877619106	TSHA	877619106	8.3%	23,407,133	13G/A Amendment 4	2/17/2026 Event 12/31/2025
RTW Investments, LP			8.3%	23,407,133
Roderick Wong			8.3%	23,407,133
SAB Biotherapeutics, Inc. 13G/A Amendment 2 SABS · 78397T202	SABS	78397T202	3.2%	1,587,302	13G/A Amendment 2	2/17/2026 Event 12/31/2025
RTW Investments, LP			3.2%	1,587,302
Roderick Wong			3.2%	1,587,302
Rapt Therapeutics, Inc. 13G/A Amendment 1 RAPT · 75382E208	RAPT	75382E208	5.9%	1,637,165	13G/A Amendment 1	2/17/2026 Event 12/31/2025
RTW Investments, LP			5.9%	1,637,165
Roderick Wong			5.9%	1,637,165
RadNet, Inc. 13G RDNT · 750491102	RDNT	750491102	5.1%	3,938,500	13G	2/17/2026 Event 12/31/2025
RTW Investments, LP			5.1%	3,938,500
Roderick Wong			5.1%	3,938,500
Protagonist Therapeutics, Inc 13G/A Amendment 6 PTGX · 74366E102	PTGX	74366E102	8.1%	5,059,053	13G/A Amendment 6	2/17/2026 Event 12/31/2025
RTW Investments, LP			8.1%	5,059,053
Roderick Wong			8.1%	5,059,053
Oruka Therapeutics, Inc. 13G/A Amendment 1 ORKA · 687604108	ORKA	687604108	4.3%	2,058,148	13G/A Amendment 1	2/17/2026 Event 12/31/2025
RTW Investments, LP			4.3%	2,058,148
Roderick Wong			4.3%	2,058,148
Kalaris Therapeutics, Inc. 13G KLRS · 482929106	KLRS	482929106	5.7%	1,300,000	13G	2/17/2026 Event 12/31/2025
RTW Investments, LP			5.7%	1,300,000
Roderick Wong			5.7%	1,300,000
Immatics N.V. 13G/A Amendment 3 IMTX · N44445109	IMTX	N44445109	8.5%	11,433,354	13G/A Amendment 3	2/17/2026 Event 12/31/2025
RTW Investments, LP			8.5%	11,433,354
Roderick Wong			8.5%	11,433,354
Exagen Inc. 13G/A Amendment 6 XGN · 30068X103	XGN	30068X103	4.9%	1,148,768	13G/A Amendment 6	2/17/2026 Event 12/31/2025
RTW Investments, LP			4.9%	1,148,768
Roderick Wong			4.9%	1,148,768
Castle Biosciences, Inc. 13G CSTL · 14843C105	CSTL	14843C105	7.2%	2,115,237	13G	2/17/2026 Event 12/31/2025
RTW Investments, LP			7.2%	2,115,237
Roderick Wong			7.2%	2,115,237
Beta Bionics, Inc. 13G/A Amendment 1 BBNX · 08659B102	BBNX	08659B102	5.7%	2,500,000	13G/A Amendment 1	2/17/2026 Event 12/31/2025
RTW Investments, LP			5.7%	2,500,000
Roderick Wong			5.7%	2,500,000
Apogee Therapeutics, Inc. 13G/A Amendment 1 APGE · 03770N101	APGE	03770N101	4.9%	2,712,097	13G/A Amendment 1	2/17/2026 Event 12/31/2025
RTW Investments, LP			4.9%	2,712,097
Roderick Wong			4.9%	2,712,097
Apellis Pharmaceuticals, Inc. 13G APLS · 03753U106	APLS	03753U106	6.1%	7,666,764	13G	2/17/2026 Event 12/31/2025
RTW Investments, LP			6.1%	7,666,764
Roderick Wong			6.1%	7,666,764
Alector, Inc. 13G/A Amendment 1 ALEC · 014442107	ALEC	014442107	0%	0	13G/A Amendment 1	2/17/2026 Event 12/31/2025
RTW Investments, LP			0%	0
Roderick Wong			0%	0
Akero Therapeutics, Inc. 13G/A Amendment 4 AKRO · 00973Y108	AKRO	00973Y108	0%	0	13G/A Amendment 4	2/17/2026 Event 12/31/2025
RTW Investments, LP			0%	0
Roderick Wong			0%	0
Zai Lab Limited 13G/A Amendment 1 ZLAB · 98887Q104	ZLAB	98887Q104	2.1%	22,913,720	13G/A Amendment 1	11/14/2025 Event 9/30/2025
RTW Investments, LP			2.1%	22,913,720
Roderick Wong			2.1%	22,913,720
Xencor Inc 13G XNCR · 98401F105	XNCR	98401F105	8.7%	6,221,054	13G	11/14/2025 Event 9/30/2025
RTW Investments, LP			8.7%	6,221,054
Roderick Wong			8.7%	6,221,054
uniQure N.V. 13G/A Amendment 2 QURE · N90064101	QURE	N90064101	7.2%	4,424,968	13G/A Amendment 2	11/14/2025 Event 9/30/2025
RTW Investments, LP			7.2%	4,424,968
Roderick Wong			7.2%	4,424,968
Replimune Group, Inc. 13G REPL · 76029N106	REPL	76029N106	8.2%	6,395,732	13G	11/14/2025 Event 9/30/2025
RTW Investments, LP			8.2%	6,395,732
Roderick Wong			8.2%	6,395,732
Milestone Pharmaceuticals Inc. 13G/A Amendment 6 MIST · 59935V107	MIST	59935V107	9.9%	9,155,168	13G/A Amendment 6	11/14/2025 Event 9/30/2025
RTW Investments, LP			9.9%	9,155,168
Roderick Wong			9.9%	9,155,168
Merus N.V. 13G/A Amendment 1 MRUS · N5749R100	MRUS	N5749R100	2.7%	2,025,277	13G/A Amendment 1	11/14/2025 Event 9/30/2025
RTW Investments, LP			2.7%	2,025,277
Roderick Wong			2.7%	2,025,277
Immatics N.V. 13G/A Amendment 2 IMTX · N44445109	IMTX	N44445109	7.3%	8,815,617	13G/A Amendment 2	11/14/2025 Event 9/30/2025
RTW Investments, LP			7.3%	8,815,617
Roderick Wong			7.3%	8,815,617
Cargo Therapeutics, Inc. 13G/A Amendment 3 CRGX · 14179K101	CRGX	14179K101	0%	0	13G/A Amendment 3	11/14/2025 Event 9/30/2025
RTW Investments, LP			0%	0
Roderick Wong			0%	0
Aquestive Therapeutics, Inc. 13G AQST · 03843E104	AQST	03843E104	5.2%	6,250,000	13G	11/14/2025 Event 9/30/2025
RTW Investments, LP			5.2%	6,250,000
Roderick Wong			5.2%	6,250,000
Alector, Inc. 13G ALEC · 014442107	ALEC	014442107	6.9%	6,990,806	13G	11/14/2025 Event 9/30/2025
RTW Investments, LP			6.9%	6,990,806
Roderick Wong			6.9%	6,990,806
Acadia Pharmaceuticals Inc. 13G/A Amendment 3 ACAD · 004225108	ACAD	004225108	4.2%	7,144,524	13G/A Amendment 3	11/14/2025 Event 9/30/2025
RTW Investments, LP			4.2%	7,144,524
Roderick Wong			4.2%	7,144,524
Allurion Technologies, Inc. 13D/A Amendment 10 ALUR · 02008G201	ALUR	02008G201	48.1%	5,891,430	13D/A Amendment 10	11/13/2025 Event 11/11/2025
RTW Investments, LP			48.1%	5,891,430
RTW Master Fund, Ltd.			25.5%	3,138,798
RTW Innovation Master Fund, Ltd.			19.8%	2,427,089
Roderick Wong			48.1%	5,891,430
Allurion Technologies, Inc. 13D/A Amendment 9 ALUR · 02008G201	ALUR	02008G201	43.6%	4,035,142	13D/A Amendment 9	11/7/2025 Event 11/5/2025
RTW Investments, LP			43.6%	4,035,142
RTW Master Fund, Ltd.			23.2%	2,147,254
RTW Innovation Master Fund, Ltd.			17.9%	1,659,241
Roderick Wong			43.6%	4,035,142
Avidity Biosciences, Inc. 13D/A Amendment 5 RNAM · 05370A108	RNAM	05370A108	3.1%	4,686,110	13D/A Amendment 5	10/29/2025 Event 10/27/2025
RTW Investments, LP			3.1%	4,686,110
Roderick Wong			3.1%	4,686,110
COMPASS Pathways plc 13G/A Amendment 1 CMPS · 20451W101	CMPS	20451W101	9.9%	9,474,397	13G/A Amendment 1	8/14/2025 Event 6/30/2025
RTW Investments, LP			9.9%	9,474,397
Roderick Wong			9.9%	9,474,397
Compass Therapeutics, Inc. 13G/A Amendment 1 CMPS · 20451W101	CMPS	20451W101	0%	0	13G/A Amendment 1	8/14/2025 Event 6/30/2025
RTW Investments, LP			0%	0
Roderick Wong			0%	0
Zai Lab Limited 13G ZLAB · 98887Q104	ZLAB	98887Q104	5.1%	55,368,760	13G	8/14/2025 Event 6/30/2025
RTW Investments, LP			5.1%	55,368,760
Roderick Wong			5.1%	55,368,760
Verastem, Inc. 13G/A Amendment 1 VSTM · 92337C203	VSTM	92337C203	9.9%	5,626,803	13G/A Amendment 1	8/14/2025 Event 6/30/2025
RTW Investments, LP			9.9%	5,626,803
Roderick Wong			9.9%	5,626,803
uniQure N.V. 13G/A Amendment 1 QURE · N90064101	QURE	N90064101	9.4%	5,158,231	13G/A Amendment 1	8/14/2025 Event 6/30/2025
RTW Investments, LP			9.4%	5,158,231
Roderick Wong			9.4%	5,158,231
Taysha Gene Therapies, Inc. 13G/A Amendment 3 TSHA · 877619106	TSHA	877619106	9.9%	25,183,287	13G/A Amendment 3	8/14/2025 Event 6/30/2025
RTW Investments, LP			9.9%	25,183,287
Roderick Wong			9.9%	25,183,287
Tarsus Pharmaceuticals, Inc. 13G/A Amendment 5 TARS · 87650L103	TARS	87650L103	8.1%	3,424,180	13G/A Amendment 5	8/14/2025 Event 6/30/2025
RTW Investments, LP			8.1%	3,424,180
Roderick Wong			8.1%	3,424,180
Exagen Inc. 13G/A Amendment 5 XGN · 30068X103	XGN	30068X103	7.7%	1,696,866	13G/A Amendment 5	8/14/2025 Event 6/30/2025
RTW Investments, LP			7.7%	1,696,866
Roderick Wong			7.7%	1,696,866
Compass Therapeutics, Inc. 13G/A Amendment 1 CMPS · 20451W101	CMPS	20451W101	9.9%	9,474,397	13G/A Amendment 1	8/14/2025 Event 6/30/2025
RTW Investments, LP			9.9%	9,474,397
Roderick Wong			9.9%	9,474,397
Cargo Therapeutics, Inc. 13G/A Amendment 2 CRGX · 14179K101	CRGX	14179K101	6.4%	3,055,063	13G/A Amendment 2	8/14/2025 Event 6/30/2025
RTW Investments, LP			6.4%	3,055,063
Roderick Wong			6.4%	3,055,063
Axsome Therapeutics, Inc. 13G/A Amendment 4 AXSM · 05464T104	AXSM	05464T104	3.1%	1,516,903	13G/A Amendment 4	8/14/2025 Event 6/30/2025
RTW Investments, LP			3.1%	1,516,903
Roderick Wong			3.1%	1,516,903
Akero Therapeutics, Inc. 13G/A Amendment 3 AKRO · 00973Y108	AKRO	00973Y108	7.3%	5,873,308	13G/A Amendment 3	8/14/2025 Event 6/30/2025
RTW Investments, LP			7.3%	5,873,308
Roderick Wong			7.3%	5,873,308
Orchestra Biomed Holdings, Inc. 13D/A Amendment 5 OBIO · 68572M106	OBIO	68572M106	15.4%	8,306,063	13D/A Amendment 5	8/6/2025 Event 8/4/2025
RTW Investments, LP			15.4%	8,306,063
RTW Master Fund, Ltd.			8.1%	4,394,985
RTW Innovation Master Fund, Ltd.			5.7%	3,053,082
Roderick Wong			15.4%	8,306,063
Tenax Therapeutics, Inc. 13G TENX · 88032L605	TENX	88032L605	10.0%	418,440	13G	5/15/2025 Event 3/31/2025
RTW Investments, LP			10.0%	418,440
Roderick Wong, M.D.			10.0%	418,440
89bio, Inc. 13G/A Amendment 2 ETNB · 282559103	ETNB	282559103	1.3%	1,967,527	13G/A Amendment 2	5/15/2025 Event 3/31/2025
RTW Investments, LP			1.3%	1,967,527
Roderick Wong, M.D.			1.3%	1,967,527
GH Research PLC 13G/A Amendment 1 GHRS · G3855L106	GHRS	G3855L106	8.9%	5,499,769	13G/A Amendment 1	5/15/2025 Event 3/31/2025
RTW Investments, LP			8.9%	5,499,769
Roderick Wong, M.D.			8.9%	5,499,769
PepGen Inc. 13G/A Amendment 1 PEPG · 713317105	PEPG	713317105	0%	0	13G/A Amendment 1	5/15/2025 Event 3/31/2025
RTW Investments, LP			0%	0
Roderick Wong, M.D.			0%	0
Dyne Therapeutics, Inc. 13G/A Amendment 2 DYN · 26818M108	DYN	26818M108	1.5%	1,690,567	13G/A Amendment 2	5/15/2025 Event 3/31/2025
RTW Investments, LP			1.5%	1,690,567
Roderick Wong, M.D.			1.5%	1,690,567
Beta Bionics, Inc. 13G BBNX · 08659B102	BBNX	08659B102	7.6%	3,299,869	13G	5/15/2025 Event 3/31/2025
RTW Investments, LP			7.6%	3,299,869
Roderick Wong, M.D.			7.6%	3,299,869
Axsome Therapeutics, Inc. 13G/A Amendment 3 AXSM · 05464T104	AXSM	05464T104	6.0%	2,922,729	13G/A Amendment 3	5/15/2025 Event 3/31/2025
RTW Investments, LP			6.0%	2,922,729
Roderick Wong, M.D.			6.0%	2,922,729
Verastem, Inc. 13G VSTM · 92337C203	VSTM	92337C203	8.3%	4,245,476	13G	5/15/2025 Event 3/31/2025
RTW Investments, LP			8.3%	4,245,476
Roderick Wong, M.D.			8.3%	4,245,476
Immunic, Inc. 13G/A Amendment 4 IMUX · 4525EP101	IMUX	4525EP101	1.1%	1,026,762	13G/A Amendment 4	5/15/2025 Event 3/31/2025
RTW Investments, LP			1.1%	1,026,762
Roderick Wong, M.D.			1.1%	1,026,762
Taysha Gene Therapies, Inc. 13G/A Amendment 2 TSHA · 877619106	TSHA	877619106	10.0%	20,673,307	13G/A Amendment 2	5/15/2025 Event 3/31/2025
RTW Investments, LP			10.0%	20,673,307
Roderick Wong, M.D.			10.0%	20,673,307
Oruka Therapeutics, Inc. 13G ORKA · 687604108	ORKA	687604108	5.2%	1,945,649	13G	5/15/2025 Event 3/31/2025
RTW Investments, LP			5.2%	1,945,649
Roderick Wong, M.D.			5.2%	1,945,649
Rapt Therapeutics, Inc. 13G RAPT · 75382E109	RAPT	75382E109	8.9%	11,764,000	13G	5/15/2025 Event 3/31/2025
RTW Investments, LP			8.9%	11,764,000
Roderick Wong, M.D.			8.9%	11,764,000
uniQure N.V. 13G QURE · N90064101	QURE	N90064101	7.9%	4,265,428	13G	5/15/2025 Event 3/31/2025
RTW Investments, LP			7.9%	4,265,428
Roderick Wong, M.D.			7.9%	4,265,428
COMPASS Pathways plc 13G CMPS · 20451W101	CMPS	20451W101	8.3%	7,877,349	13G	5/15/2025 Event 3/31/2025
RTW Investments, LP			8.3%	7,877,349
Roderick Wong, M.D.			8.3%	7,877,349
Orchestra Biomed Holdings, Inc. 13D/A Amendment 4 OBIO · 68572M106	OBIO	68572M106	21.7%	8,306,063	13D/A Amendment 4	5/1/2025 Event 4/29/2025
RTW Investments, LP			21.7%	8,306,063
RTW Master Fund, Ltd.			11.5%	4,394,985
RTW Innovation Master Fund, Ltd.			8.0%	3,053,082
Roderick Wong, M.D.			21.7%	8,306,063
Allurion Technologies, Inc. 13D/A Amendment 8 ALUR · 02008G201	ALUR	02008G201	34.1%	2,542,603	13D/A Amendment 8	4/17/2025 Event 4/15/2025
RTW Investments, LP			34.1%	2,542,603
RTW Master Fund, Ltd.			17.8%	1,324,532
RTW Innovation Master Fund, Ltd.			13.8%	1,027,287
Roderick Wong, M.D.			34.1%	2,542,603
Allurion Technologies, Inc. 13D/A Amendment 7 ALUR · 02008G102	ALUR	02008G102	17.6%	1,050,053	13D/A Amendment 7	2/24/2025 Event 2/20/2025
RTW Investments, LP			17.6%	1,050,053
RTW Master Fund, Ltd.			8.4%	501,806
RTW Innovation Master Fund, Ltd.			6.6%	395,328
Roderick Wong, M.D.			17.6%	1,050,053
Stoke Therapeutics, Inc. 13G/A Amendment 6 STOK · 86150R107	STOK	86150R107	10.0%	5,310,033	13G/A Amendment 6	2/14/2025 Event 12/31/2024
RTW Investments, LP			10.0%	5,310,033
Roderick Wong, M.D.			10.0%	5,310,033
Akero Therapeutics, Inc. 13G/A Amendment 2 AKRO · 00973Y108	AKRO	00973Y108	9.8%	6,859,823	13G/A Amendment 2	2/14/2025 Event 12/31/2024
RTW Investments, LP			9.8%	6,859,823
Roderick Wong, M.D.			9.8%	6,859,823
Acadia Pharmaceuticals Inc. 13G/A Amendment 2 ACAD · 004225108	ACAD	004225108	5.2%	8,705,501	13G/A Amendment 2	2/14/2025 Event 12/31/2024
RTW Investments, LP			5.2%	8,705,501
Roderick Wong, M.D.			5.2%	8,705,501