Investors who own more than 5% of a class must file a Schedule 13D or 13G. Each filer's latest filing for 4525EP101 since 12/18/2024, largest first.
| Filer | % of Class | Filed | ||
|---|---|---|---|---|
|
Vivo Opportunity Fund Holdings, L.P.
13G
|
10.0% |
2/20/2026
Event 2/17/2026
|
||
| Vivo Opportunity Fund Holdings, L.P. | 10.0% | |||
| Vivo Opportunity, LLC | 10.0% | |||
| Vivo Opportunity Cayman Fund, L.P. | 10.0% | |||
| Vivo Opportunity Cayman, LLC | 10.0% | |||
|
Biotechnology Value Fund L P
13D
|
10.0% |
2/20/2026
Event 2/12/2026
|
||
| Biotechnology Value Fund L P | 7.4% | |||
| BVF I GP LLC | 7.4% | |||
| Biotechnology Value Fund II LP | 2.2% | |||
| BVF II GP LLC | 2.2% | |||
| Biotechnology Value Trading Fund OS LP | 0.3% | |||
| BVF Partners OS Ltd. | 0.3% | |||
| BVF GP Holdings LLC | 9.6% | |||
| BVF Partners L P/IL | 10.0% | |||
| BVF Inc/IL | 10.0% | |||
| Lampert Mark N | 10.0% | |||
| R. Thorvald Nagel | 0% | |||
| Janus Henderson Group PLC 13G | 10.0% |
12/8/2025
Event 11/28/2025
|
||
|
Adage Capital Management, L.P.
13G/A
|
10.0% |
8/12/2025
Event 6/30/2025
|
||
| Adage Capital Management, L.P. | 10.0% | |||
| Robert Atchinson | 10.0% | |||
| Phillip Gross | 10.0% | |||
|
Avidity Partners Management LP
13G
|
9.9% |
4/17/2026
Event 2/17/2026
|
||
| Avidity Partners Management LP | 9.9% | |||
| Avidity Partners Management (GP) LLC | 9.9% | |||
| Avidity Capital Partners Fund (GP) LP | 9.9% | |||
| Avidity Capital Partners (GP) LLC | 9.9% | |||
| Avidity Private Master Fund I LP | 9.9% | |||
| Michael Gregory | 9.9% | |||
|
Trails Edge Capital Partners, LP
13G
|
8.7% |
2/24/2026
Event 2/17/2026
|
||
| Trails Edge Capital Partners, LP | 8.7% | |||
| Trails Edge Biotechnology Master Fund, LP | 8.7% | |||
| Ortav Yehudai | 8.7% | |||
|
Deep Track Capital, LP
13G
|
8.7% |
3/4/2026
Event 2/17/2026
|
||
| Deep Track Capital, LP | 8.7% | |||
| Deep Track Biotechnology Master Fund, Ltd. | 6.8% | |||
| David Kroin | 8.7% | |||
| Deep Track Special Opportunities Fund, LP. | 1.9% | |||
|
Nantahala Capital Management, LLC
13G/A
|
8.2% |
2/13/2026
Event 12/31/2025
|
||
| Nantahala Capital Management, LLC | 8.2% | |||
| Wilmot B. Harkey | 8.2% | |||
| Daniel Mack | 8.2% | |||
|
Aberdeen Group plc
13G/A
|
6.9% |
2/2/2026
Event 12/31/2025
|
||
| Aberdeen Group plc | 6.9% | |||
| abrdn Inc. | 6.9% | |||
|
683 Capital Management, LLC
13G/A
|
5.9% |
2/17/2026
Event 12/31/2025
|
||
| 683 Capital Management, LLC | 5.9% | |||
| 683 Capital Partners, LP | 5.9% | |||
| Zweiman Ari | 5.9% | |||
|
Soleus Capital Master Fund, L.P.
13G
|
5.5% |
2/19/2026
Event 2/17/2026
|
||
| Soleus Capital Master Fund, L.P. | 5.5% | |||
| Soleus Capital, LLC | 5.5% | |||
| Soleus Capital Group, LLC | 5.5% | |||
| Soleus Capital Management, L.P. | 5.5% | |||
| Soleus GP, LLC | 5.5% | |||
| Guy Levy | 5.5% | |||
|
OrbiMed Advisors LLC
13G
|
5.3% |
8/14/2026
Event 6/30/2026
|
||
| OrbiMed Advisors LLC | 5.3% | |||
| OrbiMed Genesis GP LLC | 5.3% | |||
| OrbiMed Capital LLC | 2.8% | |||
| Under 5%, checked the "5 percent or less" box, or amended by a later filing (6) | ||||
|
Commodore Capital LP
13G
|
9.9% |
2/24/2026
Event 2/17/2026
|
||
| Commodore Capital LP | 9.9% | |||
| Commodore Capital Master LP | 9.9% | |||
| Robert Egen Atkinson | 9.9% | |||
| Michael Kramarz | 9.9% | |||
|
Armistice Capital, LLC
13G/A
|
4.99% |
11/14/2025
Event 9/30/2025
|
||
| Armistice Capital, LLC | 4.99% | |||
| Steven Boyd | 4.99% | |||
|
Alyeska Investment Group, L.P.
13G/A
|
4.9% |
5/15/2026
Event 3/31/2026
|
||
| Alyeska Investment Group, L.P. | 4.9% | |||
| Alyeska Fund GP, LLC | 4.9% | |||
| Anand Parekh | 4.9% | |||
| Vanguard Group Inc 13G/A | 4.4% |
1/30/2025
Event 12/31/2024
|
||
|
Soleus Private Equity Fund III, L.P.
13G/A
|
1.6% |
11/7/2025
Event 9/30/2025
|
||
| Soleus Private Equity Fund III, L.P. | 1.1% | |||
| Soleus Private Equity GP III, LLC | 1.1% | |||
| Soleus PE GP III, LLC | 1.1% | |||
| Soleus Capital Master Fund, L.P. | 0.5% | |||
| Soleus Capital, LLC | 0.5% | |||
| Soleus Capital Group, LLC | 0.5% | |||
| Soleus Capital Management, L.P. | 1.6% | |||
| Soleus GP, LLC | 1.6% | |||
| Guy Levy | 1.6% | |||
|
RTW Investments, LP
13G/A
|
1.1% |
5/15/2025
Event 3/31/2025
|
||
| RTW Investments, LP | 1.1% | |||
| Roderick Wong, M.D. | 1.1% | |||
| Period | Filings | Shares, Excl. Options | Value, Excl. Options |
|---|---|---|---|
| 2026 Q1 | 82 | 64.7 M | $77.4 M |
| 2025 Q4 | 64 | 51.3 M | $28.3 M |
| 2025 Q3 | 66 | 42.7 M | $37.7 M |
| 2025 Q2 | 60 | 50.2 M | $35.0 M |
| 2025 Q1 | 72 | 40.5 M | $44.1 M |
| 2024 Q4 | 74 | 53.3 M | $53.3 M |
| 2024 Q3 | 68 | 56.0 M | $92.4 M |
| 2024 Q2 | 63 | 55.9 M | $62.1 M |
| 2024 Q1 | 68 | 57.4 M | $75.8 M |
| 2023 Q4 | 57 | 15.2 M | $22.7 M |
| 2023 Q3 | 58 | 18.4 M | $27.0 M |
| 2023 Q2 | 71 | 20.2 M | $50.7 M |
| 2023 Q1 | 67 | 25.3 M | $37.7 M |
| 2022 Q4 | 72 | 24.9 M | $34.9 M |
| 2022 Q3 | 80 | 18.5 M | $58.3 M |
| 2022 Q2 | 89 | 18.3 M | $63.4 M |
| 2022 Q1 | 100 | 17.6 M | $199 M |
| 2021 Q4 | 76 | 13.7 M | $131 M |
| 2021 Q3 | 74 | 12.9 M | $114 M |
| 2021 Q2 | 69 | 9.44 M | $116 M |
| 2021 Q1 | 70 | 9.30 M | $148 M |
| 2020 Q4 | 79 | 9.76 M | $149 M |
| 2020 Q3 | 73 | 8.55 M | $159 M |
| 2020 Q2 | 55 | 4.24 M | $51.5 M |
| 2020 Q1 | 27 | 2.16 M | $13.0 M |
| 2019 Q4 | 25 | 2.14 M | $20.7 M |
| 2019 Q3 | 28 | 1.50 M | $15.0 M |
| 2019 Q2 | 27 | 1.54 M | $17.6 M |