BIOTECHNOLOGY VALUE FUND L P

13D and 13G Filings

13D/G filings: 13D on 9 securities, 13G on 55 securities
Location: San Francisco, CA
CIK: 0000918923
Form D filings: 16 filings
All SEC filings: View on sec.gov

Issuer	Symbol	CUSIP	% of Class	Shares	Form	Filed
Schedule 13D · 9 securities · may seek to influence control
Olema Pharmaceuticals, Inc. 13D/A OLMA · 68062P106	OLMA	68062P106	9.8%	8,939,731	13D/A	10/16/2026 Event 10/14/2026
Biotechnology Value Fund L P			6.6%	5,946,981
BVF I GP LLC			6.6%	5,946,981
Biotechnology Value Fund II LP			2.7%	2,356,800
BVF II GP LLC			2.7%	2,356,800
Biotechnology Value Trading Fund OS LP			0.4%	347,970
BVF Partners OS Ltd.			0.4%	347,970
BVF GP Holdings LLC			9.1%	8,303,781
BVF Partners L P/IL			9.8%	8,939,731
BVF Inc/IL			9.8%	8,939,731
Lampert Mark N			9.8%	8,939,731
Hrustanovic Gorjan			0.2%	183,645
Entera Bio Ltd. 13D ENTX · M40527109	ENTX	M40527109	10.0%	17,225,121	13D	8/4/2026 Event 7/28/2026
Biotechnology Value Fund L P			5.3%	9,171,741
BVF I GP LLC			5.3%	9,171,741
Biotechnology Value Fund II LP			3.9%	6,685,480
BVF II GP LLC			3.9%	6,685,480
Biotechnology Value Trading Fund OS LP			0.7%	1,124,329
BVF Partners OS Ltd.			0.7%	1,124,329
BVF GP Holdings LLC			9.2%	15,857,221
BVF Partners L P/IL			10.0%	17,225,121
BVF Inc/IL			10.0%	17,225,121
Lampert Mark N			10.0%	17,225,121
XOMA Royalty Corp 13D/A XOMA · 98419J206	XOMA	98419J206	0%	0	13D/A	7/16/2026 Event 7/14/2026
Biotechnology Value Fund L P			0%	0
BVF I GP LLC			0%	0
Biotechnology Value Fund II LP			0%	0
BVF II GP LLC			0%	0
Biotechnology Value Trading Fund OS LP			0%	0
BVF Partners OS Ltd.			0%	0
BVF GP Holdings LLC			0%	0
BVF Partners L P/IL			0%	0
BVF Inc/IL			0%	0
Lampert Mark N			0%	0
MoonLake Immunotherapeutics 13D/A MLTX · 61559X104	MLTX	61559X104	19.7%	16,001,284	13D/A	6/29/2026 Event 6/25/2026
Biotechnology Value Fund L P			10.2%	8,302,735
BVF I GP LLC			10.2%	8,302,735
Biotechnology Value Fund II LP			8.1%	6,599,722
BVF II GP LLC			8.1%	6,599,722
Biotechnology Value Trading Fund OS LP			1.3%	1,039,238
BVF Partners OS Ltd.			1.3%	1,039,238
BVF GP Holdings LLC			18.4%	14,902,457
BVF Partners L P/IL			19.7%	16,001,284
BVF Inc/IL			19.7%	16,001,284
Lampert Mark N			19.7%	16,001,284
Loy Spike			<0.1%	25,667
Kymera Therapeutics, Inc. 13D/A KYMR · 501575104	KYMR	501575104	6.3%	5,237,151	13D/A	6/26/2026 Event 6/26/2026
Biotechnology Value Fund L P			3.3%	2,712,852
BVF I GP LLC			3.3%	2,712,852
Biotechnology Value Fund II LP			2.6%	2,124,859
BVF II GP LLC			2.6%	2,124,859
Biotechnology Value Trading Fund OS LP			0.4%	292,856
BVF Partners OS Ltd.			0.4%	292,856
BVF GP Holdings LLC			5.8%	4,837,711
BVF Partners L P/IL			6.3%	5,237,151
BVF Inc/IL			6.3%	5,237,151
Lampert Mark N			6.3%	5,237,151
Hrustanovic Gorjan			0.1%	116,190
Immunic, Inc. 13D IMUX · 4525EP101	IMUX	4525EP101	10.0%	13,630,601	13D	2/20/2026 Event 2/12/2026
Biotechnology Value Fund L P			7.4%	10,113,585
BVF I GP LLC			7.4%	10,113,585
Biotechnology Value Fund II LP			2.2%	3,027,105
BVF II GP LLC			2.2%	3,027,105
Biotechnology Value Trading Fund OS LP			0.3%	427,629
BVF Partners OS Ltd.			0.3%	427,629
BVF GP Holdings LLC			9.6%	13,140,690
BVF Partners L P/IL			10.0%	13,630,601
BVF Inc/IL			10.0%	13,630,601
Lampert Mark N			10.0%	13,630,601
R. Thorvald Nagel			0%	0
Repare Therapeutics Inc. 13D/A RPTX · 760273102	RPTX	760273102	0%	0	13D/A	1/30/2026 Event 1/28/2026
Biotechnology Value Fund L P			0%	0
BVF I GP LLC			0%	0
Biotechnology Value Fund II LP			0%	0
BVF II GP LLC			0%	0
Biotechnology Value Trading Fund OS LP			0%	0
BVF Partners OS Ltd.			0%	0
BVF GP Holdings LLC			0%	0
BVF Partners L P/IL			0%	0
BVF Inc/IL			0%	0
Lampert Mark N			0%	0
Inventiva S.A. 13D/A IVA · 46124U107	IVA	46124U107	4.99%	9,569,863	13D/A	11/19/2025 Event 11/17/2025
Biotechnology Value Fund L P			2.9%	5,654,825
BVF I GP LLC			2.9%	5,654,825
Biotechnology Value Fund II LP			1.7%	3,321,861
BVF II GP LLC			1.7%	3,321,861
Biotechnology Value Trading Fund OS LP			0.2%	397,086
BVF Partners OS Ltd.			0.2%	397,086
BVF GP Holdings LLC			4.7%	8,976,686
BVF Partners L P/IL			4.99%	9,569,863
BVF Inc/IL			4.99%	9,569,863
Lampert Mark N			4.99%	9,569,863
ESSA Pharma Inc. 13D/A EPIX · 29668H708	EPIX	29668H708	0%	0	13D/A	10/14/2025 Event 10/9/2025
Biotechnology Value Fund L P			0%	0
BVF I GP LLC			0%	0
Biotechnology Value Fund II LP			0%	0
BVF II GP LLC			0%	0
Biotechnology Value Trading Fund OS LP			0%	0
BVF Partners OS Ltd.			0%	0
BVF GP Holdings LLC			0%	0
BVF Partners L P/IL			0%	0
BVF Inc/IL			0%	0
Lampert Mark N			0%	0
Schedule 13G · 55 securities · passive
Frazier Life Sciences Acquisition Corp. II 13G G37103101		G37103101	6.4%	500,000	13G	10/21/2026 Event 10/14/2026
Biotechnology Value Fund L P			3.3%	260,192
BVF I GP LLC			3.3%	260,192
Biotechnology Value Fund II LP			2.4%	190,983
BVF II GP LLC			2.4%	190,983
Biotechnology Value Trading Fund OS LP			0.5%	37,568
BVF Partners OS Ltd.			0.5%	37,568
BVF GP Holdings LLC			5.8%	451,175
BVF Partners L P/IL			6.4%	500,000
BVF Inc/IL			6.4%	500,000
Lampert Mark N			6.4%	500,000
Foghorn Therapeutics Inc. 13G/A FHTX · 344174107	FHTX	344174107	14.3%	8,507,000	13G/A	10/5/2026 Event 10/1/2026
Biotechnology Value Fund L P			7.6%	4,494,462
BVF I GP LLC			7.6%	4,494,462
Biotechnology Value Fund II LP			5.4%	3,232,448
BVF II GP LLC			5.4%	3,232,448
Biotechnology Value Trading Fund OS LP			1.0%	619,258
BVF Partners OS Ltd.			1.0%	619,258
BVF GP Holdings LLC			13.0%	7,726,910
BVF Partners L P/IL			14.3%	8,507,000
BVF Inc/IL			14.3%	8,507,000
Lampert Mark N			14.3%	8,507,000
Stoke Therapeutics, Inc. 13G STOK · 86150R107	STOK	86150R107	5.6%	3,608,968	13G	9/30/2026 Event 9/23/2026
Biotechnology Value Fund L P			2.9%	1,866,761
BVF I GP LLC			2.9%	1,866,761
Biotechnology Value Fund II LP			2.2%	1,404,263
BVF II GP LLC			2.2%	1,404,263
Biotechnology Value Trading Fund OS LP			0.4%	261,006
BVF Partners OS Ltd.			0.4%	261,006
BVF GP Holdings LLC			5.1%	3,271,024
BVF Partners L P/IL			5.6%	3,608,968
BVF Inc/IL			5.6%	3,608,968
Lampert Mark N			5.6%	3,608,968
Tyra Biosciences, Inc. 13G TYRA · 90240B106	TYRA	90240B106	6.1%	4,215,886	13G	9/21/2026 Event 9/14/2026
Biotechnology Value Fund L P			3.2%	2,203,710
BVF I GP LLC			3.2%	2,203,710
Biotechnology Value Fund II LP			2.4%	1,651,007
BVF II GP LLC			2.4%	1,651,007
Biotechnology Value Trading Fund OS LP			0.4%	278,491
BVF Partners OS Ltd.			0.4%	278,491
BVF GP Holdings LLC			5.6%	3,854,717
BVF Partners L P/IL			6.1%	4,215,886
BVF Inc/IL			6.1%	4,215,886
Lampert Mark N			6.1%	4,215,886
Alector, Inc. 13G ALEC · 014442107	ALEC	014442107	8.4%	9,374,267	13G	9/18/2026 Event 9/11/2026
Biotechnology Value Fund L P			4.4%	4,900,143
BVF I GP LLC			4.4%	4,900,143
Biotechnology Value Fund II LP			3.3%	3,671,016
BVF II GP LLC			3.3%	3,671,016
Biotechnology Value Trading Fund OS LP			0.6%	619,317
BVF Partners OS Ltd.			0.6%	619,317
BVF GP Holdings LLC			7.7%	8,571,159
BVF Partners L P/IL			8.4%	9,374,267
BVF Inc/IL			8.4%	9,374,267
Lampert Mark N			8.4%	9,374,267
Tenax Therapeutics, Inc. 13G/A TENX · 88032L605	TENX	88032L605	10.0%	3,110,363	13G/A	8/14/2026 Event 6/30/2026
Biotechnology Value Fund L P			9.5%	2,966,661
BVF I GP LLC			9.5%	2,966,661
Biotechnology Value Fund II LP			0.5%	141,570
BVF II GP LLC			0.5%	141,570
Biotechnology Value Trading Fund OS LP			0%	7
BVF Partners OS Ltd.			0%	7
BVF GP Holdings LLC			10.0%	3,108,231
BVF Partners L P/IL			10.0%	3,110,363
BVF Inc/IL			10.0%	3,110,363
Lampert Mark N			10.0%	3,110,363
TScan Therapeutics, Inc. 13G/A TCRX · 89854M101	TCRX	89854M101	10.0%	6,417,831	13G/A	8/14/2026 Event 6/30/2026
Biotechnology Value Fund L P			5.7%	3,649,002
BVF I GP LLC			5.7%	3,649,002
Biotechnology Value Fund II LP			4.2%	2,662,237
BVF II GP LLC			4.2%	2,662,237
Biotechnology Value Trading Fund OS LP			0.1%	83,135
BVF Partners OS Ltd.			0.1%	83,135
BVF GP Holdings LLC			9.8%	6,311,239
BVF Partners L P/IL			10.0%	6,417,831
BVF Inc/IL			10.0%	6,417,831
Lampert Mark N			10.0%	6,417,831
Palvella Therapeutics, Inc. 13G/A PVLA · 697947109	PVLA	697947109	4.7%	672,789	13G/A	8/14/2026 Event 6/30/2026
Biotechnology Value Fund L P			2.5%	352,699
BVF I GP LLC			2.5%	352,699
Biotechnology Value Fund II LP			1.9%	265,660
BVF II GP LLC			1.9%	265,660
Biotechnology Value Trading Fund OS LP			0.3%	44,510
BVF Partners OS Ltd.			0.3%	44,510
BVF GP Holdings LLC			4.3%	618,359
BVF Partners L P/IL			4.7%	672,789
BVF Inc/IL			4.7%	672,789
Lampert Mark N			4.7%	672,789
OnKure Therapeutics, Inc. 13G/A OKUR · 68277Q105	OKUR	68277Q105	8.0%	3,235,778	13G/A	8/14/2026 Event 6/30/2026
Biotechnology Value Fund L P			4.1%	1,671,617
BVF I GP LLC			4.1%	1,671,617
Biotechnology Value Fund II LP			3.2%	1,289,385
BVF II GP LLC			3.2%	1,289,385
Biotechnology Value Trading Fund OS LP			0.6%	226,497
BVF Partners OS Ltd.			0.6%	226,497
BVF GP Holdings LLC			7.3%	2,961,002
BVF Partners L P/IL			8.0%	3,235,778
BVF Inc/IL			8.0%	3,235,778
Lampert Mark N			8.0%	3,235,778
Nektar Therapeutics 13G/A NKTR · 640268306	NKTR	640268306	7.1%	2,391,075	13G/A	8/14/2026 Event 6/30/2026
Biotechnology Value Fund L P			3.7%	1,251,654
BVF I GP LLC			3.7%	1,251,654
Biotechnology Value Fund II LP			2.8%	945,732
BVF II GP LLC			2.8%	945,732
Biotechnology Value Trading Fund OS LP			0.5%	157,488
BVF Partners OS Ltd.			0.5%	157,488
BVF GP Holdings LLC			6.5%	2,197,386
BVF Partners L P/IL			7.1%	2,391,075
BVF Inc/IL			7.1%	2,391,075
Lampert Mark N			7.1%	2,391,075
Invivyd, Inc. 13G/A IVVD · 00534A102	IVVD	00534A102	10.0%	29,571,826	13G/A	8/14/2026 Event 6/30/2026
Biotechnology Value Fund L P			5.4%	16,031,969
BVF I GP LLC			5.4%	16,031,969
Biotechnology Value Fund II LP			3.8%	11,183,991
BVF II GP LLC			3.8%	11,183,991
Biotechnology Value Trading Fund OS LP			0.6%	1,887,918
BVF Partners OS Ltd.			0.6%	1,887,918
BVF GP Holdings LLC			9.2%	27,215,960
BVF Partners L P/IL			10.0%	29,571,826
BVF Inc/IL			10.0%	29,571,826
Lampert Mark N			10.0%	29,571,826
ImageneBio, Inc. 13G/A IMA · 45175G207	IMA	45175G207	9.9%	1,128,647	13G/A	8/14/2026 Event 6/30/2026
Biotechnology Value Fund L P			5.4%	611,834
BVF I GP LLC			5.4%	611,834
Biotechnology Value Fund II LP			3.8%	433,269
BVF II GP LLC			3.8%	433,269
Biotechnology Value Trading Fund OS LP			0.6%	66,808
BVF Partners OS Ltd.			0.6%	66,808
BVF GP Holdings LLC			9.3%	1,045,103
BVF Partners L P/IL			9.9%	1,128,647
BVF Inc/IL			9.9%	1,128,647
Lampert Mark N			9.9%	1,128,647
Cullinan Therapeutics, Inc. 13G/A CGEM · 230031106	CGEM	230031106	10.0%	6,491,123	13G/A	8/14/2026 Event 6/30/2026
Biotechnology Value Fund L P			5.7%	3,711,284
BVF I GP LLC			5.7%	3,711,284
Biotechnology Value Fund II LP			3.5%	2,269,166
BVF II GP LLC			3.5%	2,269,166
Biotechnology Value Trading Fund OS LP			0.6%	400,861
BVF Partners OS Ltd.			0.6%	400,861
BVF GP Holdings LLC			9.2%	5,980,450
BVF Partners L P/IL			10.0%	6,491,123
BVF Inc/IL			10.0%	6,491,123
Lampert Mark N			10.0%	6,491,123
Avalo Therapeutics, Inc. 13G/A AVTX · 05338F306	AVTX	05338F306	5.3%	2,801,545	13G/A	8/14/2026 Event 6/30/2026
Biotechnology Value Fund L P			2.8%	1,466,153
BVF I GP LLC			2.8%	1,466,153
Biotechnology Value Fund II LP			2.1%	1,107,854
BVF II GP LLC			2.1%	1,107,854
Biotechnology Value Trading Fund OS LP			0.4%	185,010
BVF Partners OS Ltd.			0.4%	185,010
BVF GP Holdings LLC			4.8%	2,574,007
BVF Partners L P/IL			5.3%	2,801,545
BVF Inc/IL			5.3%	2,801,545
Lampert Mark N			5.3%	2,801,545
TCGX Acquisition Corp. 13G TCGX · G8708J109	TCGX	G8708J109	5.5%	500,000	13G	8/12/2026 Event 8/5/2026
Biotechnology Value Fund L P			2.9%	261,310
BVF I GP LLC			2.9%	261,310
Biotechnology Value Fund II LP			2.1%	195,846
BVF II GP LLC			2.1%	195,846
Biotechnology Value Trading Fund OS LP			0.4%	33,068
BVF Partners OS Ltd.			0.4%	33,068
BVF GP Holdings LLC			5.0%	457,156
BVF Partners L P/IL			5.5%	500,000
BVF Inc/IL			5.5%	500,000
Lampert Mark N			5.5%	500,000
Research Alliance Corp IV 13G RACD · G75228109	RACD	G75228109	6.4%	500,000	13G	7/20/2026 Event 7/13/2026
Biotechnology Value Fund L P			3.4%	262,376
BVF I GP LLC			3.4%	262,376
Biotechnology Value Fund II LP			2.5%	196,800
BVF II GP LLC			2.5%	196,800
Biotechnology Value Trading Fund OS LP			0.4%	32,968
BVF Partners OS Ltd.			0.4%	32,968
BVF GP Holdings LLC			5.9%	459,176
BVF Partners L P/IL			6.4%	500,000
BVF Inc/IL			6.4%	500,000
Lampert Mark N			6.4%	500,000
Pyxis Oncology, Inc. 13G PYXS · 747324101	PYXS	747324101	10.0%	8,336,902	13G	7/10/2026 Event 7/2/2026
Biotechnology Value Fund L P			5.5%	4,611,887
BVF I GP LLC			5.5%	4,611,887
Biotechnology Value Fund II LP			3.7%	3,083,847
BVF II GP LLC			3.7%	3,083,847
Biotechnology Value Trading Fund OS LP			0.6%	518,280
BVF Partners OS Ltd.			0.6%	518,280
BVF GP Holdings LLC			9.2%	7,695,734
BVF Partners L P/IL			10.0%	8,336,902
BVF Inc/IL			10.0%	8,336,902
Lampert Mark N			10.0%	8,336,902
Q32 Bio Inc. 13G QTTB · 746964105	QTTB	746964105	10.0%	2,367,524	13G	6/4/2026 Event 5/28/2026
Biotechnology Value Fund L P			5.3%	1,248,973
BVF I GP LLC			5.3%	1,248,973
Biotechnology Value Fund II LP			3.9%	929,003
BVF II GP LLC			3.9%	929,003
Biotechnology Value Trading Fund OS LP			0.7%	155,156
BVF Partners OS Ltd.			0.7%	155,156
BVF GP Holdings LLC			9.2%	2,177,976
BVF Partners L P/IL			10.0%	2,367,524
BVF Inc/IL			10.0%	2,367,524
Lampert Mark N			10.0%	2,367,524
Research Alliance Corp III 13G RACC · G75226103	RACC	G75226103	6.4%	500,000	13G	5/29/2026 Event 5/21/2026
Biotechnology Value Fund L P			3.4%	261,923
BVF I GP LLC			3.4%	261,923
Biotechnology Value Fund II LP			2.5%	197,667
BVF II GP LLC			2.5%	197,667
Biotechnology Value Trading Fund OS LP			0.4%	33,116
BVF Partners OS Ltd.			0.4%	33,116
BVF GP Holdings LLC			5.9%	459,590
BVF Partners L P/IL			6.4%	500,000
BVF Inc/IL			6.4%	500,000
Lampert Mark N			6.4%	500,000
Monte Rosa Therapeutics, Inc. 13G/A GLUE · 61225M102	GLUE	61225M102	6.3%	5,085,886	13G/A	5/15/2026 Event 3/31/2026
Biotechnology Value Fund L P			3.4%	2,716,569
BVF I GP LLC			3.4%	2,716,569
Biotechnology Value Fund II LP			2.5%	1,986,984
BVF II GP LLC			2.5%	1,986,984
Biotechnology Value Trading Fund OS LP			0.4%	306,361
BVF Partners OS Ltd.			0.4%	306,361
BVF GP Holdings LLC			5.8%	4,703,553
BVF Partners L P/IL			6.3%	5,085,886
BVF Inc/IL			6.3%	5,085,886
Lampert Mark N			6.3%	5,085,886
4D Molecular Therapeutics, Inc. 13G/A FDMT · 35104E100	FDMT	35104E100	10.0%	5,346,519	13G/A	5/15/2026 Event 3/31/2026
Biotechnology Value Fund L P			7.3%	3,907,517
BVF I GP LLC			7.3%	3,907,517
Biotechnology Value Fund II LP			2.1%	1,093,101
BVF II GP LLC			2.1%	1,093,101
Biotechnology Value Trading Fund OS LP			0.6%	289,025
BVF Partners OS Ltd.			0.6%	289,025
BVF GP Holdings LLC			9.3%	5,000,618
BVF Partners L P/IL			10.0%	5,346,519
BVF Inc/IL			10.0%	5,346,519
Lampert Mark N			10.0%	5,346,519
Eledon Pharmaceuticals, Inc. 13G/A ELDN · 28617K101	ELDN	28617K101	10.0%	7,868,419	13G/A	5/15/2026 Event 3/31/2026
Biotechnology Value Fund L P			6.8%	5,382,084
BVF I GP LLC			6.8%	5,382,084
Biotechnology Value Fund II LP			2.7%	2,057,090
BVF II GP LLC			2.7%	2,057,090
Biotechnology Value Trading Fund OS LP			0.4%	301,588
BVF Partners OS Ltd.			0.4%	301,588
BVF GP Holdings LLC			9.4%	7,439,174
BVF Partners L P/IL			10.0%	7,868,419
BVF Inc/IL			10.0%	7,868,419
Lampert Mark N			10.0%	7,868,419
Compass Therapeutics, Inc. 13G/A CMPX · 20454B104	CMPX	20454B104	4.3%	7,764,842	13G/A	5/15/2026 Event 3/31/2026
Biotechnology Value Fund L P			2.3%	4,142,020
BVF I GP LLC			2.3%	4,142,020
Biotechnology Value Fund II LP			1.7%	3,028,951
BVF II GP LLC			1.7%	3,028,951
Biotechnology Value Trading Fund OS LP			0.3%	476,311
BVF Partners OS Ltd.			0.3%	476,311
BVF GP Holdings LLC			4.0%	7,170,971
BVF Partners L P/IL			4.3%	7,764,842
BVF Inc/IL			4.3%	7,764,842
Lampert Mark N			4.3%	7,764,842
Annexon, Inc. 13G/A ANNX · 03589W102	ANNX	03589W102	5.4%	8,698,173	13G/A	5/15/2026 Event 3/31/2026
Biotechnology Value Fund L P			2.9%	4,644,823
BVF I GP LLC			2.9%	4,644,823
Biotechnology Value Fund II LP			2.1%	3,399,850
BVF II GP LLC			2.1%	3,399,850
Biotechnology Value Trading Fund OS LP			0.3%	522,906
BVF Partners OS Ltd.			0.3%	522,906
BVF GP Holdings LLC			5.0%	8,044,673
BVF Partners L P/IL			5.4%	8,698,173
BVF Inc/IL			5.4%	8,698,173
Lampert Mark N			5.4%	8,698,173
Sutro Biopharma, Inc. 13G STRO · 869367201	STRO	869367201	7.6%	1,251,788	13G	2/18/2026 Event 2/10/2026
Biotechnology Value Fund L P			4.1%	668,693
BVF I GP LLC			4.1%	668,693
Biotechnology Value Fund II LP			3.0%	488,916
BVF II GP LLC			3.0%	488,916
Biotechnology Value Trading Fund OS LP			0.5%	75,359
BVF Partners OS Ltd.			0.5%	75,359
BVF GP Holdings LLC			7.0%	1,157,609
BVF Partners L P/IL			7.6%	1,251,788
BVF Inc/IL			7.6%	1,251,788
Lampert Mark N			7.6%	1,251,788
Xencor Inc 13G/A XNCR · 98401F105	XNCR	98401F105	10.0%	7,133,720	13G/A	2/17/2026 Event 12/31/2025
Biotechnology Value Fund L P			5.3%	3,798,627
BVF I GP LLC			5.3%	3,798,627
Biotechnology Value Fund II LP			3.9%	2,787,735
BVF II GP LLC			3.9%	2,787,735
Biotechnology Value Trading Fund OS LP			0.6%	439,372
BVF Partners OS Ltd.			0.6%	439,372
BVF GP Holdings LLC			9.2%	6,586,362
BVF Partners L P/IL			10.0%	7,133,720
BVF Inc/IL			10.0%	7,133,720
Lampert Mark N			10.0%	7,133,720
X4 Pharmaceuticals, Inc 13G/A XFOR · 98420X202	XFOR	98420X202	3.9%	3,411,993	13G/A	2/17/2026 Event 12/31/2025
Biotechnology Value Fund L P			2.1%	1,827,005
BVF I GP LLC			2.1%	1,827,005
Biotechnology Value Fund II LP			1.5%	1,339,509
BVF II GP LLC			1.5%	1,339,509
Biotechnology Value Trading Fund OS LP			0.2%	194,535
BVF Partners OS Ltd.			0.2%	194,535
BVF GP Holdings LLC			3.6%	3,166,514
BVF Partners L P/IL			3.9%	3,411,993
BVF Inc/IL			3.9%	3,411,993
Lampert Mark N			3.9%	3,411,993
Septerna, Inc. 13G/A SEPN · 81734D104	SEPN	81734D104	3.8%	1,720,782	13G/A	2/17/2026 Event 12/31/2025
Biotechnology Value Fund L P			2.0%	919,814
BVF I GP LLC			2.0%	919,814
Biotechnology Value Fund II LP			1.5%	671,492
BVF II GP LLC			1.5%	671,492
Biotechnology Value Trading Fund OS LP			0.2%	104,119
BVF Partners OS Ltd.			0.2%	104,119
BVF GP Holdings LLC			3.6%	1,591,306
BVF Partners L P/IL			3.8%	1,720,782
BVF Inc/IL			3.8%	1,720,782
Lampert Mark N			3.8%	1,720,782
SAB Biotherapeutics, Inc. 13G/A SABS · 78397T202	SABS	78397T202	9.1%	4,761,906	13G/A	2/17/2026 Event 12/31/2025
Biotechnology Value Fund L P			5.1%	2,540,159
BVF I GP LLC			5.1%	2,540,159
Biotechnology Value Fund II LP			3.9%	1,931,905
BVF II GP LLC			3.9%	1,931,905
Biotechnology Value Trading Fund OS LP			0.5%	225,556
BVF Partners OS Ltd.			0.5%	225,556
BVF GP Holdings LLC			8.6%	4,472,064
BVF Partners L P/IL			9.1%	4,761,906
BVF Inc/IL			9.1%	4,761,906
Lampert Mark N			9.1%	4,761,906
Structure Therapeutics Inc. 13G/A GPCR · 86366E106	GPCR	86366E106	4.9%	10,437,066	13G/A	2/17/2026 Event 12/31/2025
Biotechnology Value Fund L P			2.6%	5,583,855
BVF I GP LLC			2.6%	5,583,855
Biotechnology Value Fund II LP			1.9%	4,053,954
BVF II GP LLC			1.9%	4,053,954
Biotechnology Value Trading Fund OS LP			0.3%	643,536
BVF Partners OS Ltd.			0.3%	643,536
BVF GP Holdings LLC			4.5%	9,637,809
BVF Partners L P/IL			4.9%	10,437,066
BVF Inc/IL			4.9%	10,437,066
Lampert Mark N			4.9%	10,437,066
Zymeworks Inc. 13G/A ZYME · 98985Y108	ZYME	98985Y108	5.2%	3,938,641	13G/A	11/14/2025 Event 9/30/2025
Biotechnology Value Fund L P			2.7%	2,045,162
BVF I GP LLC			2.7%	2,045,162
Biotechnology Value Fund II LP			2.1%	1,601,489
BVF II GP LLC			2.1%	1,601,489
Biotechnology Value Trading Fund OS LP			0.3%	212,898
BVF Partners OS Ltd.			0.3%	212,898
BVF GP Holdings LLC			4.9%	3,646,651
BVF Partners L P/IL			5.2%	3,938,641
BVF Inc/IL			5.2%	3,938,641
Lampert Mark N			5.2%	3,938,641
RAPT Therapeutics, Inc. 13G/A RAPT · 75382E109	RAPT	75382E109	0%	0	13G/A	11/14/2025 Event 9/30/2025
Biotechnology Value Fund L P			0%	0
BVF I GP LLC			0%	0
Biotechnology Value Fund II LP			0%	0
BVF II GP LLC			0%	0
Biotechnology Value Trading Fund OS LP			0%	0
BVF Partners OS Ltd.			0%	0
BVF GP Holdings LLC			0%	0
BVF Partners L P/IL			0%	0
BVF Inc/IL			0%	0
Lampert Mark N			0%	0
Protagonist Therapeutics, Inc 13G/A PTGX · 74366E102	PTGX	74366E102	4.1%	2,560,916	13G/A	11/14/2025 Event 9/30/2025
Biotechnology Value Fund L P			2.1%	1,323,333
BVF I GP LLC			2.1%	1,323,333
Biotechnology Value Fund II LP			1.7%	1,045,774
BVF II GP LLC			1.7%	1,045,774
Biotechnology Value Trading Fund OS LP			0.2%	140,917
BVF Partners OS Ltd.			0.2%	140,917
BVF GP Holdings LLC			3.8%	2,369,107
BVF Partners L P/IL			4.1%	2,560,916
BVF Inc/IL			4.1%	2,560,916
Lampert Mark N			4.1%	2,560,916
Mirum Pharmaceuticals, Inc. 13G/A MIRM · 604749101	MIRM	604749101	3.0%	1,495,290	13G/A	11/14/2025 Event 9/30/2025
Biotechnology Value Fund L P			1.5%	772,595
BVF I GP LLC			1.5%	772,595
Biotechnology Value Fund II LP			1.2%	610,666
BVF II GP LLC			1.2%	610,666
Biotechnology Value Trading Fund OS LP			0.2%	82,238
BVF Partners OS Ltd.			0.2%	82,238
BVF GP Holdings LLC			2.8%	1,383,261
BVF Partners L P/IL			3.0%	1,495,290
BVF Inc/IL			3.0%	1,495,290
Lampert Mark N			3.0%	1,495,290
Kura Oncology, Inc. 13G/A KURA · 50127T109	KURA	50127T109	10.0%	8,677,018	13G/A	11/14/2025 Event 9/30/2025
Biotechnology Value Fund L P			5.1%	4,416,545
BVF I GP LLC			5.1%	4,416,545
Biotechnology Value Fund II LP			4.2%	3,640,106
BVF II GP LLC			4.2%	3,640,106
Biotechnology Value Trading Fund OS LP			0.5%	446,606
BVF Partners OS Ltd.			0.5%	446,606
BVF GP Holdings LLC			9.3%	8,056,651
BVF Partners L P/IL			10.0%	8,677,018
BVF Inc/IL			10.0%	8,677,018
Lampert Mark N			10.0%	8,677,018
Forte Biosciences, Inc. 13G/A FBRX · 34962G208	FBRX	34962G208	0.5%	65,350	13G/A	11/14/2025 Event 9/30/2025
Biotechnology Value Fund L P			0.3%	33,291
BVF I GP LLC			0.3%	33,291
Biotechnology Value Fund II LP			0.2%	27,232
BVF II GP LLC			0.2%	27,232
Biotechnology Value Trading Fund OS LP			<0.1%	3,468
BVF Partners OS Ltd.			<0.1%	3,468
BVF GP Holdings LLC			0.5%	60,523
BVF Partners L P/IL			0.5%	65,350
BVF Inc/IL			0.5%	65,350
Lampert Mark N			0.5%	65,350
Celcuity Inc. 13G/A CELC · 15102K100	CELC	15102K100	1.6%	658,421	13G/A	11/14/2025 Event 9/30/2025
Biotechnology Value Fund L P			0.8%	340,278
BVF I GP LLC			0.8%	340,278
Biotechnology Value Fund II LP			0.6%	268,775
BVF II GP LLC			0.6%	268,775
Biotechnology Value Trading Fund OS LP			0.1%	36,270
BVF Partners OS Ltd.			0.1%	36,270
BVF GP Holdings LLC			1.4%	609,053
BVF Partners L P/IL			1.6%	658,421
BVF Inc/IL			1.6%	658,421
Lampert Mark N			1.6%	658,421
NewcelX Ltd. 13G/A NCEL · H5835A109	NCEL	H5835A109	0.6%	28,732	13G/A	11/4/2025 Event 10/31/2025
Biotechnology Value Fund L P			0.3%	15,196
BVF I GP LLC			0.3%	15,196
Biotechnology Value Fund II LP			0.3%	11,746
BVF II GP LLC			0.3%	11,746
Biotechnology Value Trading Fund OS LP			<0.1%	1,334
BVF Partners OS Ltd.			<0.1%	1,334
BVF GP Holdings LLC			0.6%	26,942
BVF Partners L P/IL			0.6%	28,732
BVF Inc/IL			0.6%	28,732
Lampert Mark N			0.6%	28,732
Cidara Therapeutics, Inc. 13G/A CDTX · 171757206	CDTX	171757206	4.4%	1,189,165	13G/A	10/17/2025 Event 10/15/2025
Biotechnology Value Fund L P			2.3%	635,200
BVF I GP LLC			2.3%	635,200
Biotechnology Value Fund II LP			1.7%	461,474
BVF II GP LLC			1.7%	461,474
Biotechnology Value Trading Fund OS LP			0.3%	73,866
BVF Partners OS Ltd.			0.3%	73,866
BVF GP Holdings LLC			4.0%	1,096,674
BVF Partners L P/IL			4.4%	1,189,165
BVF Inc/IL			4.4%	1,189,165
Lampert Mark N			4.4%	1,189,165
Vigil Neuroscience, Inc. 13G/A VIGL · 92673K108	VIGL	92673K108	0%	0	13G/A	8/14/2025 Event 6/30/2025
Biotechnology Value Fund L P			0%	0
BVF I GP LLC			0%	0
Biotechnology Value Fund II LP			0%	0
BVF II GP LLC			0%	0
Biotechnology Value Trading Fund OS LP			0%	0
BVF Partners OS Ltd.			0%	0
BVF GP Holdings LLC			0%	0
BVF Partners L P/IL			0%	0
BVF Inc/IL			0%	0
Lampert Mark N			0%	0
Verve Therapeutics, Inc. 13G/A VERV · 92539P101	VERV	92539P101	0%	0	13G/A	8/14/2025 Event 6/30/2025
Biotechnology Value Fund L P			0%	0
BVF I GP LLC			0%	0
Biotechnology Value Fund II LP			0%	0
BVF II GP LLC			0%	0
Biotechnology Value Trading Fund OS LP			0%	0
BVF Partners OS Ltd.			0%	0
BVF GP Holdings LLC			0%	0
BVF Partners L P/IL			0%	0
BVF Inc/IL			0%	0
Lampert Mark N			0%	0
Unicycive Therapeutics, Inc. 13G/A UNCY · 90466Y202	UNCY	90466Y202	10.0%	1,417,117	13G/A	8/14/2025 Event 6/30/2025
Biotechnology Value Fund L P			5.7%	777,308
BVF I GP LLC			5.7%	777,308
Biotechnology Value Fund II LP			4.4%	591,650
BVF II GP LLC			4.4%	591,650
Biotechnology Value Trading Fund OS LP			0.3%	35,480
BVF Partners OS Ltd.			0.3%	35,480
BVF GP Holdings LLC			9.7%	1,368,958
BVF Partners L P/IL			10.0%	1,417,117
BVF Inc/IL			10.0%	1,417,117
Lampert Mark N			10.0%	1,417,117
iTeos Therapeutics, Inc. 13G/A ITOS · 46565G104	ITOS	46565G104	0%	0	13G/A	8/14/2025 Event 6/30/2025
Biotechnology Value Fund L P			0%	0
BVF I GP LLC			0%	0
Biotechnology Value Fund II LP			0%	0
BVF II GP LLC			0%	0
Biotechnology Value Trading Fund OS LP			0%	0
BVF Partners OS Ltd.			0%	0
BVF GP Holdings LLC			0%	0
BVF Partners L P/IL			0%	0
BVF Inc/IL			0%	0
Lampert Mark N			0%	0
Crescent Biopharma, Inc. 13G/A CBIO · G2545C104	CBIO	G2545C104	10.0%	1,387,863	13G/A	8/14/2025 Event 6/30/2025
Biotechnology Value Fund L P			5.1%	707,116
BVF I GP LLC			5.1%	707,116
Biotechnology Value Fund II LP			4.3%	593,740
BVF II GP LLC			4.3%	593,740
Biotechnology Value Trading Fund OS LP			0.4%	62,383
BVF Partners OS Ltd.			0.4%	62,383
BVF GP Holdings LLC			9.4%	1,300,856
BVF Partners L P/IL			10.0%	1,387,863
BVF Inc/IL			10.0%	1,387,863
Lampert Mark N			10.0%	1,387,863
Verastem, Inc. 13G/A VSTM · 92337C203	VSTM	92337C203	3.9%	2,500,000	13G/A	8/13/2025 Event 8/11/2025
Biotechnology Value Fund L P			2.2%	1,396,290
BVF I GP LLC			2.2%	1,396,290
Biotechnology Value Fund II LP			1.5%	933,240
BVF II GP LLC			1.5%	933,240
Biotechnology Value Trading Fund OS LP			0.2%	100,150
BVF Partners OS Ltd.			0.2%	100,150
BVF GP Holdings LLC			3.6%	2,329,530
BVF Partners L P/IL			3.9%	2,500,000
BVF Inc/IL			3.9%	2,500,000
Lampert Mark N			3.9%	2,500,000
Ovid Therapeutics Inc. 13G/A OVID · 690469101	OVID	690469101	0%	0	13G/A	7/21/2025 Event 7/17/2025
Biotechnology Value Fund L P			0%	0
BVF I GP LLC			0%	0
Biotechnology Value Fund II LP			0%	0
BVF II GP LLC			0%	0
Biotechnology Value Trading Fund OS LP			0%	0
BVF Partners OS Ltd.			0%	0
BVF GP Holdings LLC			0%	0
BVF Partners L P/IL			0%	0
BVF Inc/IL			0%	0
Lampert Mark N			0%	0
CytomX Therapeutics, Inc. 13G/A CTMX · 23284F105	CTMX	23284F105	3.5%	5,769,231	13G/A	7/9/2025 Event 7/3/2025
Biotechnology Value Fund L P			1.9%	3,074,013
BVF I GP LLC			1.9%	3,074,013
Biotechnology Value Fund II LP			1.5%	2,351,446
BVF II GP LLC			1.5%	2,351,446
Biotechnology Value Trading Fund OS LP			0.2%	270,616
BVF Partners OS Ltd.			0.2%	270,616
BVF GP Holdings LLC			3.3%	5,425,459
BVF Partners L P/IL			3.5%	5,769,231
BVF Inc/IL			3.5%	5,769,231
Lampert Mark N			3.5%	5,769,231
Allakos Inc. 13G/A ALLK · 01671P100	ALLK	01671P100	0%	0	13G/A	5/19/2025 Event 5/15/2025
Biotechnology Value Fund L P			0%	0
BVF I GP LLC			0%	0
Biotechnology Value Fund II LP			0%	0
BVF II GP LLC			0%	0
Biotechnology Value Trading Fund OS LP			0%	0
BVF Partners OS Ltd.			0%	0
BVF GP Holdings LLC			0%	0
BVF Partners L P/IL			0%	0
BVF Inc/IL			0%	0
Lampert Mark N			0%	0
GH Research PLC 13G/A GHRS · G3855L106	GHRS	G3855L106	14.2%	8,827,712	13G/A	5/15/2025 Event 3/31/2025
Biotechnology Value Fund L P			7.4%	4,599,019
BVF I GP LLC			7.4%	4,599,019
Biotechnology Value Fund II LP			5.8%	3,605,399
BVF II GP LLC			5.8%	3,605,399
Biotechnology Value Trading Fund OS LP			1.0%	619,881
BVF Partners OS Ltd.			1.0%	619,881
BVF GP Holdings LLC			13.2%	8,204,418
BVF Partners L P/IL			14.2%	8,827,712
BVF Inc/IL			14.2%	8,827,712
Lampert Mark N			14.2%	8,827,712
Elevation Oncology, Inc. 13G/A ELEV · 28623U101	ELEV	28623U101	7.0%	4,440,000	13G/A	5/15/2025 Event 3/31/2025
Biotechnology Value Fund L P			3.9%	2,374,712
BVF I GP LLC			3.9%	2,374,712
Biotechnology Value Fund II LP			3.0%	1,826,364
BVF II GP LLC			3.0%	1,826,364
Biotechnology Value Trading Fund OS LP			0.4%	210,388
BVF Partners OS Ltd.			0.4%	210,388
BVF GP Holdings LLC			6.6%	4,201,076
BVF Partners L P/IL			7.0%	4,440,000
BVF Inc/IL			7.0%	4,440,000
Lampert Mark N			7.0%	4,440,000
Third Harmonic Bio, Inc. 13G/A THRD · 88427A107	THRD	88427A107	0%	0	13G/A	4/16/2025 Event 4/14/2025
Biotechnology Value Fund L P			0%	0
BVF I GP LLC			0%	0
Biotechnology Value Fund II LP			0%	0
BVF II GP LLC			0%	0
Biotechnology Value Trading Fund OS LP			0%	0
BVF Partners OS Ltd.			0%	0
BVF GP Holdings LLC			0%	0
BVF Partners L P/IL			0%	0
BVF Inc/IL			0%	0
Lampert Mark N			0%	0
Vistagen Therapeutics, Inc. 13G/A VTGN · 92840H400	VTGN	92840H400	10.0%	3,084,324	13G/A	2/14/2025 Event 12/31/2024
Biotechnology Value Fund L P			5.4%	1,589,495
BVF I GP LLC			5.4%	1,589,495
Biotechnology Value Fund II LP			4.4%	1,289,734
BVF II GP LLC			4.4%	1,289,734
Biotechnology Value Trading Fund OS LP			0.6%	158,606
BVF Partners OS Ltd.			0.6%	158,606
BVF GP Holdings LLC			9.4%	2,879,229
BVF Partners L P/IL			10.0%	3,084,324
BVF Inc/IL			10.0%	3,084,324
Lampert Mark N			10.0%	3,084,324
Ikena Oncology, Inc. 13G/A IKNA · 45175G108	IKNA	45175G108	8.3%	4,006,564	13G/A	2/14/2025 Event 12/31/2024
Biotechnology Value Fund L P			4.3%	2,066,854
BVF I GP LLC			4.3%	2,066,854
Biotechnology Value Fund II LP			3.5%	1,669,108
BVF II GP LLC			3.5%	1,669,108
Biotechnology Value Trading Fund OS LP			0.4%	208,765
BVF Partners OS Ltd.			0.4%	208,765
BVF GP Holdings LLC			7.7%	3,735,962
BVF Partners L P/IL			8.3%	4,006,564
BVF Inc/IL			8.3%	4,006,564
Lampert Mark N			8.3%	4,006,564
89bio, Inc. 13G/A ETNB · 282559103	ETNB	282559103	3.6%	4,333,885	13G/A	2/14/2025 Event 12/31/2024
Biotechnology Value Fund L P			1.9%	2,227,427
BVF I GP LLC			1.9%	2,227,427
Biotechnology Value Fund II LP			1.5%	1,799,517
BVF II GP LLC			1.5%	1,799,517
Biotechnology Value Trading Fund OS LP			0.2%	223,979
BVF Partners OS Ltd.			0.2%	223,979
BVF GP Holdings LLC			3.4%	4,026,944
BVF Partners L P/IL			3.6%	4,333,885
BVF Inc/IL			3.6%	4,333,885
Lampert Mark N			3.6%	4,333,885
enGene Holdings Inc. 13G/A ENGN · 29286M105	ENGN	29286M105	1.8%	945,402	13G/A	1/29/2025 Event 1/27/2025
Biotechnology Value Fund L P			1.0%	505,835
BVF I GP LLC			1.0%	505,835
Biotechnology Value Fund II LP			0.7%	383,352
BVF II GP LLC			0.7%	383,352
Biotechnology Value Trading Fund OS LP			0.1%	43,786
BVF Partners OS Ltd.			0.1%	43,786
BVF GP Holdings LLC			1.7%	889,187
BVF Partners L P/IL			1.8%	945,402
BVF Inc/IL			1.8%	945,402
Lampert Mark N			1.8%	945,402

Includes filings since 12/18/2024, when the SEC began requiring structured 13D and 13G data.