Investors who own more than 5% of a class must file a Schedule 13D or 13G. Each filer's latest filing for 20454B104 since 12/18/2024, largest first.
| Filer | % of Class | Filed | ||
|---|---|---|---|---|
|
Tang Capital Management LLC
13G/A
|
10.0% |
11/14/2025
Event 9/30/2025
|
||
| Tang Capital Management, LLC | 10.0% | |||
| Kevin Tang | 10.0% | |||
| Tang Capital Partners, LP | 6.0% | |||
| Tang Capital Partners International, LP | 3.2% | |||
| Tang Capital Partners III, Inc | 0.6% | |||
| Tang Capital Partners IV, Inc | 0.2% | |||
|
Orbimed Advisors LLC
13D/A
|
8.9% |
8/15/2025
Event 8/13/2025
|
||
| Orbimed Advisors LLC | 8.9% | |||
| Orbimed Capital GP V LLC | 8.9% | |||
|
Suvretta Capital Management, LLC
13G/A
|
8.2% |
8/21/2025
Event 8/13/2025
|
||
| Suvretta Capital Management, LLC | 8.2% | |||
| Averill Master Fund, Ltd. | 7.1% | |||
| Aaron Cowen | 8.2% | |||
| State Street Corp 13G | 5.5% |
8/7/2026
Event 6/30/2026
|
||
| BlackRock, Inc. 13G | 5.2% |
1/21/2026
Event 12/31/2025
|
||
| Under 5%, checked the "5 percent or less" box, or amended by a later filing (6) | ||||
|
Commander Aggregator, LP
13D/A
|
4.5% |
8/18/2025
Event 8/14/2025
|
||
| Commander Aggregator, LP | 4.5% | |||
| Enavate Sciences, LP | 4.5% | |||
| Enavate Sciences GP, LLC | 4.5% | |||
| Enavate Sciences Holdings, LLC | 4.5% | |||
|
Adage Capital Partners GP, L.L.C.
13G/A
|
4.4% |
2/12/2025
Event 12/31/2024
|
||
| Adage Capital Management, L.P. | 4.4% | |||
| Adage Capital Partners GP, L.L.C. | 0% | |||
| Robert Atchinson | 4.4% | |||
| Phillip Gross | 4.4% | |||
|
Biotechnology Value Fund L P
13G/A
|
4.3% |
5/15/2026
Event 3/31/2026
|
||
| Biotechnology Value Fund L P | 2.3% | |||
| BVF I GP LLC | 2.3% | |||
| Biotechnology Value Fund II LP | 1.7% | |||
| BVF II GP LLC | 1.7% | |||
| Biotechnology Value Trading Fund OS LP | 0.3% | |||
| BVF Partners OS Ltd. | 0.3% | |||
| BVF GP Holdings LLC | 4.0% | |||
| BVF Partners L P/IL | 4.3% | |||
| BVF Inc/IL | 4.3% | |||
| Lampert Mark N | 4.3% | |||
| MPM BioImpact LLC 13G/A | 4.1% |
8/12/2025
Event 6/30/2025
|
||
|
Vivo Opportunity Fund Holdings, L.P.
13G/A
|
4.0% |
8/14/2026
Event 6/30/2026
|
||
| Vivo Opportunity Fund Holdings, L.P. | 4.0% | |||
| Vivo Opportunity, LLC | 4.0% | |||
| Vivo Opportunity Cayman Fund, L.P. | 0.3% | |||
| Vivo Opportunity Cayman, LLC | 0.3% | |||
|
Blackstone Holdings II L.P.
13G/A
|
3.4% |
2/13/2026
Event 12/31/2025
|
||
| Blackstone Annex Master Fund L.P. | 1.4% | |||
| Spruce Street Aggregator L.P. | 2.1% | |||
| Blackstone Alternative Asset Management Associates LLC | 3.4% | |||
| Blackstone Holdings II L.P. | 3.4% | |||
| Blackstone Holdings I/II GP L.L.C. | 3.4% | |||
| Blackstone Inc. | 3.4% | |||
| Blackstone Group Management L.L.C. | 3.4% | |||
| Stephen A. Schwarzman | 3.4% | |||
| Period | Filings | Shares, Excl. Options | Value, Excl. Options |
|---|---|---|---|
| 2026 Q3 | 2 | 1.10 k | $1.15 k |
| 2026 Q2 | 222 | 166 M | $431 M |
| 2026 Q1 | 211 | 173 M | $919 M |
| 2025 Q4 | 175 | 164 M | $882 M |
| 2025 Q3 | 131 | 153 M | $536 M |
| 2025 Q2 | 108 | 108 M | $282 M |
| 2025 Q1 | 132 | 108 M | $206 M |
| 2024 Q4 | 94 | 101 M | $147 M |
| 2024 Q3 | 81 | 92.2 M | $170 M |
| 2024 Q2 | 85 | 93.1 M | $93.6 M |
| 2024 Q1 | 82 | 94.9 M | $188 M |
| 2023 Q4 | 81 | 86.6 M | $135 M |
| 2023 Q3 | 78 | 89.7 M | $177 M |
| 2023 Q2 | 74 | 90.5 M | $288 M |
| 2023 Q1 | 74 | 81.5 M | $267 M |
| 2022 Q4 | 57 | 80.1 M | $403 M |
| 2022 Q3 | 40 | 67.4 M | $154 M |
| 2022 Q2 | 35 | 61.9 M | $164 M |
| 2022 Q1 | 35 | 62.4 M | $85.4 M |
| 2021 Q4 | 38 | 63.6 M | $202 M |