Investors who own more than 5% of a class must file a Schedule 13D or 13G. Each filer's latest filing for 004225108 since 12/18/2024, largest first.
| Filer | % of Class | Filed | ||
|---|---|---|---|---|
|
Baker Bros. Advisors LP
13D/A
|
25.4% |
2/26/2026
Event 2/24/2026
|
||
| Baker Bros. Advisors LP | 25.3% | |||
| Baker Bros. Advisors (GP) LLC | 25.3% | |||
| Julian C. Baker | 25.4% | |||
| Felix J. Baker | 25.4% | |||
| FBB3 LLC | <0.1% | |||
| BlackRock, Inc. 13G/A | 11.9% |
2/7/2025
Event 1/31/2025
|
||
| State Street Corp 13G | 5.3% |
8/7/2026
Event 6/30/2026
|
||
| Vanguard Portfolio Management LLC 13G | 5.2% |
4/28/2026
Event 3/31/2026
|
||
| Under 5%, checked the "5 percent or less" box, or amended by a later filing (2) | ||||
|
RTW Investments, LP
13G/A
|
4.2% |
11/14/2025
Event 9/30/2025
|
||
| RTW Investments, LP | 4.2% | |||
| Roderick Wong | 4.2% | |||
| Vanguard Group Inc 13G/A | 0% |
3/26/2026
Event 3/13/2026
|
||
| Period | Filings | Shares, Excl. Options | Value, Excl. Options |
|---|---|---|---|
| 2026 Q3 | 34 | 1.08 M | $21.8 M |
| 2026 Q2 | 370 | 172 M | $4.40 B |
| 2026 Q1 | 364 | 165 M | $3.67 B |
| 2025 Q4 | 355 | 166 M | $4.44 B |
| 2025 Q3 | 362 | 168 M | $3.59 B |
| 2025 Q2 | 334 | 173 M | $3.73 B |
| 2025 Q1 | 340 | 173 M | $2.87 B |
| 2024 Q4 | 310 | 163 M | $3.00 B |
| 2024 Q3 | 274 | 157 M | $2.41 B |
| 2024 Q2 | 286 | 164 M | $2.67 B |
| 2024 Q1 | 303 | 166 M | $3.07 B |
| 2023 Q4 | 305 | 163 M | $5.09 B |
| 2023 Q3 | 274 | 156 M | $3.26 B |
| 2023 Q2 | 251 | 159 M | $3.81 B |
| 2023 Q1 | 252 | 158 M | $2.98 B |
| 2022 Q4 | 246 | 164 M | $2.88 B |
| 2022 Q3 | 240 | 153 M | $2.50 B |
| 2022 Q2 | 268 | 151 M | $2.13 B |
| 2022 Q1 | 286 | 148 M | $3.58 B |
| 2021 Q4 | 278 | 150 M | $3.51 B |
| 2021 Q3 | 256 | 145 M | $2.41 B |
| 2021 Q2 | 262 | 148 M | $3.61 B |
| 2021 Q1 | 313 | 147 M | $3.79 B |
| 2020 Q4 | 331 | 148 M | $7.93 B |
| 2020 Q3 | 295 | 150 M | $6.19 B |
| 2020 Q2 | 322 | 153 M | $7.41 B |
| 2020 Q1 | 268 | 155 M | $6.56 B |
| 2019 Q4 | 304 | 152 M | $6.48 B |
| 2019 Q3 | 263 | 148 M | $5.32 B |
| 2019 Q2 | 224 | 139 M | $3.72 B |
| 2019 Q1 | 221 | 138 M | $3.70 B |
| 2018 Q4 | 209 | 141 M | $2.28 B |
| 2018 Q3 | 214 | 123 M | $2.56 B |
| 2018 Q2 | 213 | 119 M | $1.82 B |
| 2018 Q1 | 218 | 124 M | $2.78 B |
| 2017 Q4 | 234 | 120 M | $3.62 B |
| 2017 Q3 | 242 | 118 M | $4.45 B |
| 2017 Q2 | 228 | 120 M | $3.34 B |
| 2017 Q1 | 246 | 120 M | $4.12 B |
| 2016 Q4 | 270 | 121 M | $3.50 B |
| 2016 Q3 | 267 | 118 M | $3.75 B |
| 2016 Q2 | 257 | 111 M | $3.61 B |
| 2016 Q1 | 261 | 111 M | $3.09 B |
| 2015 Q4 | 244 | 102 M | $3.64 B |
| 2015 Q3 | 210 | 101 M | $3.39 B |
| 2015 Q2 | 212 | 98.3 M | $4.12 B |
| 2015 Q1 | 214 | 97.3 M | $3.17 B |
| 2014 Q4 | 201 | 96.9 M | $3.08 B |
| 2014 Q3 | 185 | 94.2 M | $2.33 B |
| 2014 Q2 | 182 | 97.4 M | $2.20 B |
| 2014 Q1 | 191 | 90.9 M | $2.21 B |