| Quarter | Holdings | Value ($000) | Form Type | Date Filed | Filing ID | Name |
|---|---|---|---|---|---|---|
| Q1 2023 | 105 | 18,379,748 | 13F-HR | 5/15/2023 | 000110465923060720 | BAKER BROS. ADVISORS LP |
| Q4 2022 | 113 | 16,651,382 | 13F-HR | 2/14/2023 | 000110465923021551 | BAKER BROS. ADVISORS LP |
| Q3 2022 | 115 | 15,269,446 | 13F-HR | 11/14/2022 | 000110465922118527 | BAKER BROS. ADVISORS LP |
| Q2 2022 | 117 | 17,626,987 | 13F-HR | 8/15/2022 | 000110465922091286 | BAKER BROS. ADVISORS LP |
| Q1 2022 | 118 | 17,403,462 | 13F-HR | 5/16/2022 | 000110465922061288 | BAKER BROS. ADVISORS LP |
| Q4 2021 | 121 | 20,553,592 | 13F-HR | 2/14/2022 | 000110465922022725 | BAKER BROS. ADVISORS LP |
| Q3 2021 | 122 | 22,771,634 | 13F-HR | 11/15/2021 | 000110465921139109 | BAKER BROS. ADVISORS LP |
| Q2 2021 | 120 | 22,769,898 | 13F-HR | 8/16/2021 | 000110465921106314 | BAKER BROS. ADVISORS LP |
| Q1 2021 | 126 | 23,065,323 | 13F-HR | 5/17/2021 | 000110465921068025 | BAKER BROS. ADVISORS LP |
| Q4 2020 | 126 | 26,543,637 | 13F-HR | 2/16/2021 | 000110465921023833 | BAKER BROS. ADVISORS LP |
| Q3 2020 | 120 | 25,025,928 | 13F-HR | 11/16/2020 | 000110465920125767 | BAKER BROS. ADVISORS LP |
| Q2 2020 | 114 | 22,670,991 | 13F-HR | 8/14/2020 | 000110465920095518 | BAKER BROS. ADVISORS LP |
| Q1 2020 | 110 | 16,236,233 | 13F-HR | 5/15/2020 | 000110465920062575 | BAKER BROS. ADVISORS LP |
| Q4 2019 | 99 | 18,809,854 | 13F-HR | 2/14/2020 | 000110465920021838 | BAKER BROS. ADVISORS LP |
| Q3 2019 | 109 | 14,699,689 | 13F-HR | 11/14/2019 | 000110465919064169 | BAKER BROS. ADVISORS LP |
| Q2 2019 | 103 | 14,714,211 | 13F-HR | 8/14/2019 | 000114420419040033 | BAKER BROS. ADVISORS LP |
| Q1 2019 | 96 | 15,621,759 | 13F-HR | 5/15/2019 | 000114420419026555 | BAKER BROS. ADVISORS LP |
| Q4 2018 | 93 | 12,212,527 | 13F-HR | 2/13/2019 | 000114420419007156 | BAKER BROS. ADVISORS LP |
| Q3 2018 | 97 | 15,181,170 | 13F-HR | 11/14/2018 | 000114420418059891 | BAKER BROS. ADVISORS LP |
| Q2 2018 | 119 | 13,308,803 | 13F-HR | 8/14/2018 | 000114420418044607 | BAKER BROS. ADVISORS LP |
| Q1 2018 | 114 | 11,797,988 | 13F-HR | 5/15/2018 | 000114420418028818 | BAKER BROS. ADVISORS LP |
| Q4 2017 | 123 | 11,537,077 | 13F-HR | 2/14/2018 | 000114420418008839 | BAKER BROS. ADVISORS LP |
| Q3 2017 | 121 | 12,330,918 | 13F-HR | 11/14/2017 | 000114420417058963 | BAKER BROS. ADVISORS LP |
| Q2 2017 | 120 | 11,438,426 | 13F-HR | 8/14/2017 | 000114420417043086 | BAKER BROS. ADVISORS LP |
| Q1 2017 | 119 | 12,220,691 | 13F-HR | 5/15/2017 | 000114420417027430 | BAKER BROS. ADVISORS LP |
| Q4 2016 | 133 | 10,200,965 | 13F-HR | 2/14/2017 | 000114420417008836 | BAKER BROS. ADVISORS LP |
| Q3 2016 | 134 | 11,019,928 | 13F-HR | 11/14/2016 | 000114420416134352 | BAKER BROS. ADVISORS LP |
| Q2 2016 | 135 | 9,537,918 | 13F-HR | 8/15/2016 | 000114420416119409 | BAKER BROS. ADVISORS LP |
| Q1 2016 | 134 | 9,482,104 | 13F-HR | 5/16/2016 | 000114420416102596 | BAKER BROS. ADVISORS LP |
| Q4 2015 | 133 | 12,071,272 | 13F-HR | 2/16/2016 | 000114420416082790 | BAKER BROS. ADVISORS LP |
| Q3 2015 | 133 | 10,823,762 | 13F-HR | 11/16/2015 | 000114420415065993 | BAKER BROS. ADVISORS LP |
| Q2 2015 | 126 | 11,400,413 | 13F-HR | 8/14/2015 | 000114420415049845 | BAKER BROS. ADVISORS LP |
| Q1 2015 | 130 | 12,022,854 | 13F-HR | 5/15/2015 | 000114420415031569 | BAKER BROS. ADVISORS LP |
| Q4 2014 | 121 | 9,797,208 | 13F-HR | 2/17/2015 | 000114420415010112 | BAKER BROS. ADVISORS LP |
| Q3 2014 | 110 | 7,940,514 | 13F-HR | 11/14/2014 | 000114420414068894 | BAKER BROS. ADVISORS LP |
| Q2 2014 | 107 | 8,164,077 | 13F-HR | 8/14/2014 | 000114420414050184 | BAKER BROS. ADVISORS LP |
| Q1 2014 | 108 | 7,867,925 | 13F-HR | 5/15/2014 | 000114420414031196 | BAKER BROS. ADVISORS LP |
| Q4 2013 | 95 | 7,095,729 | 13F-HR | 2/14/2014 | 000114420414009842 | BAKER BROS. ADVISORS LP |