Adage Capital Management, L.P.

13D and 13G Filings

13D/G filings: 13D on 2 securities, 13G on 147 securities
CIK: 0001535978
All SEC filings: View on sec.gov

Issuer	Symbol	CUSIP	% of Class	Shares	Form	Filed
SilverBox Corp V 13G SBXE · G8148S107	SBXE	G8148S107	6.4%	1,750,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			6.4%	1,750,000
Robert Atchinson			6.4%	1,750,000
Phillip Gross			6.4%	1,750,000
Vine Hill Capital Investment Corp. II 13G VHCPU · G9709D125	VHCPU	G9709D125	6.9%	1,575,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			6.9%	1,575,000
Robert Atchinson			6.9%	1,575,000
Phillip Gross			6.9%	1,575,000
Praxis Precision Medicines, Inc. 13G/A Amendment 4 PRAX · 74006W207	PRAX	74006W207	3.8%	965,313	13G/A Amendment 4	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			3.8%	965,313
Robert Atchinson			3.8%	965,313
Phillip Gross			3.8%	965,313
Terns Pharmaceuticals, Inc. 13G TERN · 880881107	TERN	880881107	5.1%	5,550,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			5.1%	5,550,000
Robert Atchinson			5.1%	5,550,000
Phillip Gross			5.1%	5,550,000
Twelve Seas Investment Co III 13G TWLV · G9145D101	TWLV	G9145D101	7.6%	1,350,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			7.6%	1,350,000
Robert Atchinson			7.6%	1,350,000
Phillip Gross			7.6%	1,350,000
Relmada Therapeutics, Inc. 13G RLMD · 75955J402	RLMD	75955J402	5.8%	4,270,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			5.8%	4,270,000
Robert Atchinson			5.8%	4,270,000
Phillip Gross			5.8%	4,270,000
Safeguard Acquisition Corp. 13G SAC · G77676107	SAC	G77676107	7.6%	1,800,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			7.6%	1,800,000
Robert Atchinson			7.6%	1,800,000
Phillip Gross			7.6%	1,800,000
Tango Therapeutics, Inc. 13G TNGX · 87583X109	TNGX	87583X109	7.9%	10,607,924	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			7.9%	10,607,924
Robert Atchinson			7.9%	10,607,924
Phillip Gross			7.9%	10,607,924
Traws Pharma, Inc. 13G TRAW · 68232V884	TRAW	68232V884	9.1%	730,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			9.1%	730,000
Robert Atchinson			9.1%	730,000
Phillip Gross			9.1%	730,000
Daedalus Special Acquisition Corp. 13G DSACU · G2616C124	DSACU	G2616C124	7.0%	1,800,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			7.0%	1,800,000
Robert Atchinson			7.0%	1,800,000
Phillip Gross			7.0%	1,800,000
Churchill Capital Corp XI 13G CCXIU · G2131A124	CCXIU	G2131A124	6.4%	2,700,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			6.4%	2,700,000
Robert Atchinson			6.4%	2,700,000
Phillip Gross			6.4%	2,700,000
Solid Biosciences Inc. 13G/A Amendment 2 SLDB · 83422E204	SLDB	83422E204	1.8%	1,400,000	13G/A Amendment 2	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			1.8%	1,400,000
Robert Atchinson			1.8%	1,400,000
Phillip Gross			1.8%	1,400,000
Amylyx Pharmaceuticals, Inc. 13G/A Amendment 3 AMLX · 03237H101	AMLX	03237H101	2.5%	2,777,055	13G/A Amendment 3	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			2.5%	2,777,055
Robert Atchinson			2.5%	2,777,055
Phillip Gross			2.5%	2,777,055
Abeona Therapeutics Inc. 13G/A Amendment 11 ABEO · 00289Y206	ABEO	00289Y206	0%	0	13G/A Amendment 11	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			0%	0
Robert Atchinson			0%	0
Phillip Gross			0%	0
EyePoint, Inc. 13G/A Amendment 6 EYPT · 30233G209	EYPT	30233G209	5.7%	4,700,000	13G/A Amendment 6	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			5.7%	4,700,000
Robert Atchinson			5.7%	4,700,000
Phillip Gross			5.7%	4,700,000
Wave Life Sciences Ltd. 13G/A Amendment 5 WVE · Y95308105	WVE	Y95308105	5.4%	9,786,061	13G/A Amendment 5	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			5.4%	9,786,061
Robert Atchinson			5.4%	9,786,061
Phillip Gross			5.4%	9,786,061
Monro, Inc. 13G/A Amendment 1 MNRO · 610236101	MNRO	610236101	4.99%	1,500,000	13G/A Amendment 1	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			4.99%	1,500,000
Robert Atchinson			4.99%	1,500,000
Phillip Gross			4.99%	1,500,000
Crane Harbor Acquisition Corp. II 13G CRAN · G25014104	CRAN	G25014104	7.6%	2,700,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			7.6%	2,700,000
Robert Atchinson			7.6%	2,700,000
Phillip Gross			7.6%	2,700,000
Nabors Industries Ltd. 13G NBR · G6359F137	NBR	G6359F137	8.0%	1,260,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			8.0%	1,260,000
Robert Atchinson			8.0%	1,260,000
Phillip Gross			8.0%	1,260,000
Metropolitan Bank Holding Corp. 13G MCB · 591774104	MCB	591774104	5.4%	559,479	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			5.4%	559,479
Robert Atchinson			5.4%	559,479
Phillip Gross			5.4%	559,479
Launchpad Cadenza Acquisition Corp I 13G LPCVU · G6001S123	LPCVU	G6001S123	5.4%	1,250,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			5.4%	1,250,000
Robert Atchinson			5.4%	1,250,000
Phillip Gross			5.4%	1,250,000
Viking Acquisition Corp I 13G VACI · G9582G104	VACI	G9582G104	7.6%	1,800,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			7.6%	1,800,000
Robert Atchinson			7.6%	1,800,000
Phillip Gross			7.6%	1,800,000
Leapfrog Acquisition Corporation 13G LFACU · G5414D129	LFACU	G5414D129	7.6%	1,125,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			7.6%	1,125,000
Robert Atchinson			7.6%	1,125,000
Phillip Gross			7.6%	1,125,000
Karyopharm Therapeutics Inc. 13G/A Amendment 1 KPTI · 48576U205	KPTI	48576U205	2.4%	436,736	13G/A Amendment 1	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			2.4%	436,736
Robert Atchinson			2.4%	436,736
Phillip Gross			2.4%	436,736
Insight Digital Partners II 13G DYOR · G4814G105	DYOR	G4814G105	7.8%	1,350,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			7.8%	1,350,000
Robert Atchinson			7.8%	1,350,000
Phillip Gross			7.8%	1,350,000
Tailwind 2.0 Acquisition Corp. 13G TDWD · G8662J111	TDWD	G8662J111	7.6%	1,350,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			7.6%	1,350,000
Robert Atchinson			7.6%	1,350,000
Phillip Gross			7.6%	1,350,000
Hall Chadwick Acquisition Corp 13G HCACU · G42386121	HCACU	G42386121	7.6%	1,620,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			7.6%	1,620,000
Robert Atchinson			7.6%	1,620,000
Phillip Gross			7.6%	1,620,000
Evolution Global Acquisition Corp 13G EVOX · G3226F101	EVOX	G3226F101	7.9%	1,890,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			7.9%	1,890,000
Robert Atchinson			7.9%	1,890,000
Phillip Gross			7.9%	1,890,000
Minerva Neurosciences, Inc. 13G NERV · 603380205	NERV	603380205	6.4%	2,838,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			6.4%	2,838,000
Robert Atchinson			6.4%	2,838,000
Phillip Gross			6.4%	2,838,000
Karbon Capital Partners Corp. 13G KBONU · G5225W126	KBONU	G5225W126	7.6%	2,700,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			7.6%	2,700,000
Robert Atchinson			7.6%	2,700,000
Phillip Gross			7.6%	2,700,000
Dynamix Corp III 13G DNMX · G2949T109	DNMX	G2949T109	7.8%	1,575,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			7.8%	1,575,000
Robert Atchinson			7.8%	1,575,000
Phillip Gross			7.8%	1,575,000
Apex Treasury Corp 13G APXT · G04104108	APXT	G04104108	6.5%	2,250,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			6.5%	2,250,000
Robert Atchinson			6.5%	2,250,000
Phillip Gross			6.5%	2,250,000
General Purpose Acquisition Corp. 13G GPACU · G3810N122	GPACU	G3810N122	8.7%	1,800,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			8.7%	1,800,000
Robert Atchinson			8.7%	1,800,000
Phillip Gross			8.7%	1,800,000
American Drive Acquisition Co 13G ADACU · G0R91M121	ADACU	G0R91M121	5.4%	1,250,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			5.4%	1,250,000
Robert Atchinson			5.4%	1,250,000
Phillip Gross			5.4%	1,250,000
Bain Capital GSS Investment Corp. 13G BCSS · G0R78B106	BCSS	G0R78B106	6.4%	3,000,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			6.4%	3,000,000
Robert Atchinson			6.4%	3,000,000
Phillip Gross			6.4%	3,000,000
Pasithea Therapeutics Corp. 13G KTTA · 70261F202	KTTA	70261F202	10.0%	2,329,749	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			10.0%	2,329,749
Robert Atchinson			10.0%	2,329,749
Phillip Gross			10.0%	2,329,749
Activate Energy Acquisition Corp. 13G AEAQU · G0081J129	AEAQU	G0081J129	7.6%	1,800,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			7.6%	1,800,000
Robert Atchinson			7.6%	1,800,000
Phillip Gross			7.6%	1,800,000
Lifezone Metals Ltd 13G LZM · G5568L109	LZM	G5568L109	5.9%	5,075,122	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			5.9%	5,075,122
Robert Atchinson			5.9%	5,075,122
Phillip Gross			5.9%	5,075,122
Invest Green Acquisition Corporation 13G IGACU · G4924G128	IGACU	G4924G128	7.5%	1,350,000	13G	2/12/2026 Event 12/31/2025
Adage Capital Management, L.P.			7.5%	1,350,000
Robert Atchinson			7.5%	1,350,000
Phillip Gross			7.5%	1,350,000
iBio, Inc. 13G IBIO · 451033708	IBIO	451033708	10.0%	2,181,422	13G	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			10.0%	2,181,422
Robert Atchinson			10.0%	2,181,422
Phillip Gross			10.0%	2,181,422
Inovio Pharmaceuticals, Inc. 13G INO · 45773H409	INO	45773H409	10.0%	5,517,650	13G	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			10.0%	5,517,650
Robert Atchinson			10.0%	5,517,650
Phillip Gross			10.0%	5,517,650
Sitio Royalties Corp. 13G/A Amendment 1 STR · 82983N108	STR	82983N108	0%	0	13G/A Amendment 1	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			0%	0
Robert Atchinson			0%	0
Phillip Gross			0%	0
Dynamix Corp 13G/A Amendment 1 DYNC · G2949D104	DYNC	G2949D104	0.8%	125,000	13G/A Amendment 1	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			0.8%	125,000
Robert Atchinson			0.8%	125,000
Phillip Gross			0.8%	125,000
Equillium, Inc. 13G EQ · 29446K106	EQ	29446K106	10.0%	6,012,624	13G	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			10.0%	6,012,624
Robert Atchinson			10.0%	6,012,624
Phillip Gross			10.0%	6,012,624
Abeona Therapeutics Inc. 13G/A Amendment 10 ABEO · 00289Y206	ABEO	00289Y206	10.0%	5,352,996	13G/A Amendment 10	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			10.0%	5,352,996
Robert Atchinson			10.0%	5,352,996
Phillip Gross			10.0%	5,352,996
Milestone Pharmaceuticals Inc. 13G MIST · 59935V107	MIST	59935V107	10.0%	8,659,064	13G	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			10.0%	8,659,064
Robert Atchinson			10.0%	8,659,064
Phillip Gross			10.0%	8,659,064
Soleno Therapeutics, Inc. 13G/A Amendment 6 SLNO · 834203309	SLNO	834203309	2.6%	1,401,576	13G/A Amendment 6	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			2.6%	1,401,576
Robert Atchinson			2.6%	1,401,576
Phillip Gross			2.6%	1,401,576
Solid Biosciences Inc. 13G/A Amendment 1 SLDB · 83422E204	SLDB	83422E204	5.1%	4,000,000	13G/A Amendment 1	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			5.1%	4,000,000
Robert Atchinson			5.1%	4,000,000
Phillip Gross			5.1%	4,000,000
Traws Pharma, Inc. 13G/A Amendment 1 TRAW · 68232V884	TRAW	68232V884	4.7%	330,000	13G/A Amendment 1	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			4.7%	330,000
Robert Atchinson			4.7%	330,000
Phillip Gross			4.7%	330,000
EyePoint Pharmaceuticals, Inc. 13G/A Amendment 5 EYPT · 30233G209	EYPT	30233G209	8.1%	5,559,782	13G/A Amendment 5	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			8.1%	5,559,782
Robert Atchinson			8.1%	5,559,782
Phillip Gross			8.1%	5,559,782
Centessa Pharmaceuticals plc 13G/A Amendment 2 CNTA · 152309100	CNTA	152309100	7.5%	10,035,000	13G/A Amendment 2	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			7.5%	10,035,000
Robert Atchinson			7.5%	10,035,000
Phillip Gross			7.5%	10,035,000
Aclaris Therapeutics, Inc. 13G/A Amendment 2 ACRS · 00461U105	ACRS	00461U105	4.9%	5,278,144	13G/A Amendment 2	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			4.9%	5,278,144
Robert Atchinson			4.9%	5,278,144
Phillip Gross			4.9%	5,278,144
Amylyx Pharmaceuticals, Inc. 13G/A Amendment 2 AMLX · 03237H101	AMLX	03237H101	6.4%	6,816,828	13G/A Amendment 2	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			6.4%	6,816,828
Robert Atchinson			6.4%	6,816,828
Phillip Gross			6.4%	6,816,828
MeiraGTx Holdings plc 13G/A Amendment 5 MGTX · G59665102	MGTX	G59665102	5.2%	4,184,578	13G/A Amendment 5	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			5.2%	4,184,578
Robert Atchinson			5.2%	4,184,578
Phillip Gross			5.2%	4,184,578
Adagio Medical Holdings, Inc. 13G/A Amendment 1 ADGM · 00534B100	ADGM	00534B100	6.9%	1,058,501	13G/A Amendment 1	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			6.9%	1,058,501
Robert Atchinson			6.9%	1,058,501
Phillip Gross			6.9%	1,058,501
OTG Acquisition Corp. I 13G OTGAU · G6791A126	OTGAU	G6791A126	7.6%	1,800,000	13G	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			7.6%	1,800,000
Robert Atchinson			7.6%	1,800,000
Phillip Gross			7.6%	1,800,000
Fulcrum Therapeutics, Inc. 13G/A Amendment 2 FULC · 359616109	FULC	359616109	4.5%	2,432,000	13G/A Amendment 2	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			4.5%	2,432,000
Robert Atchinson			4.5%	2,432,000
Phillip Gross			4.5%	2,432,000
Galata Acquisition Corp. II 13G LATAU · G3R25N124	LATAU	G3R25N124	7.8%	1,350,000	13G	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			7.8%	1,350,000
Robert Atchinson			7.8%	1,350,000
Phillip Gross			7.8%	1,350,000
BridgeBio Oncology Therapeutics, Inc. 13G/A Amendment 1 BBOT · 107924102	BBOT	107924102	1.9%	1,487,621	13G/A Amendment 1	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			1.9%	1,487,621
Robert Atchinson			1.9%	1,487,621
Phillip Gross			1.9%	1,487,621
Talon Capital Corp. 13G TLNC · G86652107	TLNC	G86652107	7.9%	2,025,000	13G	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			7.9%	2,025,000
Robert Atchinson			7.9%	2,025,000
Phillip Gross			7.9%	2,025,000
Northpointe Bancshares Inc 13G NPB · 66661N886	NPB	66661N886	5.2%	1,794,104	13G	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			5.2%	1,794,104
Robert Atchinson			5.2%	1,794,104
Phillip Gross			5.2%	1,794,104
Zevra Therapeutics, Inc. 13G/A Amendment 1 ZVRA · 488445206	ZVRA	488445206	4.0%	2,225,000	13G/A Amendment 1	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			4.0%	2,225,000
Robert Atchinson			4.0%	2,225,000
Phillip Gross			4.0%	2,225,000
Monro, Inc. 13G MNRO · 610236101	MNRO	610236101	7.4%	2,222,000	13G	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			7.4%	2,222,000
Robert Atchinson			7.4%	2,222,000
Phillip Gross			7.4%	2,222,000
Highview Merger Corp. 13G HVMC · G4569C101	HVMC	G4569C101	7.6%	1,800,000	13G	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			7.6%	1,800,000
Robert Atchinson			7.6%	1,800,000
Phillip Gross			7.6%	1,800,000
Tango Therapeutics, Inc. 13G/A Amendment 1 TNGX · 87583X109	TNGX	87583X109	2.3%	2,511,000	13G/A Amendment 1	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			2.3%	2,511,000
Robert Atchinson			2.3%	2,511,000
Phillip Gross			2.3%	2,511,000
Bright Minds Biosciences Inc. 13G DRUG · 10919W405	DRUG	10919W405	5.6%	395,743	13G	11/13/2025 Event 9/30/2025
Adage Capital Management, L.P.			5.6%	395,743
Robert Atchinson			5.6%	395,743
Phillip Gross			5.6%	395,743
Praxis Precision Medicines, Inc. 13G/A Amendment 3 PRAX · 74006W207	PRAX	74006W207	5.3%	1,305,175	13G/A Amendment 3	11/3/2025 Event 10/31/2025
Adage Capital Management, L.P.			5.3%	1,305,175
Robert Atchinson			5.3%	1,305,175
Phillip Gross			5.3%	1,305,175
89bio, Inc. 13D/A Amendment 1 ETNB · 282559103	ETNB	282559103	0%	0	13D/A Amendment 1	10/31/2025 Event 10/29/2025
Adage Capital Management, L.P.			0%	0
Robert Atchinson			0%	0
Phillip Gross			0%	0
89bio, Inc. 13D ETNB · 282559103	ETNB	282559103	6.1%	9,097,587	13D	10/3/2025 Event 9/26/2025
Adage Capital Management, L.P.			6.1%	9,097,587
Robert Atchinson			6.1%	9,097,587
Phillip Gross			6.1%	9,097,587
Praxis Precision Medicines, Inc. 13G/A Amendment 2 PRAX · 74006W207	PRAX	74006W207	11.3%	2,374,085	13G/A Amendment 2	9/2/2025 Event 8/31/2025
Adage Capital Management, L.P.			11.3%	2,374,085
Robert Atchinson			11.3%	2,374,085
Phillip Gross			11.3%	2,374,085
EyePoint Pharmaceuticals, Inc. 13G/A Amendment 4 EYPT · 30233G209	EYPT	30233G209	9.9%	6,800,000	13G/A Amendment 4	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			9.9%	6,800,000
Robert Atchinson			9.9%	6,800,000
Phillip Gross			9.9%	6,800,000
TScan Therapeutics, Inc. 13G/A Amendment 3 TCRX · 89854M101	TCRX	89854M101	2.5%	1,350,000	13G/A Amendment 3	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			2.5%	1,350,000
Robert Atchinson			2.5%	1,350,000
Phillip Gross			2.5%	1,350,000
Amylyx Pharmaceuticals, Inc. 13G/A Amendment 1 AMLX · 03237H101	AMLX	03237H101	9.9%	8,800,000	13G/A Amendment 1	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			9.9%	8,800,000
Robert Atchinson			9.9%	8,800,000
Phillip Gross			9.9%	8,800,000
Tango Therapeutics, Inc. 13G TNGX · 87583X109	TNGX	87583X109	5.5%	5,905,349	13G	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			5.5%	5,905,349
Robert Atchinson			5.5%	5,905,349
Phillip Gross			5.5%	5,905,349
DBV Technologies S.A. 13G DBVT · 23306J309	DBVT	23306J309	10.0%	14,614,449	13G	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			10.0%	14,614,449
Robert Atchinson			10.0%	14,614,449
Phillip Gross			10.0%	14,614,449
Adagio Medical Holdings, Inc. 13G ADGM · 00534B100	ADGM	00534B100	5.3%	821,261	13G	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			5.3%	821,261
Robert Atchinson			5.3%	821,261
Phillip Gross			5.3%	821,261
Janux Therapeutics, Inc. 13G/A Amendment 1 JANX · 47103J105	JANX	47103J105	4.3%	2,525,000	13G/A Amendment 1	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			4.3%	2,525,000
Robert Atchinson			4.3%	2,525,000
Phillip Gross			4.3%	2,525,000
Soleno Therapeutics, Inc. 13G/A Amendment 5 SLNO · 834203309	SLNO	834203309	7.1%	3,575,964	13G/A Amendment 5	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			7.1%	3,575,964
Robert Atchinson			7.1%	3,575,964
Phillip Gross			7.1%	3,575,964
Immunic, Inc. 13G/A Amendment 2 IMUX · 4525EP101	IMUX	4525EP101	10.0%	10,479,337	13G/A Amendment 2	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			10.0%	10,479,337
Robert Atchinson			10.0%	10,479,337
Phillip Gross			10.0%	10,479,337
Wave Life Sciences Ltd. 13G/A Amendment 4 WVE · Y95308105	WVE	Y95308105	9.7%	15,016,500	13G/A Amendment 4	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			9.7%	15,016,500
Robert Atchinson			9.7%	15,016,500
Phillip Gross			9.7%	15,016,500
Seadrill Ltd 13G/A Amendment 2 SDRL · G7997W102	SDRL	G7997W102	5.0%	3,138,286	13G/A Amendment 2	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			5.0%	3,138,286
Robert Atchinson			5.0%	3,138,286
Phillip Gross			5.0%	3,138,286
Cabaletta Bio, Inc. 13G/A Amendment 6 CABA · 12674W109	CABA	12674W109	10.0%	9,002,580	13G/A Amendment 6	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			10.0%	9,002,580
Robert Atchinson			10.0%	9,002,580
Phillip Gross			10.0%	9,002,580
ProQR Therapeutics N.V. 13G/A Amendment 2 PRQR · N71542109	PRQR	N71542109	6.3%	6,601,938	13G/A Amendment 2	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			6.3%	6,601,938
Robert Atchinson			6.3%	6,601,938
Phillip Gross			6.3%	6,601,938
Ensysce Biosciences, Inc. 13G/A Amendment 1 ENSC · 293602504	ENSC	293602504	3.2%	74,711	13G/A Amendment 1	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			3.2%	74,711
Robert Atchinson			3.2%	74,711
Phillip Gross			3.2%	74,711
Cidara Therapeutics, Inc. 13G/A Amendment 1 CDTX · 171757206	CDTX	171757206	4.97%	1,100,000	13G/A Amendment 1	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			4.97%	1,100,000
Robert Atchinson			4.97%	1,100,000
Phillip Gross			4.97%	1,100,000
Inozyme Pharma, Inc. 13G/A Amendment 4 INZY · 45790W108	INZY	45790W108	0%	0	13G/A Amendment 4	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			0%	0
Robert Atchinson			0%	0
Phillip Gross			0%	0
Zeo Energy Corp. 13G/A Amendment 1 ZEO · 98944F109	ZEO	98944F109	3.2%	760,000	13G/A Amendment 1	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			3.2%	760,000
Robert Atchinson			3.2%	760,000
Phillip Gross			3.2%	760,000
Praxis Precision Medicines, Inc. 13G/A Amendment 1 PRAX · 74006W207	PRAX	74006W207	9.7%	1,974,585	13G/A Amendment 1	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			9.7%	1,974,585
Robert Atchinson			9.7%	1,974,585
Phillip Gross			9.7%	1,974,585
Centessa Pharmaceuticals plc 13G/A Amendment 1 CNTA · 152309100	CNTA	152309100	6.3%	8,403,000	13G/A Amendment 1	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			6.3%	8,403,000
Robert Atchinson			6.3%	8,403,000
Phillip Gross			6.3%	8,403,000
Fulcrum Therapeutics, Inc. 13G/A Amendment 1 FULC · 359616109	FULC	359616109	8.5%	4,589,000	13G/A Amendment 1	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			8.5%	4,589,000
Robert Atchinson			8.5%	4,589,000
Phillip Gross			8.5%	4,589,000
Aligos Therapeutics, Inc. 13G/A Amendment 2 ALGS · 01626L204	ALGS	01626L204	3.9%	210,000	13G/A Amendment 2	8/12/2025 Event 6/30/2025
Adage Capital Management, L.P.			3.9%	210,000
Robert Atchinson			3.9%	210,000
Phillip Gross			3.9%	210,000
Glycomimetics Inc 13D/A Amendment 1 CBIO · 38000Q201	CBIO	38000Q201	0.4%	50,912	13D/A Amendment 1	6/20/2025 Event 6/20/2025
Adage Capital Management, L.P.			0.4%	50,912
Robert Atchinson			0.4%	50,912
Phillip Gross			0.4%	50,912
Seadrill Ltd 13G/A Amendment 1 SDRL · G7997W102	SDRL	G7997W102	6.8%	4,200,535	13G/A Amendment 1	5/12/2025 Event 3/31/2025
Adage Capital Management, L.P.			6.8%	4,200,535
Robert Atchinson			6.8%	4,200,535
Phillip Gross			6.8%	4,200,535
Aclaris Therapeutics, Inc. 13G/A Amendment 1 ACRS · 00461U105	ACRS	00461U105	7.6%	8,201,344	13G/A Amendment 1	5/12/2025 Event 3/31/2025
Adage Capital Management, L.P.			7.6%	8,201,344
Robert Atchinson			7.6%	8,201,344
Phillip Gross			7.6%	8,201,344
ProQR Therapeutics N.V. 13G/A Amendment 1 PRQR · N71542109	PRQR	N71542109	7.7%	8,102,098	13G/A Amendment 1	5/12/2025 Event 3/31/2025
Adage Capital Management, L.P.			7.7%	8,102,098
Robert Atchinson			7.7%	8,102,098
Phillip Gross			7.7%	8,102,098
Wave Life Sciences Ltd. 13G/A Amendment 3 WVE · Y95308105	WVE	Y95308105	8.2%	12,516,500	13G/A Amendment 3	5/12/2025 Event 3/31/2025
Adage Capital Management, L.P.			8.2%	12,516,500
Robert Atchinson			8.2%	12,516,500
Phillip Gross			8.2%	12,516,500
Soleno Therapeutics, Inc. 13G/A Amendment 4 SLNO · 834203309	SLNO	834203309	9.6%	4,392,696	13G/A Amendment 4	5/12/2025 Event 3/31/2025
Adage Capital Management, L.P.			9.6%	4,392,696
Robert Atchinson			9.6%	4,392,696
Phillip Gross			9.6%	4,392,696
Praxis Precision Medicines, Inc. 13G PRAX · 74006W207	PRAX	74006W207	8.6%	1,742,758	13G	5/12/2025 Event 3/31/2025
Adage Capital Management, L.P.			8.6%	1,742,758
Robert Atchinson			8.6%	1,742,758
Phillip Gross			8.6%	1,742,758
Amylyx Pharmaceuticals, Inc. 13G AMLX · 03237H101	AMLX	03237H101	6.4%	5,697,605	13G	5/12/2025 Event 3/31/2025
Adage Capital Management, L.P.			6.4%	5,697,605
Robert Atchinson			6.4%	5,697,605
Phillip Gross			6.4%	5,697,605
Solid Biosciences Inc. 13G SLDB · 83422E204	SLDB	83422E204	8.7%	6,729,484	13G	5/12/2025 Event 3/31/2025
Adage Capital Management, L.P.			8.7%	6,729,484
Robert Atchinson			8.7%	6,729,484
Phillip Gross			8.7%	6,729,484

Includes filings since 12/18/2024, when the SEC began requiring structured 13D and 13G data.