Investors who own more than 5% of a class must file a Schedule 13D or 13G. Every filing for 86889P208 since 12/18/2024, newest first.
| Filer | % of Class | Filed | |
|---|---|---|---|
|
Boxer Capital Management, LLC
13G/A
Amendment 2
|
11.6% |
10/7/2026
Event 9/30/2026
|
|
| Boxer Capital Management, LLC | 11.6% | ||
| Boxer Holdings, LP | 11.6% | ||
| Boxer Holdings GP, LLC | 11.6% | ||
| Aaron Davis | 11.6% | ||
|
Commodore Capital LP
13G
|
7.5% |
10/1/2026
Event 9/24/2026
|
|
| Commodore Capital LP | 7.5% | ||
| Commodore Capital Master LP | 7.5% | ||
| Robert Egen Atkinson | 7.5% | ||
| Michael Kramarz | 7.5% | ||
|
Boxer Capital Management, LLC
13G/A
Amendment 1
|
8.9% |
8/14/2026
Event 6/30/2026
|
|
| Boxer Capital Management, LLC | 8.9% | ||
| Boxer Holdings, LP | 8.9% | ||
| Boxer Holdings GP, LLC | 8.9% | ||
| Aaron Davis | 8.9% | ||
|
StemPoint Capital LP
13G
|
5.0% |
8/14/2026
Event 6/30/2026
|
|
| StemPoint Capital LP | 5.0% | ||
| StemPoint Capital Management GP LLC | 5.0% | ||
| Michelle Ross | 5.0% | ||
|
Braidwell LP
13G/A
Amendment 1
|
3.9% |
8/14/2026
Event 6/30/2026
|
|
| Braidwell LP | 3.9% | ||
| Braidwell Management LLC | 3.9% | ||
| Alexander T. Karnal | 3.9% | ||
| Brian J. Kreiter | 3.9% | ||
|
5AM Partners VII, LLC
13G/A
Amendment 2
|
7.8% |
8/11/2026
Event 6/30/2026
|
|
| 5AM Partners VII, LLC | 7.8% | ||
| 5AM Ventures VII, L.P. | 7.8% | ||
| Kush Parmar | 7.8% | ||
| Andrew J. Schwab | 7.8% | ||
|
TCG Crossover GP II, LLC
13G/A
Amendment 2
|
9.9% |
7/24/2026
Event 7/22/2026
|
|
| TCG Crossover GP II, LLC | 4.9% | ||
| TCG Crossover Fund II, L.P. | 4.9% | ||
| TCG Crossover GP III, LLC | 4.9% | ||
| TCG Crossover Fund III, L.P. | 4.9% | ||
| Chen Yu | 9.9% | ||
|
Column Group III GP, LP
13D/A
Amendment 6
|
29.3% |
5/18/2026
Event 3/31/2026
|
|
| The Column Group III GP, LP | 23.6% | ||
| The Column Group III, LP | 11.6% | ||
| The Column Group III-A, LP | 13.0% | ||
| The Column Group Opportunity III, LP | 7.2% | ||
| The Column Group Opportunity III GP, LP | 7.2% | ||
| TCG Opportunity III GP, LLC | 7.2% | ||
| Tim Kutzkey | 29.3% | ||
| Peter Svennilson | 29.3% | ||
|
5AM Partners VII, LLC
13G/A
Amendment 1
|
9.5% |
5/15/2026
Event 3/31/2026
|
|
| 5AM Partners VII, LLC | 9.5% | ||
| 5AM Ventures VII, L.P. | 9.5% | ||
| Kush Parmar | 9.5% | ||
| Andrew J. Schwab | 9.5% | ||
|
Venrock Healthcare Capital Partners III, L.P.
13G/A
Amendment 1
|
9.9% |
5/15/2026
Event 3/31/2026
|
|
| Venrock Healthcare Capital Partners III, L.P. | 9.9% | ||
| VHCP Co-Investment Holdings III, LLC | 9.9% | ||
| Venrock Healthcare Capital Partners EG, L.P. | 9.9% | ||
| VHCP Management III, LLC | 9.9% | ||
| VHCP Management EG, LLC | 9.9% | ||
| Nimish Shah | 9.9% | ||
| Bong Y. Koh | 9.9% | ||
|
Boxer Capital Management, LLC
13G
|
6.7% |
5/15/2026
Event 3/31/2026
|
|
| Boxer Capital Management, LLC | 6.7% | ||
| Boxer Holdings, LP | 6.7% | ||
| Boxer Holdings GP, LLC | 6.7% | ||
| Aaron Davis | 6.7% | ||
|
TCG Crossover GP II, LLC
13G/A
Amendment 1
|
12.7% |
5/15/2026
Event 3/31/2026
|
|
| TCG Crossover GP II, LLC | 6.3% | ||
| TCG Crossover Fund II, L.P. | 6.3% | ||
| TCG Crossover GP III, LLC | 6.3% | ||
| TCG Crossover Fund III, L.P. | 6.3% | ||
| Chen Yu | 12.7% | ||
|
Nantahala Capital Management, LLC
13G/A
Amendment 3
|
2.1% |
5/15/2026
Event 3/31/2026
|
|
| Nantahala Capital Management, LLC | 2.1% | ||
| Wilmot B. Harkey | 2.1% | ||
| Daniel Mack | 2.1% | ||
|
StemPoint Capital LP
13G/A
Amendment 5
|
4.5% |
5/15/2026
Event 3/31/2026
|
|
| StemPoint Capital LP | 4.5% | ||
| StemPoint Capital Management GP LLC | 4.5% | ||
| Michelle Ross | 4.5% | ||
|
Point72 Asset Management, L.P.
13G
|
5.4% |
4/23/2026
Event 4/22/2026
|
|
| Point72 Asset Management, L.P. | 5.4% | ||
| Point72 Capital Advisors, Inc. | 5.4% | ||
| Steven A. Cohen | 5.4% | ||
|
RA Capital Management, L.P.
13G/A
Amendment 2
|
9.2% |
2/17/2026
Event 12/31/2025
|
|
| RA Capital Management, L.P. | 9.2% | ||
| Peter Kolchinsky | 9.2% | ||
| Rajeev Shah | 9.2% | ||
| RA Capital Healthcare Fund, L.P. | 9.2% | ||
|
StemPoint Capital LP
13G/A
Amendment 4
|
7.0% |
2/17/2026
Event 12/31/2025
|
|
| StemPoint Capital LP | 7.0% | ||
| StemPoint Capital Management GP LLC | 7.0% | ||
| Michelle Ross | 7.0% | ||
|
Braidwell LP
13G
|
5.5% |
2/17/2026
Event 12/31/2025
|
|
| Braidwell LP | 5.5% | ||
| Braidwell Management LLC | 5.5% | ||
| Alexander T. Karnal | 5.5% | ||
| Brian J. Kreiter | 5.5% | ||
|
Stonepine Capital Management, LLC
13G/A
Amendment 4
|
3.6% |
2/13/2026
Event 12/31/2025
|
|
| Stonepine Capital Management, LLC | 3.6% | ||
| Stonepine Capital, L.P. | 3.6% | ||
| Stonepine GP, LLC | 3.6% | ||
| Jon M. Plexico | 3.6% | ||
|
Column Group IV GP, LP
13D
|
11.6% |
2/12/2026
Event 2/6/2026
|
|
| The Column Group IV GP, LP | 8.3% | ||
| The Column Group IV, LP | 8.0% | ||
| The Column Group IV-A, LP | 0.3% | ||
| The Column Group Opportunity III, LP | 3.5% | ||
| The Column Group Opportunity III GP, LP | 3.5% | ||
| TCG Opportunity III GP, LLC | 3.5% | ||
| Tim Kutzkey | 11.6% | ||
| Peter Svennilson | 11.6% | ||
|
Integrated Core Strategies (US) LLC
13G/A
Amendment 1
|
8.5% |
2/5/2026
Event 12/31/2025
|
|
| Integrated Core Strategies (US) LLC | 8.4% | ||
| Millennium Management LLC | 8.5% | ||
| Millennium Group Management LLC | 8.5% | ||
| Israel A. Englander | 8.5% | ||
|
TCG Crossover GP II, LLC
13G
|
11.4% |
2/2/2026
Event 1/26/2026
|
|
| TCG Crossover GP II, LLC | 5.7% | ||
| TCG Crossover Fund II, L.P. | 5.7% | ||
| TCG Crossover GP III, LLC | 5.7% | ||
| TCG Crossover Fund III, L.P. | 5.7% | ||
| Chen Yu | 11.4% | ||
|
Column Group III GP, LP
13D/A
Amendment 5
|
35.1% |
1/22/2026
Event 1/20/2026
|
|
| The Column Group III GP, LP | 28.6% | ||
| The Column Group III, LP | 14.2% | ||
| The Column Group III-A, LP | 15.9% | ||
| The Column Group Opportunity III, LP | 8.8% | ||
| The Column Group Opportunity III GP, LP | 8.8% | ||
| TCG Opportunity III GP, LLC | 8.8% | ||
| Tim Kutzkey | 35.1% | ||
| Peter Svennilson | 35.1% | ||
|
Integrated Core Strategies (US) LLC
13G
|
6.6% |
11/20/2025
Event 11/13/2025
|
|
| Integrated Core Strategies (US) LLC | 6.5% | ||
| Millennium Management LLC | 6.6% | ||
| Millennium Group Management LLC | 6.6% | ||
| Israel A. Englander | 6.6% | ||
|
Nantahala Capital Management, LLC
13G/A
Amendment 2
|
5.2% |
8/14/2025
Event 6/30/2025
|
|
| Nantahala Capital Management, LLC | 5.2% | ||
| Wilmot B. Harkey | 5.2% | ||
| Daniel Mack | 5.2% | ||
|
StemPoint Capital LP
13G/A
Amendment 3
|
11.4% |
8/14/2025
Event 6/30/2025
|
|
| StemPoint Capital LP | 11.4% | ||
| StemPoint Capital Management GP LLC | 11.4% | ||
| Michelle Ross | 11.4% | ||
| Driehaus Capital Management LLC 13G/A Amendment 1 | 0.8% |
8/14/2025
Event 6/30/2025
|
|
|
Stonepine Capital Management, LLC
13G/A
Amendment 3
|
5.8% |
8/13/2025
Event 6/30/2025
|
|
| Stonepine Capital Management, LLC | 5.8% | ||
| Stonepine Capital, L.P. | 5.8% | ||
| Stonepine GP, LLC | 5.8% | ||
| Jon M. Plexico | 5.8% | ||
|
RA Capital Management, L.P.
13G/A
Amendment 1
|
9.9% |
5/15/2025
Event 3/31/2025
|
|
| RA Capital Management, L.P. | 9.9% | ||
| Peter Kolchinsky | 9.9% | ||
| Rajeev Shah | 9.9% | ||
| RA Capital Healthcare Fund, L.P. | 9.9% | ||
| Nantahala Capital Partners Limited Partnership 13G/A Amendment 1 | 2.2% |
5/15/2025
Event 3/31/2025
|
|
|
StemPoint Capital LP
13G/A
Amendment 2
|
15.8% |
5/15/2025
Event 3/31/2025
|
|
| StemPoint Capital LP | 15.8% | ||
| StemPoint Capital Management GP LLC | 15.8% | ||
| Michelle Ross | 15.8% | ||
|
Perceptive Advisors LLC
13G/A
Amendment 1
|
1.9% |
5/15/2025
Event 3/31/2025
|
|
| Perceptive Advisors LLC | 1.9% | ||
| Joseph Edelman | 1.9% | ||
| Perceptive Life Sciences Master Fund, Ltd. | 1.9% | ||
| Driehaus Capital Management LLC 13G | 6.3% |
5/15/2025
Event 3/31/2025
|
|
|
Stonepine Capital Management, LLC
13G/A
Amendment 2
|
9.9% |
5/14/2025
Event 3/31/2025
|
|
| Stonepine Capital Management, LLC | 9.9% | ||
| Stonepine Capital, L.P. | 9.9% | ||
| Stonepine GP, LLC | 9.9% | ||
| Jon M. Plexico | 9.9% | ||
|
Venrock Healthcare Capital Partners III, L.P.
13G
|
9.9% |
4/2/2025
Event 3/26/2025
|
|
| Venrock Healthcare Capital Partners III, L.P. | 9.9% | ||
| VHCP Co-Investment Holdings III, LLC | 9.9% | ||
| Venrock Healthcare Capital Partners EG, L.P. | 9.9% | ||
| VHCP Management III, LLC | 9.9% | ||
| VHCP Management EG, LLC | 9.9% | ||
| Nimish Shah | 9.9% | ||
| Bong Y Koh | 9.9% | ||
|
5AM Partners VII, LLC
13G
|
9.9% |
4/2/2025
Event 3/26/2025
|
|
| 5AM Partners VII, LLC | 9.9% | ||
| 5AM Ventures VII, L.P. | 9.9% | ||
| Kush Parmar | 9.9% | ||
| Andrew J. Schwab | 9.9% | ||
|
AI Biotechnology LLC
13G
|
9.9% |
3/31/2025
Event 3/24/2025
|
|
| AI Biotechnology LLC | 9.9% | ||
| Access Industries Holdings LLC | 9.9% | ||
| Access Industries Management, LLC | 9.9% | ||
| Len Blavatnik | 9.9% | ||
|
Column Group III GP, LP
13D/A
Amendment 4
|
34.0% |
3/28/2025
Event 3/26/2025
|
|
| The Column Group III GP, LP | 26.8% | ||
| The Column Group III, LP | 13.3% | ||
| The Column Group III-A, LP | 15.0% | ||
| The Column Group Opportunity III, LP | 9.6% | ||
| The Column Group Opportunity III GP, LP | 9.6% | ||
| TCG Opportunity III GP, LLC | 9.6% | ||
| Tim Kutzkey | 34.0% | ||
|
Alyeska Investment Group, L.P.
13G/A
Amendment 2
|
0.8% |
2/14/2025
Event 12/31/2024
|
|
| Alyeska Investment Group, L.P. | 0.8% | ||
| Alyeska Fund GP, LLC | 0.8% | ||
| Anand Parekh | 0.8% | ||
|
Nantahala Capital Management, LLC
13G/A
Amendment 1
|
10.0% |
2/14/2025
Event 12/31/2024
|
|
| Nantahala Capital Management, LLC | 10.0% | ||
| Wilmot B. Harkey | 10.0% | ||
| Daniel Mack | 10.0% | ||
|
StemPoint Capital LP
13G/A
Amendment 1
|
14.3% |
2/14/2025
Event 12/31/2024
|
|
| StemPoint Capital LP | 14.3% | ||
| StemPoint Capital Management GP LLC | 14.3% | ||
| Michelle Ross | 14.3% | ||
|
Perceptive Advisors LLC
13G
|
5.1% |
2/14/2025
Event 12/31/2024
|
|
| Perceptive Advisors LLC | 5.1% | ||
| Joseph Edelman | 5.1% | ||
| Perceptive Life Sciences Master Fund, Ltd. | 5.1% | ||
| Regents of the University of California 13G | 4.2% |
1/28/2025
Event 12/31/2024
|
|
| Nantahala Capital Partners Limited Partnership 13G | 5.3% |
11/14/2024
Event 9/30/2024
|
|
|
Nantahala Capital Management, LLC
13G
|
10.0% |
11/14/2024
Event 9/30/2024
|
|
| Nantahala Capital Management, LLC | 10.0% | ||
| Wilmot B. Harkey | 10.0% | ||
| Daniel Mack | 10.0% |
| Period | Filings | Shares, Excl. Options | Value, Excl. Options |
|---|---|---|---|
| 2026 Q3 | 1 | 62.0 | $2.00 k |
| 2026 Q2 | 71 | 10.7 M | $275 M |
| 2026 Q1 | 60 | 9.51 M | $275 M |
| 2025 Q4 | 55 | 7.27 M | $156 M |
| 2025 Q3 | 36 | 4.98 M | $64.1 M |
| 2025 Q2 | 32 | 4.66 M | $41.7 M |
| 2025 Q1 | 30 | 3.95 M | $46.0 M |
| 2024 Q4 | 24 | 1.66 M | $23.8 M |
| 2024 Q3 | 24 | 1.32 M | $15.8 M |
| 2024 Q2 | 25 | 1.52 M | $16.6 M |
| 2024 Q1 | 19 | 411 k | $6.42 M |
| 2023 Q4 | 20 | 448 k | $4.21 M |