Investors who own more than 5% of a class must file a Schedule 13D or 13G. Every filing for 88032L605 since 12/18/2024, newest first.
| Filer | % of Class | Filed | |
|---|---|---|---|
|
Dellora Investments LP
13G/A
Amendment 5
|
6.4% |
10/9/2026
Event 10/2/2026
|
|
| Dellora Investments Master Fund LP | 5.5% | ||
| Dellora Investments LP | 6.4% | ||
| Kevin Pyun | 6.4% | ||
|
ING Groep N.V.
13G/A
Amendment 1
|
0% |
9/11/2026
Event 9/3/2026
|
|
| ING Groep N.V. | 0% | ||
| ING Capital Markets LLC | 0% | ||
|
ADAR1 Capital Management, LLC
13G
|
14.0% |
9/8/2026
Event 8/31/2026
|
|
| ADAR1 Capital Management, LLC | 14.0% | ||
| Daniel Schneeberger | 14.0% | ||
|
FMR LLC
13G/A
Amendment 1
|
1.4% |
9/8/2026
Event 8/31/2026
|
|
| FMR LLC | 1.4% | ||
| Abigail P. Johnson | 1.4% | ||
|
Sphera Funds Management Ltd.
13G
|
5.3% |
8/27/2026
Event 8/17/2026
|
|
| Sphera Funds Management Ltd. | 5.3% | ||
| Sphera Global Healthcare GP Ltd. | 5.3% | ||
| Sphera Global Healthcare Management LP | 5.3% | ||
|
ING Groep N.V.
13G
|
7.1% |
8/27/2026
Event 8/19/2026
|
|
| ING Groep N.V. | 7.1% | ||
| ING Capital Markets LLC | 7.1% | ||
|
Millennium Management LLC
13G
|
5.8% |
8/18/2026
Event 8/13/2026
|
|
| Millennium Management LLC | 5.8% | ||
| Millennium Group Management LLC | 5.8% | ||
| Israel A. Englander | 5.8% | ||
|
RTW Investments, LP
13G/A
Amendment 3
|
9.9% |
8/14/2026
Event 6/30/2026
|
|
| RTW Investments, LP | 9.9% | ||
| Roderick Wong | 9.9% | ||
|
Venrock Healthcare Capital Partners III, L.P.
13G/A
Amendment 6
|
4.7% |
8/14/2026
Event 6/30/2026
|
|
| Venrock Healthcare Capital Partners III, L.P. | 4.7% | ||
| VHCP Co-Investment Holdings III, LLC | 4.7% | ||
| Venrock Healthcare Capital Partners EG, L.P. | 4.7% | ||
| VHCP Management III, LLC | 4.7% | ||
| VHCP Management EG, LLC | 4.7% | ||
| Nimish Shah | 4.7% | ||
| Bong Y. Koh | 4.7% | ||
|
Vivo Opportunity Fund Holdings, L.P.
13G/A
Amendment 1
|
9.0% |
8/14/2026
Event 6/30/2026
|
|
| Vivo Opportunity Fund Holdings, L.P. | 9.0% | ||
| Vivo Opportunity, LLC | 9.0% | ||
|
Ikarian Capital, LLC
13G/A
Amendment 3
|
2.9% |
8/14/2026
Event 6/30/2026
|
|
| Ikarian Capital, LLC | 2.9% | ||
| Neil Shahrestani | 2.9% | ||
|
Perceptive Advisors LLC
13G/A
Amendment 3
|
4.5% |
8/14/2026
Event 6/30/2026
|
|
| Perceptive Advisors LLC | 4.5% | ||
| Joseph Edelman | 4.5% | ||
| Perceptive Life Sciences Master Fund, Ltd. | 4.5% | ||
|
Biotechnology Value Fund L P
13G/A
Amendment 3
|
10.0% |
8/14/2026
Event 6/30/2026
|
|
| Biotechnology Value Fund L P | 9.5% | ||
| BVF I GP LLC | 9.5% | ||
| Biotechnology Value Fund II LP | 0.5% | ||
| BVF II GP LLC | 0.5% | ||
| Biotechnology Value Trading Fund OS LP | 0% | ||
| BVF Partners OS Ltd. | 0% | ||
| BVF GP Holdings LLC | 10.0% | ||
| BVF Partners L P/IL | 10.0% | ||
| BVF Inc/IL | 10.0% | ||
| Lampert Mark N | 10.0% | ||
|
Adage Capital Management, L.P.
13G/A
Amendment 1
|
6.8% |
8/12/2026
Event 6/30/2026
|
|
| Adage Capital Management, L.P. | 6.8% | ||
| Robert Atchinson | 6.8% | ||
| Phillip Gross | 6.8% | ||
| Christopher Thomas Giordano 13D/A Amendment 1 | 4.3% |
7/31/2026
Event 7/31/2026
|
|
| BlackRock, Inc. 13G | 6.4% |
7/30/2026
Event 6/30/2026
|
|
|
Millennium Management LLC
13G/A
Amendment 1
|
3.3% |
7/17/2026
Event 6/30/2026
|
|
| Millennium Management LLC | 3.3% | ||
| Millennium Group Management LLC | 3.3% | ||
| Israel A. Englander | 3.3% | ||
|
FMR LLC
13G
|
14.9% |
7/8/2026
Event 6/30/2026
|
|
| FMR LLC | 14.9% | ||
| Abigail P. Johnson | 14.9% | ||
| Price T Rowe Associates Inc /MD/ 13G/A Amendment 3 | 2.2% |
6/5/2026
Event 5/31/2026
|
|
|
Millennium Management LLC
13G
|
5.1% |
5/20/2026
Event 5/18/2026
|
|
| Millennium Management LLC | 5.1% | ||
| Millennium Group Management LLC | 5.1% | ||
| Israel A. Englander | 5.1% | ||
|
Dellora Investments LP
13G/A
Amendment 4
|
2.3% |
5/15/2026
Event 3/31/2026
|
|
| Dellora Investments Master Fund LP | 2.0% | ||
| Dellora Investments LP | 2.3% | ||
| Kevin Pyun | 2.3% | ||
|
Venrock Healthcare Capital Partners III, L.P.
13G/A
Amendment 5
|
9.9% |
5/15/2026
Event 3/31/2026
|
|
| Venrock Healthcare Capital Partners III, L.P. | 9.9% | ||
| VHCP Co-Investment Holdings III, LLC | 9.9% | ||
| Venrock Healthcare Capital Partners EG, L.P. | 9.9% | ||
| VHCP Management III, LLC | 9.9% | ||
| VHCP Management EG, LLC | 9.9% | ||
| Nimish Shah | 9.9% | ||
| Bong Y. Koh | 9.9% | ||
|
RTW Investments, LP
13G/A
Amendment 2
|
9.9% |
5/15/2026
Event 3/31/2026
|
|
| RTW Investments, LP | 9.9% | ||
| Roderick Wong | 9.9% | ||
|
Perceptive Advisors LLC
13G/A
Amendment 2
|
5.5% |
5/15/2026
Event 3/31/2026
|
|
| Perceptive Advisors LLC | 5.5% | ||
| Joseph Edelman | 5.5% | ||
| Perceptive Life Sciences Master Fund, Ltd. | 5.5% | ||
|
Logos Global Management LP
13G/A
Amendment 1
|
3.0% |
5/15/2026
Event 3/31/2026
|
|
| Logos Global Management LP | 3.0% | ||
| Logos Global Management GP LLC | 3.0% | ||
| Logos Global Master Fund LP | 3.0% | ||
| Logos GP LLC | 3.0% | ||
| Arsani William | 3.0% | ||
|
Stonepine Capital Management, LLC
13G/A
Amendment 2
|
3.7% |
5/15/2026
Event 3/31/2026
|
|
| Stonepine Capital Management, LLC | 3.7% | ||
| Stonepine Capital, L.P. | 3.7% | ||
| Stonepine GP, LLC | 3.7% | ||
| Jon M. Plexico | 3.7% | ||
|
Lind Global Fund II LP
13G/A
Amendment 4
|
0.8% |
5/15/2026
Event 3/31/2026
|
|
| Lind Global Fund II LP | 0.8% | ||
| Lind Global Partners II LLC | 0.8% | ||
| Easton Jeff | 0.8% | ||
|
Biotechnology Value Fund L P
13G/A
Amendment 2
|
10.0% |
5/15/2026
Event 3/31/2026
|
|
| Biotechnology Value Fund L P | 9.2% | ||
| BVF I GP LLC | 9.2% | ||
| Biotechnology Value Fund II LP | 0.9% | ||
| BVF II GP LLC | 0.9% | ||
| Biotechnology Value Trading Fund OS LP | 0% | ||
| BVF Partners OS Ltd. | 0% | ||
| BVF GP Holdings LLC | 10.0% | ||
| BVF Partners L P/IL | 10.0% | ||
| BVF Inc/IL | 10.0% | ||
| Lampert Mark N | 10.0% | ||
|
Point72 Asset Management, L.P.
13G/A
Amendment 2
|
3.1% |
5/15/2026
Event 3/31/2026
|
|
| Point72 Asset Management, L.P. | 3.1% | ||
| Point72 Capital Advisors, Inc. | 3.1% | ||
| Steven A. Cohen | 3.1% | ||
|
Integrated Core Strategies (US) LLC
13G/A
Amendment 2
|
2.1% |
5/8/2026
Event 3/31/2026
|
|
| Integrated Core Strategies (US) LLC | 1.7% | ||
| Millennium Management LLC | 2.1% | ||
| Millennium Group Management LLC | 2.1% | ||
| Israel A. Englander | 2.1% | ||
| Price T Rowe Associates Inc /MD/ 13G/A Amendment 2 | 11.0% |
5/7/2026
Event 4/30/2026
|
|
| Price T Rowe Associates Inc /MD/ 13G/A Amendment 1 | 17.2% |
5/7/2026
Event 3/31/2026
|
|
|
Invus Global Management, LLC
13G/A
Amendment 1
|
2.5% |
5/4/2026
Event 3/31/2026
|
|
| Invus Public Equities, L.P. | 2.1% | ||
| Invus Public Equities Advisors, LLC | 2.1% | ||
| Invus Global Management, LLC | 2.1% | ||
| Siren, L.L.C. | 2.1% | ||
| Avicenna Life Sci Master Fund LP | 0.4% | ||
| Avicenna Life Sci Master GP LLC | 0.4% | ||
| Ulys, L.L.C. | 0.4% | ||
| Raymond Debbane | 2.5% | ||
|
Morgan Stanley
13G/A
Amendment 1
|
3.5% |
4/8/2026
Event 3/31/2026
|
|
| Morgan Stanley | 3.5% | ||
| Morgan Stanley Capital Services LLC | 3.4% | ||
|
Ikarian Capital, LLC
13G/A
Amendment 2
|
6.7% |
4/7/2026
Event 3/31/2026
|
|
| Ikarian Capital, LLC | 6.7% | ||
| Neil Shahrestani | 6.7% | ||
| Christopher Thomas Giordano 13D | 6.8% |
3/10/2026
Event 12/10/2025
|
|
|
Logos Global Management LP
13G
|
9.9% |
3/9/2026
Event 2/27/2026
|
|
| Logos Global Management LP | 9.9% | ||
| Logos Global Management GP LLC | 9.9% | ||
| Logos Global Master Fund LP | 9.9% | ||
| Logos GP LLC | 9.9% | ||
| Arsani William | 9.9% | ||
|
Dellora Investments LP
13G/A
Amendment 3
|
6.4% |
2/17/2026
Event 12/31/2025
|
|
| Dellora Investments Master Fund LP | 5.7% | ||
| Dellora Investments LP | 6.4% | ||
| Kevin Pyun | 6.4% | ||
|
Venrock Healthcare Capital Partners III, L.P.
13G/A
Amendment 4
|
9.9% |
2/17/2026
Event 12/31/2025
|
|
| Venrock Healthcare Capital Partners III, L.P. | 9.9% | ||
| VHCP Co-Investment Holdings III, LLC | 9.9% | ||
| Venrock Healthcare Capital Partners EG, L.P. | 9.9% | ||
| VHCP Management III, LLC | 9.9% | ||
| VHCP Management EG, LLC | 9.9% | ||
| Nimish Shah | 9.9% | ||
| Bong Y. Koh | 9.9% | ||
|
RTW Investments, LP
13G/A
Amendment 1
|
9.9% |
2/17/2026
Event 12/31/2025
|
|
| RTW Investments, LP | 9.9% | ||
| Roderick Wong | 9.9% | ||
|
Perceptive Advisors LLC
13G/A
Amendment 1
|
9.1% |
2/17/2026
Event 12/31/2025
|
|
| Perceptive Advisors LLC | 9.1% | ||
| Joseph Edelman | 9.1% | ||
| Perceptive Life Sciences Master Fund, Ltd. | 9.1% | ||
|
Lind Global Fund II LP
13G/A
Amendment 3
|
6.6% |
2/17/2026
Event 12/31/2025
|
|
| Lind Global Fund II LP | 6.6% | ||
| Lind Global Partners II LLC | 6.6% | ||
| Easton Jeff | 6.6% | ||
|
Biotechnology Value Fund L P
13G/A
Amendment 1
|
10.0% |
2/17/2026
Event 12/31/2025
|
|
| Biotechnology Value Fund L P | 7.8% | ||
| BVF I GP LLC | 7.8% | ||
| Biotechnology Value Fund II LP | 2.3% | ||
| BVF II GP LLC | 2.3% | ||
| Biotechnology Value Trading Fund OS LP | 0% | ||
| BVF Partners OS Ltd. | 0% | ||
| BVF GP Holdings LLC | 9.9% | ||
| BVF Partners L P/IL | 10.0% | ||
| BVF Inc/IL | 10.0% | ||
| Lampert Mark N | 10.0% | ||
|
Point72 Asset Management, L.P.
13G/A
Amendment 1
|
6.8% |
2/17/2026
Event 12/31/2025
|
|
| Point72 Asset Management, L.P. | 6.8% | ||
| Point72 Capital Advisors, Inc. | 6.8% | ||
| Steven A. Cohen | 6.8% | ||
|
Morgan Stanley
13G
|
9.6% |
2/12/2026
Event 12/31/2025
|
|
| Morgan Stanley | 9.6% | ||
| Morgan Stanley Capital Services LLC | 9.5% | ||
|
Perceptive Advisors LLC
13G
|
7.0% |
12/23/2025
Event 12/18/2025
|
|
| Perceptive Advisors LLC | 7.0% | ||
| Joseph Edelman | 7.0% | ||
| Perceptive Life Sciences Master Fund, Ltd. | 7.0% | ||
| Janus Henderson Group PLC 13G | 10.0% |
12/8/2025
Event 11/28/2025
|
|
|
Ikarian Capital, LLC
13G/A
Amendment 1
|
15.5% |
12/5/2025
Event 11/30/2025
|
|
| Ikarian Capital, LLC | 15.5% | ||
| Neil Shahrestani | 15.5% | ||
|
Venrock Healthcare Capital Partners III, L.P.
13G/A
Amendment 3
|
9.9% |
11/14/2025
Event 9/30/2025
|
|
| Venrock Healthcare Capital Partners III, L.P. | 9.9% | ||
| VHCP Co-Investment Holdings III, LLC | 9.9% | ||
| Venrock Healthcare Capital Partners EG, L.P. | 9.9% | ||
| VHCP Management III, LLC | 9.9% | ||
| VHCP Management EG, LLC | 9.9% | ||
| Nimish Shah | 9.9% | ||
| Bong Y. Koh | 9.9% | ||
|
Lind Global Fund II LP
13G/A
Amendment 2
|
8.8% |
11/14/2025
Event 9/30/2025
|
|
| Lind Global Fund II LP | 8.8% | ||
| Lind Global Partners II LLC | 8.8% | ||
| Easton Jeff | 8.8% | ||
|
Vestal Point Capital, LP
13G
|
9.9% |
11/14/2025
Event 9/30/2024
|
|
| Vestal Point Capital, LP | 9.9% | ||
| Ryan Wilder | 9.9% | ||
|
Integrated Core Strategies (US) LLC
13G/A
Amendment 1
|
6.9% |
11/5/2025
Event 9/30/2025
|
|
| Integrated Core Strategies (US) LLC | 6.9% | ||
| Millennium Management LLC | 6.9% | ||
| Millennium Group Management LLC | 6.9% | ||
| Israel A. Englander | 6.9% | ||
|
Point72 Asset Management, L.P.
13G
|
7.4% |
10/29/2025
Event 10/22/2025
|
|
| Point72 Asset Management, L.P. | 7.4% | ||
| Point72 Capital Advisors, Inc. | 7.4% | ||
| Steven A. Cohen | 7.4% | ||
|
Ikarian Capital, LLC
13G
|
21.2% |
10/7/2025
Event 9/30/2025
|
|
| Ikarian Capital, LLC | 21.2% | ||
| Neil Shahrestani | 21.2% | ||
|
Invus Global Management, LLC
13G
|
9.4% |
10/2/2025
Event 9/26/2025
|
|
| Invus Public Equities, L.P. | 8.0% | ||
| Invus Public Equities Advisors, LLC | 8.0% | ||
| Invus Global Management, LLC | 8.0% | ||
| Siren, L.L.C. | 8.0% | ||
| Avicenna Life Sci Master Fund LP | 1.3% | ||
| Avicenna Life Sci Master GP LLC | 1.3% | ||
| Ulys, L.L.C. | 1.3% | ||
| Raymond Debbane | 9.4% | ||
| Janus Henderson Group PLC 13G/A Amendment 4 | 4.0% |
8/14/2025
Event 6/30/2025
|
|
|
Integrated Core Strategies (US) LLC
13G
|
5.6% |
6/30/2025
Event 6/26/2025
|
|
| Integrated Core Strategies (US) LLC | 5.6% | ||
| Millennium Management LLC | 5.6% | ||
| Millennium Group Management LLC | 5.6% | ||
| Israel A. Englander | 5.6% | ||
|
RTW Investments, LP
13G
|
10.0% |
5/15/2025
Event 3/31/2025
|
|
| RTW Investments, LP | 10.0% | ||
| Roderick Wong, M.D. | 10.0% | ||
|
Janus Henderson Group PLC
13G/A
Amendment 3
|
9.9% |
5/14/2025
Event 3/31/2025
|
|
| Janus Henderson Group PLC | 9.9% | ||
| Janus Henderson Biotech Innovation Master Fund Ltd | 9.9% | ||
|
Dellora Investments LP
13G/A
Amendment 2
|
8.8% |
4/4/2025
Event 3/5/2025
|
|
| Dellora Investments Master Fund LP | 7.7% | ||
| Dellora Investments LP | 8.8% | ||
| Kevin Pyun | 8.8% | ||
| S.H.N. Financial Investments Ltd. 13G/A Amendment 1 | 4.99% |
3/18/2025
Event 12/31/2024
|
|
| Janus Henderson Group PLC 13G/A Amendment 2 | 5.4% |
2/14/2025
Event 12/31/2024
|
|
|
Dellora Investments LP
13G/A
Amendment 1
|
10.3% |
1/15/2025
Event 1/8/2025
|
|
| Dellora Investments Master Fund LP | 9.0% | ||
| Dellora Investments LP | 10.3% | ||
| Kevin Pyun | 10.3% | ||
|
Dellora Investments LP
13G
|
6.9% |
12/5/2024
Event 11/27/2024
|
|
| Dellora Investments Master Fund LP | 5.9% | ||
| Dellora Investments LP | 6.9% | ||
| Kevin Pyun | 6.9% |
| Period | Filings | Shares, Excl. Options | Value, Excl. Options |
|---|---|---|---|
| 2026 Q3 | 1 | 2.59 k | $4.90 k |
| 2026 Q2 | 129 | 30.3 M | $442 M |
| 2026 Q1 | 85 | 21.8 M | $348 M |
| 2025 Q4 | 50 | 7.06 M | $86.1 M |
| 2025 Q3 | 34 | 4.72 M | $35.9 M |
| 2025 Q2 | 27 | 2.23 M | $12.9 M |
| 2025 Q1 | 24 | 2.01 M | $13.1 M |
| 2024 Q4 | 22 | 1.36 M | $8.43 M |
| 2024 Q3 | 20 | 1.23 M | $4.25 M |
| 2024 Q2 | 13 | 19.1 k | $58.0 k |
| 2024 Q1 | 12 | 7.76 k | $32.7 k |