Investors who own more than 5% of a class must file a Schedule 13D or 13G. Every filing for 86150R107 since 12/18/2024, newest first.
| Filer | % of Class | Filed | |
|---|---|---|---|
|
Biotechnology Value Fund L P
13G
|
5.6% |
9/30/2026
Event 9/23/2026
|
|
| Biotechnology Value Fund L P | 2.9% | ||
| BVF I GP LLC | 2.9% | ||
| Biotechnology Value Fund II LP | 2.2% | ||
| BVF II GP LLC | 2.2% | ||
| Biotechnology Value Trading Fund OS LP | 0.4% | ||
| BVF Partners OS Ltd. | 0.4% | ||
| BVF GP Holdings LLC | 5.1% | ||
| BVF Partners L P/IL | 5.6% | ||
| BVF Inc/IL | 5.6% | ||
| Lampert Mark N | 5.6% | ||
|
Lynx1 Capital Management LP
13G/A
Amendment 5
|
6.5% |
8/14/2026
Event 6/30/2026
|
|
| Lynx1 Capital Management LP | 6.5% | ||
| Weston Nichols | 6.5% | ||
|
Toronto Dominion Bank
13G/A
Amendment 2
|
4.9% |
8/12/2026
Event 6/30/2026
|
|
| The Toronto-Dominion Bank | 4.9% | ||
| TD Securities Inc. | 0% | ||
|
FMR LLC
13G/A
Amendment 4
|
8.5% |
8/6/2026
Event 6/30/2026
|
|
| FMR LLC | 8.5% | ||
| Abigail P. Johnson | 8.5% | ||
|
Lynx1 Capital Management LP
13G/A
Amendment 4
|
8.1% |
5/18/2026
Event 3/31/2026
|
|
| Lynx1 Capital Management LP | 8.1% | ||
| Weston Nichols | 8.1% | ||
|
RTW Investments, LP
13G/A
Amendment 7
|
9.9% |
5/15/2026
Event 3/31/2026
|
|
| RTW Investments, LP | 9.9% | ||
| Roderick Wong | 9.9% | ||
|
Redmile Group, LLC
13G/A
Amendment 6
|
6.7% |
5/15/2026
Event 3/31/2026
|
|
| Redmile Group, LLC | 6.7% | ||
| Jeremy C. Green | 6.7% | ||
| Redmile Biopharma Investments III, L.P. | 5.6% | ||
|
Toronto Dominion Bank
13G/A
Amendment 1
|
5.4% |
5/15/2026
Event 3/31/2026
|
|
| The Toronto-Dominion Bank | 5.4% | ||
| TD Securities Inc. | 0% | ||
|
Lynx1 Capital Management LP
13G/A
Amendment 3
|
7.0% |
5/15/2026
Event 3/31/2026
|
|
| Lynx1 Capital Management LP | 7.0% | ||
| Weston Nichols | 7.0% | ||
|
Wellington Management Group LLP
13G
|
5.2% |
5/15/2026
Event 3/31/2026
|
|
| Wellington Management Group LLP | 5.2% | ||
| Wellington Group Holdings LLP | 5.2% | ||
| Wellington Investment Advisors Holdings LLP | 5.2% | ||
| Wellington Management Company LLP | 5.1% | ||
| Vanguard Group Inc 13G/A Amendment 2 | 0% |
3/27/2026
Event 3/13/2026
|
|
|
Baker Bros. Advisors LP
13G/A
Amendment 1
|
5.8% |
2/17/2026
Event 12/31/2025
|
|
| Baker Bros. Advisors LP | 5.8% | ||
| Baker Bros. Advisors (GP) LLC | 5.8% | ||
| Julian C. Baker | 5.8% | ||
| Felix J. Baker | 5.8% | ||
|
FMR LLC
13G/A
Amendment 3
|
9.8% |
2/5/2026
Event 12/31/2025
|
|
| FMR LLC | 9.8% | ||
| Abigail P. Johnson | 9.8% | ||
| Cowen Financial Products LLC 13G/A Amendment 2 | 0% |
11/14/2025
Event 9/30/2025
|
|
| Toronto Dominion Bank 13G | 5.8% |
11/14/2025
Event 9/30/2025
|
|
|
FMR LLC
13G/A
Amendment 2
|
12.5% |
11/5/2025
Event 9/30/2025
|
|
| FMR LLC | 12.5% | ||
| Abigail P. Johnson | 12.5% | ||
| BlackRock, Inc. 13G/A Amendment 2 | 6.8% |
10/17/2025
Event 9/30/2025
|
|
|
Skorpios Trust
13D/A
Amendment 6
|
4.1% |
8/26/2025
Event 8/22/2025
|
|
| Blue Horizon Enterprise Ltd | 3.6% | ||
| Ezbon International Ltd | 0.5% | ||
| Montrago Trustees Ltd | 4.1% | ||
| Skorpios Trust | 4.1% | ||
|
Redmile Group, LLC
13G/A
Amendment 5
|
8.0% |
8/14/2025
Event 6/30/2025
|
|
| Redmile Group, LLC | 8.0% | ||
| Jeremy C. Green | 8.0% | ||
| Redmile Biopharma Investments III, L.P. | 6.4% | ||
|
FMR LLC
13G/A
Amendment 1
|
13.6% |
8/6/2025
Event 6/30/2025
|
|
| FMR LLC | 13.6% | ||
| Abigail P. Johnson | 13.6% | ||
| Cowen Financial Products LLC 13G/A Amendment 1 | 5.8% |
7/29/2025
Event 6/30/2025
|
|
| BlackRock Portfolio Management LLC 13G/A Amendment 1 | 4.7% |
7/15/2025
Event 6/30/2025
|
|
|
Skorpios Trust
13D/A
Amendment 5
|
6.0% |
6/23/2025
Event 6/18/2025
|
|
| Blue Horizon Enterprise Ltd | 5.4% | ||
| Ezbon International Ltd | 0.5% | ||
| Montrago Trustees Ltd | 6.0% | ||
| Skorpios Trust | 6.0% | ||
|
Skorpios Trust
13D/A
Amendment 4
|
7.2% |
6/6/2025
Event 6/4/2025
|
|
| Blue Horizon Enterprise Ltd | 5.4% | ||
| Ezbon International Ltd | 1.7% | ||
| Montrago Trustees Ltd | 7.2% | ||
| Skorpios Trust | 7.2% | ||
|
FMR LLC
13G
|
10.7% |
6/6/2025
Event 5/30/2025
|
|
| FMR LLC | 10.7% | ||
| Abigail P. Johnson | 10.7% | ||
| BlackRock, Inc. 13G/A Amendment 1 | 5.8% |
4/16/2025
Event 3/31/2025
|
|
| BlackRock Portfolio Management LLC 13G | 5.1% |
4/15/2025
Event 3/31/2025
|
|
|
RTW Investments, LP
13G/A
Amendment 6
|
10.0% |
2/14/2025
Event 12/31/2024
|
|
| RTW Investments, LP | 10.0% | ||
| Roderick Wong, M.D. | 10.0% | ||
|
Morgan Stanley
13G/A
Amendment 2
|
6.5% |
2/3/2025
Event 12/31/2024
|
|
| Morgan Stanley | 6.5% | ||
| Morgan Stanley Capital Services LLC | 5.4% | ||
|
Skorpios Trust
13D/A
Amendment 3
|
13.0% |
12/27/2024
Event 12/23/2024
|
|
| Blue Horizon Enterprise Ltd. | 5.6% | ||
| Ezbon International Limited | 7.4% | ||
| Montrago Trustees Limited | 13.0% | ||
| Skorpios Trust | 13.0% |
| Period | Filings | Shares, Excl. Options | Value, Excl. Options |
|---|---|---|---|
| 2026 Q3 | 3 | 2.84 k | $73.8 k |
| 2026 Q2 | 203 | 79.0 M | $2.58 B |
| 2026 Q1 | 207 | 71.1 M | $2.31 B |
| 2025 Q4 | 193 | 67.0 M | $2.13 B |
| 2025 Q3 | 159 | 67.7 M | $1.57 B |
| 2025 Q2 | 138 | 68.9 M | $782 M |
| 2025 Q1 | 130 | 63.4 M | $422 M |
| 2024 Q4 | 135 | 58.3 M | $643 M |
| 2024 Q3 | 126 | 58.6 M | $720 M |
| 2024 Q2 | 124 | 66.1 M | $893 M |
| 2024 Q1 | 117 | 62.5 M | $843 M |
| 2023 Q4 | 89 | 50.0 M | $263 M |
| 2023 Q3 | 104 | 44.0 M | $173 M |
| 2023 Q2 | 107 | 46.5 M | $495 M |
| 2023 Q1 | 100 | 44.6 M | $372 M |
| 2022 Q4 | 111 | 40.7 M | $376 M |
| 2022 Q3 | 108 | 42.3 M | $544 M |
| 2022 Q2 | 96 | 43.1 M | $569 M |
| 2022 Q1 | 103 | 41.4 M | $871 M |
| 2021 Q4 | 98 | 35.5 M | $856 M |
| 2021 Q3 | 92 | 19.4 M | $492 M |
| 2021 Q2 | 102 | 20.9 M | $703 M |
| 2021 Q1 | 114 | 39.1 M | $1.52 B |
| 2020 Q4 | 103 | 38.7 M | $2.40 B |
| 2020 Q3 | 93 | 34.6 M | $1.16 B |
| 2020 Q2 | 72 | 34.9 M | $825 M |
| 2020 Q1 | 69 | 34.8 M | $796 M |
| 2019 Q4 | 66 | 33.6 M | $952 M |
| 2019 Q3 | 56 | 16.1 M | $341 M |
| 2019 Q2 | 49 | 14.3 M | $410 M |