Investors who own more than 5% of a class must file a Schedule 13D or 13G. Each filer's latest filing for 045396207 since 12/18/2024, largest first.
| Filer | % of Class | Filed | ||
|---|---|---|---|---|
|
Commodore Capital LP
13G
|
9.9% |
8/15/2025
Event 8/8/2025
|
||
| Commodore Capital LP | 9.9% | |||
| Commodore Capital Master LP | 9.9% | |||
| Robert Egen Atkinson | 9.9% | |||
| Michael Kramarz | 9.9% | |||
|
RA Capital Management, L.P.
13G
|
9.5% |
8/18/2025
Event 8/11/2025
|
||
| RA Capital Management, L.P. | 9.5% | |||
| Peter Kolchinsky | 9.5% | |||
| Rajeev Shah | 9.5% | |||
| RA Capital Healthcare Fund, L.P. | 9.5% | |||
|
Farallon Capital Management, L.L.C.
13G/A
|
8.1% |
8/4/2026
Event 6/30/2026
|
||
| Farallon Capital Management, L.L.C. | 8.1% | |||
| Farallon Capital Partners, L.P. | 0% | |||
| Farallon Capital Institutional Partners, L.P. | 0% | |||
| Farallon Capital Institutional Partners II, L.P. | 0% | |||
| Farallon Capital Institutional Partners III, L.P. | 0% | |||
| Four Crossings Institutional Partners V, L.P. | 0% | |||
| Farallon Capital Offshore Investors II, L.P. | 0% | |||
| Farallon Capital (AM) Investors, L.P. | 0% | |||
| Farallon Capital F5 Master I, L.P. | 0% | |||
| Farallon Partners, L.L.C. | 0% | |||
| Farallon Institutional (GP) V, L.L.C. | 0% | |||
| Farallon F5 (GP), L.L.C. | 0% | |||
| Dapice Joshua J. | 8.1% | |||
| Dreyfuss, Philip D. | 8.1% | |||
| Dunn Hannah E. | 8.1% | |||
| Gehani, Varun N. | 8.1% | |||
| Giauque, Nicolas | 8.1% | |||
| Husen, Avner A. | 8.1% | |||
| Kim, David T. | 8.1% | |||
| Linn, Michael G. | 8.1% | |||
| Luo Patrick (Cheng) | 8.1% | |||
| Roberts, Jr., Thomas G. | 8.1% | |||
| Saito Edric C. | 8.1% | |||
| Short Daniel S. | 8.1% | |||
| Spokes, Andrew J. M. | 8.1% | |||
| Warren, John R. | 8.1% | |||
| Wehrly, Mark C. | 8.1% | |||
|
Paradigm Biocapital Advisors LP
13G/A
|
7.8% |
8/14/2026
Event 6/30/2026
|
||
| Paradigm BioCapital Advisors LP | 7.8% | |||
| Paradigm BioCapital Advisors GP LLC | 7.8% | |||
| Senai Asefaw, M.D. | 7.8% | |||
| Paradigm BioCapital International Fund Ltd. | 6.9% | |||
|
Farallon Capital Partners, L.P.
13G/A
|
7.8% |
2/9/2026
Event 12/31/2025
|
||
| Farallon Capital Partners, L.P. | 1.5% | |||
| Farallon Capital Institutional Partners, L.P. | 1.4% | |||
| Farallon Capital Institutional Partners II, L.P. | 0.5% | |||
| Farallon Capital Institutional Partners III, L.P. | 0.3% | |||
| Four Crossings Institutional Partners V, L.P. | 0.4% | |||
| Farallon Capital Offshore Investors II, L.P. | 3.1% | |||
| Farallon Capital (AM) Investors, L.P. | 0.2% | |||
| Farallon Capital F5 Master I, L.P. | 0.3% | |||
| Farallon Partners, L.L.C. | 7.4% | |||
| Farallon Institutional (GP) V, L.L.C. | 0.4% | |||
| Farallon F5 (GP), L.L.C. | 0.3% | |||
| Dapice Joshua J. | 7.8% | |||
| Dreyfuss, Philip D. | 7.8% | |||
| Dunn Hannah E. | 7.8% | |||
| Fried, Richard B | 0% | |||
| Gehani, Varun N. | 7.8% | |||
| Giauque, Nicolas | 7.8% | |||
| Husen, Avner A. | 7.8% | |||
| Kim, David T. | 7.8% | |||
| Linn, Michael G. | 7.8% | |||
| Luo Patrick (Cheng) | 7.8% | |||
| Patel, Rajiv A. | 0% | |||
| Roberts, Jr., Thomas G. | 7.8% | |||
| Saito Edric C. | 7.8% | |||
| Seybold, William | 0% | |||
| Short Daniel S. | 7.8% | |||
| Spokes, Andrew J. M. | 7.8% | |||
| Warren, John R. | 7.8% | |||
| Wehrly, Mark C. | 7.8% | |||
| Janus Henderson Group Ltd. 13G/A | 6.9% |
8/13/2026
Event 6/30/2026
|
||
| Under 5%, checked the "5 percent or less" box, or amended by a later filing (2) | ||||
|
Armistice Capital, LLC
13G/A
|
10.0% |
8/14/2025
Event 6/30/2025
|
||
| Armistice Capital, LLC | 10.0% | |||
| Steven Boyd | 10.0% | |||
| Alexander Schornstein 13G/A | 3.5% |
8/18/2025
Event 8/11/2025
|
||
| Period | Filings | Shares, Excl. Options | Value, Excl. Options |
|---|---|---|---|
| 2026 Q3 | 1 | 20.0 | $470.00 |
| 2026 Q2 | 96 | 18.8 M | $515 M |
| 2026 Q1 | 76 | 13.8 M | $382 M |
| 2025 Q4 | 69 | 13.7 M | $467 M |
| 2025 Q3 | 60 | 12.5 M | $325 M |
| 2025 Q2 | 35 | 3.15 M | $57.1 M |
| 2025 Q1 | 38 | 3.18 M | $30.4 M |
| 2024 Q4 | 36 | 3.19 M | $50.3 M |
| 2024 Q3 | 32 | 1.03 M | $15.6 M |
| 2024 Q2 | 31 | 1.18 M | $16.1 M |
| 2024 Q1 | 28 | 652 k | $8.68 M |