Investors who own more than 5% of a class must file a Schedule 13D or 13G. Every filing for 00166B105 since 12/18/2024, newest first.
| Filer | % of Class | Filed |
|---|---|---|
|
TCG Crossover GP II, LLC
13G/A
Amendment 1
|
4.2% |
8/14/2026
Event 6/30/2026
|
| TCG Crossover GP II, LLC | 2.1% | |
| TCG Crossover Fund II, L.P. | 2.1% | |
| TCG Crossover GP III, LLC | 2.1% | |
| TCG Crossover Fund III, L.P. | 2.1% | |
| Chen Yu | 4.2% | |
| BlackRock, Inc. 13G | 5.4% |
7/27/2026
Event 6/30/2026
|
|
LSV Associates, LLC
13D/A
Amendment 3
|
2.2% |
5/27/2026
Event 5/27/2026
|
| LSV Associates, LLC | 1.2% | |
| Lightstone Ventures, L.P. | 1.0% | |
| Lightstone Ventures (A), L.P. | 0.1% | |
| LSV Associates II, LLC | 1.0% | |
| Lightstone Ventures II, L.P. | 1.0% | |
| Lightstone Ventures II (A), L.P. | 0.1% | |
| Michael A Carusi | 2.2% | |
| Jean George | 2.2% | |
| Henry A. Plain Jr | 2.2% | |
|
Redmile Group, LLC
13G/A
Amendment 3
|
6.8%
Checked 5% or less
|
5/15/2026
Event 3/31/2026
|
| Redmile Group, LLC | 6.8% | |
| Jeremy C. Green | 6.8% | |
| Redmile Biopharma Investments III, L.P. | 3.9% | |
| HBM Healthcare Investments (Cayman) Ltd. 13G/A Amendment 2 | 6.5% |
5/15/2026
Event 3/31/2026
|
|
Millennium Management LLC
13G/A
Amendment 2
|
1.5% |
4/28/2026
Event 3/31/2026
|
| Integrated Core Strategies (US) LLC | 0.5% | |
| Millennium Management LLC | 1.5% | |
| Millennium Group Management LLC | 1.5% | |
| Israel A. Englander | 1.5% | |
|
RA Capital Management, L.P.
13G
|
9.9% |
2/9/2026
Event 2/2/2026
|
| RA Capital Management, L.P. | 9.9% | |
| Peter Kolchinsky | 9.9% | |
| Rajeev Shah | 9.9% | |
| RA Capital Healthcare Fund, L.P. | 9.9% | |
|
TCG Crossover GP II, LLC
13G
|
9.9% |
2/6/2026
Event 1/30/2026
|
| TCG Crossover GP II, LLC | 5.0% | |
| TCG Crossover Fund II, L.P. | 5.0% | |
| TCG Crossover GP III, LLC | 5.0% | |
| TCG Crossover Fund III, L.P. | 5.0% | |
| Chen Yu | 9.9% | |
|
venBio Global Strategic Fund, L.P.
13D/A
Amendment 1
|
10.0% |
2/4/2026
Event 2/2/2026
|
| venBio Global Strategic Fund, L.P. | 3.4% | |
| venBio Global Strategic Fund II L.P. | 6.4% | |
| venBio Global Strategic GP, L.P. | 3.4% | |
| venBio Global Strategic GP II, L.P. | 6.4% | |
| venBio Global Strategic GP, Ltd. | 3.4% | |
| venBio Global Strategic GP II, Ltd. | 6.4% | |
| Adelman Robert J | 9.9% | |
| Goodman Corey S | 10.0% | |
|
Tang Capital Management LLC
13G/A
Amendment 3
|
0% |
11/14/2025
Event 9/30/2025
|
| Tang Capital Management, LLC | 0% | |
| Kevin Tang | 0% | |
| Tang Capital Partners, LP | 0% | |
| Tang Capital Partners International, LP | 0% | |
| Tang Capital Partners III, Inc | 0% | |
| Tang Capital Partners IV, Inc | 0% | |
|
Tang Capital Management LLC
13G/A
Amendment 3
|
0% |
11/14/2025
Event 9/30/2025
|
| Tang Capital Management, LLC | 0% | |
| Kevin Tang | 0% | |
| Tang Capital Partners, LP | 0% | |
| Tang Capital Partners International, LP | 0% | |
| Tang Capital Partners III, Inc | 0% | |
| Tang Capital Partners IV, Inc | 0% | |
|
Millennium Management LLC
13G/A
Amendment 1
|
6.0% |
10/22/2025
Event 10/17/2025
|
| Integrated Core Strategies (US) LLC | 5.1% | |
| Millennium Management LLC | 6.0% | |
| Millennium Group Management LLC | 6.0% | |
| Israel A. Englander | 6.0% | |
|
Millennium Management LLC
13G
|
5.1% |
10/8/2025
Event 10/2/2025
|
| Millennium Management LLC | 5.1% | |
| Millennium Group Management LLC | 5.1% | |
| Israel A. Englander | 5.1% | |
|
Redmile Group, LLC
13G/A
Amendment 2
|
8.5% |
8/14/2025
Event 6/30/2025
|
| Redmile Group, LLC | 8.5% | |
| Jeremy C. Green | 8.5% | |
| Redmile Biopharma Investments III, L.P. | 6.7% | |
|
Tang Capital Management LLC
13G/A
Amendment 2
|
5.9% |
5/15/2025
Event 3/31/2025
|
| Tang Capital Management, LLC | 5.9% | |
| Kevin Tang | 5.9% | |
| Tang Capital Partners, LP | 3.2% | |
| Tang Capital Partners International, LP | 2.7% | |
| Tang Capital Partners III, Inc | 0% | |
| Tang Capital Partners IV, Inc | 0% | |
| HBM Healthcare Investments (Cayman) Ltd. 13G/A Amendment 1 | 8.4% |
5/15/2025
Event 3/31/2025
|
|
Tang Capital Partners LP
13G/A
Amendment 1
|
6.3% |
2/14/2025
Event 12/31/2024
|
| Tang Capital Management, LLC | 6.3% | |
| Kevin Tang | 6.3% | |
| Tang Capital Partners, LP | 6.3% | |
| Tang Capital Partners III, Inc | 0% | |
| Tang Capital Partners IV, Inc | 0% | |
| HBM Healthcare Investments (Cayman) Ltd. 13G | 6.5% |
12/27/2024
Event 12/18/2024
|
|
FMR LLC
13G/A
Amendment 5
|
3.4% |
12/6/2024
Event 11/29/2024
|
| FMR LLC | 3.4% | |
| Abigail P. Johnson | 3.4% |
| Period | Filings | Shares, Excl. Options | Value, Excl. Options |
|---|---|---|---|
| 2026 Q2 | 97 | 106 M | $221 M |
| 2026 Q1 | 72 | 94.3 M | $189 M |
| 2025 Q4 | 64 | 29.2 M | $33.5 M |
| 2025 Q3 | 66 | 30.4 M | $56.0 M |
| 2025 Q2 | 65 | 29.1 M | $12.6 M |
| 2025 Q1 | 89 | 34.8 M | $22.1 M |
| 2024 Q4 | 95 | 41.1 M | $69.0 M |
| 2024 Q3 | 99 | 45.5 M | $83.2 M |
| 2024 Q2 | 125 | 49.3 M | $298 M |
| 2024 Q1 | 116 | 46.5 M | $519 M |
| 2023 Q4 | 103 | 46.3 M | $690 M |
| 2023 Q3 | 82 | 33.3 M | $160 M |
| 2023 Q2 | 81 | 34.3 M | $258 M |
| 2023 Q1 | 90 | 35.7 M | $161 M |
| 2022 Q4 | 93 | 36.8 M | $415 M |
| 2022 Q3 | 102 | 36.4 M | $349 M |
| 2022 Q2 | 101 | 35.9 M | $291 M |
| 2022 Q1 | 101 | 36.9 M | $624 M |
| 2021 Q4 | 114 | 36.3 M | $781 M |
| 2021 Q3 | 121 | 34.5 M | $2.55 B |
| 2021 Q2 | 111 | 33.4 M | $1.83 B |
| 2021 Q1 | 100 | 33.5 M | $2.47 B |
| 2020 Q4 | 96 | 32.3 M | $2.78 B |
| 2020 Q3 | 58 | 27.3 M | $1.03 B |