Investors who own more than 5% of a class must file a Schedule 13D or 13G. The latest filing for each security since 12/18/2024, newest first.
| Issuer | % of Class | Filed | |||
|---|---|---|---|---|---|
|
Obsidian Therapeutics, Inc.
13G
OBX · 67448A106
|
6.6% |
10/5/2026
Event 9/28/2026
|
|||
| Paradigm BioCapital Advisors LP | 6.6% | ||||
| Paradigm BioCapital Advisors GP LLC | 6.6% | ||||
| Senai Asefaw, M.D. | 6.6% | ||||
| Paradigm BioCapital International Fund Ltd. | 5.9% | ||||
|
Spyre Therapeutics, Inc.
13G
SYRE · 00773J202
|
5.1% |
10/1/2026
Event 9/24/2026
|
|||
| Paradigm BioCapital Advisors LP | 5.1% | ||||
| Paradigm BioCapital Advisors GP LLC | 5.1% | ||||
| Senai Asefaw, M.D. | 5.1% | ||||
| Paradigm BioCapital International Fund Ltd. | 4.5% | ||||
|
Tyra Biosciences, Inc.
13G
TYRA · 90240B106
|
5.8% |
9/17/2026
Event 9/10/2026
|
|||
| Paradigm BioCapital Advisors LP | 5.8% | ||||
| Paradigm BioCapital Advisors GP LLC | 5.8% | ||||
| Senai Asefaw, M.D. | 5.8% | ||||
| Paradigm BioCapital International Fund Ltd. | 5.1% | ||||
|
Arcellx, Inc.
13G/A
ACLX · 03940C100
|
0% |
8/14/2026
Event 6/30/2026
|
|||
| Paradigm BioCapital Advisors LP | 0% | ||||
| Paradigm BioCapital Advisors GP LLC | 0% | ||||
| Senai Asefaw, M.D. | 0% | ||||
| Paradigm BioCapital International Fund Ltd. | 0% | ||||
|
Assembly Biosciences, Inc.
13G/A
ASMB · 045396207
|
7.8% |
8/14/2026
Event 6/30/2026
|
|||
| Paradigm BioCapital Advisors LP | 7.8% | ||||
| Paradigm BioCapital Advisors GP LLC | 7.8% | ||||
| Senai Asefaw, M.D. | 7.8% | ||||
| Paradigm BioCapital International Fund Ltd. | 6.9% | ||||
|
Viridian Therapeutics, Inc.
13G/A
VRDN · 92790C104
|
6.1% |
8/14/2026
Event 6/30/2026
|
|||
| Paradigm BioCapital Advisors LP | 6.1% | ||||
| Paradigm BioCapital Advisors GP LLC | 6.1% | ||||
| Senai Asefaw, M.D. | 6.1% | ||||
| Paradigm BioCapital International Fund Ltd. | 5.3% | ||||
|
Lexeo Therapeutics, Inc.
13G/A
LXEO · 52886X107
|
5.3% |
8/14/2026
Event 6/30/2026
|
|||
| Paradigm BioCapital Advisors LP | 5.3% | ||||
| Paradigm BioCapital Advisors GP LLC | 5.3% | ||||
| Senai Asefaw, M.D. | 5.3% | ||||
| Paradigm BioCapital International Fund Ltd. | 4.7% | ||||
|
Edgewise Therapeutics, Inc.
13G/A
EWTX · 28036F105
|
9.5% |
8/14/2026
Event 6/30/2026
|
|||
| Paradigm BioCapital Advisors LP | 9.5% | ||||
| Paradigm BioCapital Advisors GP LLC | 9.5% | ||||
| Senai Asefaw, M.D. | 9.5% | ||||
| Paradigm BioCapital International Fund Ltd. | 8.3% | ||||
|
Maze Therapeutics, Inc.
13G/A
MAZE · 578784100
|
0% |
8/14/2026
Event 6/30/2026
|
|||
| Paradigm BioCapital Advisors LP | 0% | ||||
| Paradigm BioCapital Advisors GP LLC | 0% | ||||
| Senai Asefaw, M.D. | 0% | ||||
| Paradigm BioCapital International Fund Ltd. | 0% | ||||
|
Jade Biosciences, Inc.
13G
JBIO · 008064206
|
5.1% |
7/17/2026
Event 7/10/2026
|
|||
| Paradigm BioCapital Advisors LP | 5.1% | ||||
| Paradigm BioCapital Advisors GP LLC | 5.1% | ||||
| Senai Asefaw, M.D. | 5.1% | ||||
| Paradigm BioCapital International Fund Ltd. | 4.5% | ||||
|
MBX Biosciences, Inc.
13G
MBX · 55287L101
|
5.2% |
6/24/2026
Event 6/16/2026
|
|||
| Paradigm BioCapital Advisors LP | 5.2% | ||||
| Paradigm BioCapital Advisors GP LLC | 5.2% | ||||
| Senai Asefaw, M.D. | 5.2% | ||||
| Paradigm BioCapital International Fund Ltd. | 4.6% | ||||
|
EyePoint, Inc.
13G/A
EYPT · 30233G209
|
3.8% |
5/15/2026
Event 3/31/2026
|
|||
| Paradigm BioCapital Advisors LP | 3.8% | ||||
| Paradigm BioCapital Advisors GP LLC | 3.8% | ||||
| Senai Asefaw, M.D. | 3.8% | ||||
| Paradigm BioCapital International Fund Ltd. | 3.3% | ||||
|
UroGen Pharma Ltd.
13G/A
URGN · M96088105
|
3.5% |
5/15/2026
Event 3/31/2026
|
|||
| Paradigm BioCapital Advisors LP | 3.5% | ||||
| Paradigm BioCapital Advisors GP LLC | 3.5% | ||||
| Senai Asefaw, M.D. | 3.5% | ||||
| Paradigm BioCapital International Fund Ltd. | 3.1% | ||||
|
Erasca, Inc.
13G/A
ERAS · 29479A108
|
3.3% |
5/15/2026
Event 3/31/2026
|
|||
| Paradigm BioCapital Advisors LP | 3.3% | ||||
| Paradigm BioCapital Advisors GP LLC | 3.3% | ||||
| Senai Asefaw, M.D. | 3.3% | ||||
| Paradigm BioCapital International Fund Ltd. | 2.9% | ||||
|
Achieve Life Sciences, Inc.
13G
ACHV · 004468500
|
9.2% |
4/24/2026
Event 4/17/2026
|
|||
| Paradigm BioCapital Advisors LP | 9.2% | ||||
| Paradigm BioCapital Advisors GP LLC | 9.2% | ||||
| Senai Asefaw, M.D. | 9.2% | ||||
| Paradigm BioCapital International Fund Ltd. | 8.1% | ||||
|
Merus N.V.
13G/A
MRUS · N5749R100
|
0% |
2/17/2026
Event 12/31/2025
|
|||
| Paradigm BioCapital Advisors LP | 0% | ||||
| Paradigm BioCapital Advisors GP LLC | 0% | ||||
| Senai Asefaw, M.D. | 0% | ||||
| Paradigm BioCapital International Fund Ltd. | 0% | ||||
|
VOR Biopharma Inc.
13G/A
VOR · 929033207
|
4.5% |
2/17/2026
Event 12/31/2025
|
|||
| Paradigm BioCapital Advisors LP | 4.5% | ||||
| Paradigm BioCapital Advisors GP LLC | 4.5% | ||||
| Senai Asefaw, M.D. | 4.5% | ||||
| Paradigm BioCapital International Fund Ltd. | 4.0% | ||||
|
Cogent Biosciences, Inc.
13G/A
COGT · 19240Q201
|
2.3% |
11/14/2025
Event 9/30/2025
|
|||
| Paradigm BioCapital Advisors LP | 2.3% | ||||
| Paradigm BioCapital Advisors GP LLC | 2.3% | ||||
| Senai Asefaw, M.D. | 2.3% | ||||
| Paradigm BioCapital International Fund Ltd. | 2.0% | ||||
|
Agios Pharmaceuticals, Inc.
13G/A
AGIO · 00847X104
|
4.9% |
11/14/2025
Event 9/30/2025
|
|||
| Paradigm BioCapital Advisors LP | 4.9% | ||||
| Paradigm BioCapital Advisors GP LLC | 4.9% | ||||
| Senai Asefaw, M.D. | 4.9% | ||||
| Paradigm BioCapital International Fund Ltd. | 4.4% | ||||
|
Cidara Therapeutics, Inc.
13G/A
CDTX · 171757206
|
3.3% |
11/14/2025
Event 9/30/2025
|
|||
| Paradigm BioCapital Advisors LP | 3.3% | ||||
| Paradigm BioCapital Advisors GP LLC | 3.3% | ||||
| Senai Asefaw, M.D. | 3.3% | ||||
| Paradigm BioCapital International Fund Ltd. | 2.9% | ||||
|
LENZ Therapeutics, Inc.
13G/A
LENZ · 52635N103
|
3.8% |
11/14/2025
Event 9/30/2025
|
|||
| Paradigm BioCapital Advisors LP | 3.8% | ||||
| Paradigm BioCapital Advisors GP LLC | 3.8% | ||||
| Senai Asefaw, M.D. | 3.8% | ||||
| Paradigm BioCapital International Fund Ltd. | 3.3% | ||||
|
Y-mAbs Therapeutics, Inc.
13G/A
YMAB · 984241109
|
0% |
11/14/2025
Event 9/30/2025
|
|||
| Paradigm BioCapital Advisors LP | 0% | ||||
| Paradigm BioCapital Advisors GP LLC | 0% | ||||
| Senai Asefaw, M.D. | 0% | ||||
| Paradigm BioCapital International Fund Ltd. | 0% | ||||
|
Janux Therapeutics, Inc.
13G/A
JANX · 47103J105
|
4.9% |
8/14/2025
Event 6/30/2025
|
|||
| Paradigm BioCapital Advisors LP | 4.9% | ||||
| Paradigm BioCapital Advisors GP LLC | 4.9% | ||||
| Senai Asefaw, M.D. | 4.9% | ||||
| Paradigm BioCapital International Fund Ltd. | 4.4% | ||||
|
Disc Medicine, Inc.
13G/A
IRON · 254604101
|
3.5% |
5/15/2025
Event 3/31/2025
|
|||
| Paradigm BioCapital Advisors LP | 3.5% | ||||
| Paradigm BioCapital Advisors GP LLC | 3.5% | ||||
| Senai Asefaw, M.D. | 3.5% | ||||
| Paradigm BioCapital International Fund Ltd. | 3.1% | ||||
|
Pliant Therapeutics, Inc.
13G/A
PLRX · 729139105
|
0% |
5/15/2025
Event 3/31/2025
|
|||
| Paradigm BioCapital Advisors LP | 0% | ||||
| Paradigm BioCapital Advisors GP LLC | 0% | ||||
| Senai Asefaw, M.D. | 0% | ||||
| Paradigm BioCapital International Fund Ltd. | 0% | ||||
|
Olema Pharmaceuticals, Inc.
13G/A
OLMA · 68062P106
|
10.0% |
2/14/2025
Event 12/31/2024
|
|||
| Paradigm BioCapital Advisors LP | 10.0% | ||||
| Paradigm BioCapital Advisors GP LLC | 10.0% | ||||
| Senai Asefaw, M.D. | 10.0% | ||||
| Paradigm BioCapital International Fund Ltd. | 9.1% | ||||
|
Kura Oncology, Inc.
13G/A
KURA · 50127T109
|
0% |
2/14/2025
Event 12/31/2024
|
|||
| Paradigm BioCapital Advisors LP | 0% | ||||
| Paradigm BioCapital Advisors GP LLC | 0% | ||||
| Senai Asefaw, M.D. | 0% | ||||
| Paradigm BioCapital International Fund Ltd. | 0% | ||||