RA CAPITAL MANAGEMENT, L.P.

13D and 13G Filings

Investors who own more than 5% of a class must file a Schedule 13D or 13G. Every filing since 12/18/2024, newest first.

Issuer	Symbol	CUSIP	% of Class	Shares	Form	Filed
Tyra Biosciences, Inc. 13D/A Amendment 4 TYRA · 90240B106	TYRA	90240B106	20.1%	10,684,890	13D/A Amendment 4	3/31/2025 Event 3/27/2025
RA Capital Management, L.P.			20.1%	10,684,890
Peter Kolchinsky			20.1%	10,684,890
Rajeev Shah			20.1%	10,684,890
RA Capital Healthcare Fund, L.P.			16.4%	8,697,956
Mineralys Therapeutics, Inc. 13D/A Amendment 2 MLYS · 603170101	MLYS	603170101	9.9%	6,287,597	13D/A Amendment 2	3/17/2025 Event 3/13/2025
RA Capital Management, L.P.			9.9%	6,287,597
Peter Kolchinsky			9.9%	6,287,597
Rajeev Shah			9.9%	6,287,597
RA Capital Healthcare Fund, L.P.			6.9%	4,358,979
Janux Therapeutics, Inc. 13D/A Amendment 4 JANX · 47103J105	JANX	47103J105	19.9%	11,971,377	13D/A Amendment 4	3/10/2025 Event 3/6/2025
RA Capital Management, L.P.			19.9%	11,971,377
Peter Kolchinsky			19.9%	11,971,377
Rajeev Shah			19.9%	11,971,377
RA Capital Healthcare Fund, L.P.			18.2%	10,861,013
89BIO, Inc. 13D/A Amendment 13 ETNB · 282559103	ETNB	282559103	13.7%	20,013,733	13D/A Amendment 13	3/3/2025 Event 2/27/2025
RA Capital Management, L.P.			13.7%	20,013,733
Peter Kolchinsky			13.7%	20,013,733
Rajeev Shah			13.7%	20,013,733
RA Capital Healthcare Fund, L.P.			13.4%	19,554,319
Solid Biosciences Inc. 13D/A Amendment 9 SLDB · 83422E105	SLDB	83422E105	9.9%	7,989,820	13D/A Amendment 9	2/21/2025 Event 2/19/2025
RA Capital Management, L.P.			9.9%	7,989,820
Peter Kolchinsky			9.9%	7,989,820
Rajeev Shah			9.9%	7,989,820
RA Capital Healthcare Fund, L.P.			9.8%	7,823,558
Sionna Therapeutics, Inc. 13D SION · 829401108	SION	829401108	23.7%	10,445,322	13D	2/18/2025 Event 2/10/2025
RA Capital Management, L.P.			23.7%	10,445,322
Peter Kolchinsky			23.7%	10,445,322
Rajeev Shah			23.7%	10,445,322
RA Capital Healthcare Fund, L.P.			15.7%	6,923,365
RA Capital Nexus Fund III, L.P.			5.3%	2,324,498
Verona Pharma plc 13G/A Amendment 5 VRNA · 925050106	VRNA	925050106	8.9%	7,777,942	13G/A Amendment 5	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			8.9%	7,777,942
Peter Kolchinsky			8.9%	7,777,942
Rajeev Shah			8.9%	7,777,942
RA Capital Healthcare Fund, L.P.			8.9%	7,777,942
Unicycive Therapeutics, Inc. 13G/A Amendment 3 UNCY · 90466Y103	UNCY	90466Y103	9.9%	11,520,120	13G/A Amendment 3	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			9.9%	11,520,120
Peter Kolchinsky			9.9%	11,520,120
Rajeev Shah			9.9%	11,520,120
RA Capital Healthcare Fund, L.P.			9.9%	11,520,120
Tenaya Therapeutics, Inc. 13G/A Amendment 4 TNYA · 87990A106	TNYA	87990A106	0%	0	13G/A Amendment 4	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			0%	0
Peter Kolchinsky			0%	0
Rajeev Shah			0%	0
RA Capital Healthcare Fund, L.P.			0%	0
Newamsterdam Pharma Company N.V. 13G/A Amendment 4 NAMS · N62509109	NAMS	N62509109	9.9%	10,875,454	13G/A Amendment 4	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			9.9%	10,875,454
Peter Kolchinsky			9.9%	10,875,454
Rajeev Shah			9.9%	10,875,454
RA Capital Healthcare Fund, L.P.			9.9%	10,875,454
Recursion Pharmaceuticals, Inc. 13G/A Amendment 1 RXRX · 75629V104	RXRX	75629V104	2.0%	7,725,096	13G/A Amendment 1	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			2.0%	7,725,096
Peter Kolchinsky			2.0%	7,725,096
Rajeev Shah			2.0%	7,725,096
RA Capital Healthcare Fund, L.P.			2.0%	7,725,096
Protara Therapeutics, Inc. 13G/A Amendment 1 TARA · 74365U107	TARA	74365U107	9.9%	3,431,713	13G/A Amendment 1	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			9.9%	3,431,713
Peter Kolchinsky			9.9%	3,431,713
Rajeev Shah			9.9%	3,431,713
RA Capital Healthcare Fund, L.P.			9.9%	3,431,713
Macrogenics, Inc. 13G/A Amendment 2 MGNX · 556099109	MGNX	556099109	0%	0	13G/A Amendment 2	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			0%	0
Peter Kolchinsky			0%	0
Rajeev Shah			0%	0
RA Capital Healthcare Fund, L.P.			0%	0
Longboard Pharmaceuticals, Inc. 13G/A Amendment 1 LBPH · 54300N103	LBPH	54300N103	0%	0	13G/A Amendment 1	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			0%	0
Peter Kolchinsky			0%	0
Rajeev Shah			0%	0
RA Capital Healthcare Fund, L.P.			0%	0
GlycoMimetics, Inc. 13G/A Amendment 1 GLYC · 38000Q102	GLYC	38000Q102	0%	0	13G/A Amendment 1	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			0%	0
Peter Kolchinsky			0%	0
Rajeev Shah			0%	0
RA Capital Healthcare Fund, L.P.			0%	0
EyePoint Pharmaceuticals, Inc. 13G/A Amendment 3 EYPT · 30233G209	EYPT	30233G209	4.7%	3,181,818	13G/A Amendment 3	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			4.7%	3,181,818
Peter Kolchinsky			4.7%	3,181,818
Rajeev Shah			4.7%	3,181,818
RA Capital Healthcare Fund, L.P.			4.7%	3,181,818
Evolent Health, Inc. 13G/A Amendment 1 EVH · 30050B101	EVH	30050B101	3.1%	3,577,197	13G/A Amendment 1	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			3.1%	3,577,197
Peter Kolchinsky			3.1%	3,577,197
Rajeev Shah			3.1%	3,577,197
RA Capital Healthcare Fund, L.P.			3.1%	3,577,197
Ensysce Biosciences, Inc. 13G/A Amendment 2 ENSC · 293602405	ENSC	293602405	0%	0	13G/A Amendment 2	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			0%	0
Peter Kolchinsky			0%	0
Rajeev Shah			0%	0
RA Capital Healthcare Fund, L.P.			0%	0
Dianthus Therapeutics, Inc. 13G/A Amendment 1 DNTH · 252828108	DNTH	252828108	9.4%	2,866,733	13G/A Amendment 1	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			9.4%	2,866,733
Peter Kolchinsky			9.4%	2,866,733
Rajeev Shah			9.4%	2,866,733
RA Capital Healthcare Fund, L.P.			9.4%	2,866,733
Day One Biopharmaceuticals, Inc. 13G/A Amendment 3 DAWN · 23954D109	DAWN	23954D109	5.7%	5,755,577	13G/A Amendment 3	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			5.7%	5,755,577
Peter Kolchinsky			5.7%	5,755,577
Rajeev Shah			5.7%	5,755,577
RA Capital Healthcare Fund, L.P.			5.3%	5,307,848
Adagio Medical Holdings, Inc. 13G/A Amendment 1 ADGM · 00534B100	ADGM	00534B100	9.9%	1,613,220	13G/A Amendment 1	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			9.9%	1,613,220
Peter Kolchinsky			9.9%	1,613,220
Rajeev Shah			9.9%	1,613,220
RA Capital Healthcare Fund, L.P.			9.7%	1,613,220
4D Molecular Therapeutics, Inc. 13G/A Amendment 4 FDMT · 35104E100	FDMT	35104E100	9.9%	4,564,867	13G/A Amendment 4	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			9.9%	4,564,867
Peter Kolchinsky			9.9%	4,564,867
Rajeev Shah			9.9%	4,564,867
RA Capital Healthcare Fund, L.P.			9.9%	4,564,867
Cytek Biosciences, Inc. 13G/A Amendment 1 CTKB · 23285D109	CTKB	23285D109	0%	0	13G/A Amendment 1	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			0%	0
Peter Kolchinsky			0%	0
Rajeev Shah			0%	0
RA Capital Healthcare Fund, L.P.			0%	0
Cybin Inc. 13G/A Amendment 1 CYBN · 23256X100	CYBN	23256X100	0%	0	13G/A Amendment 1	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			0%	0
Peter Kolchinsky			0%	0
Rajeev Shah			0%	0
RA Capital Healthcare Fund, L.P.			0%	0
CervoMed Inc. 13G/A Amendment 1 CRVO · 15713L109	CRVO	15713L109	9.9%	916,063	13G/A Amendment 1	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			9.9%	916,063
Peter Kolchinsky			9.9%	916,063
Rajeev Shah			9.9%	916,063
RA Capital Healthcare Fund, L.P.			9.9%	916,063
Bioage Labs, Inc. 13G/A Amendment 1 BIOA · 09077V100	BIOA	09077V100	3.7%	1,310,589	13G/A Amendment 1	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			3.7%	1,310,589
Peter Kolchinsky			3.7%	1,310,589
Rajeev Shah			3.7%	1,310,589
RA Capital Healthcare Fund, L.P.			2.7%	982,942
AN2 Therapeutics, Inc. 13G/A Amendment 4 ANTX · 037326105	ANTX	037326105	0%	0	13G/A Amendment 4	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			0%	0
Peter Kolchinsky			0%	0
Rajeev Shah			0%	0
RA Capital Healthcare Fund, L.P.			0%	0
Alto Neuroscience, Inc. 13G/A Amendment 2 ANRO · 02157Q109	ANRO	02157Q109	0%	0	13G/A Amendment 2	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			0%	0
Peter Kolchinsky			0%	0
Rajeev Shah			0%	0
RA Capital Healthcare Fund, L.P.			0%	0
Monopar Therapeutics Inc. 13G/A Amendment 1 MNPR · 61023L207	MNPR	61023L207	9.9%	620,116	13G/A Amendment 1	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			9.9%	620,116
Peter Kolchinsky			9.9%	620,116
Rajeev Shah			9.9%	620,116
RA Capital Healthcare Fund, L.P.			9.9%	620,116
Zura Bio Limited 13G/A Amendment 1 ZURA · G9TY5A101	ZURA	G9TY5A101	4.9%	3,217,503	13G/A Amendment 1	2/14/2025 Event 12/31/2024
RA Capital Management, L.P.			4.9%	3,217,503
Peter Kolchinsky			4.9%	3,217,503
Rajeev Shah			4.9%	3,217,503
RA Capital Healthcare Fund, L.P.			4.9%	3,217,503
89BIO, Inc. 13D/A Amendment 12 ETNB · 282559103	ETNB	282559103	15.1%	20,013,733	13D/A Amendment 12	2/3/2025 Event 1/30/2025
RA Capital Management, L.P.			15.1%	20,013,733
Peter Kolchinsky			15.1%	20,013,733
Rajeev Shah			15.1%	20,013,733
RA Capital Healthcare Fund LP			14.8%	19,554,319
Vor Biopharma Inc. 13D/A Amendment 4 VOR · 929033108	VOR	929033108	31.9%	39,709,850	13D/A Amendment 4	12/30/2024 Event 12/26/2024
RA Capital Management, L.P.			31.9%	39,709,850
Peter Kolchinsky			31.9%	39,709,850
Rajeev Shah			31.9%	39,709,850
RA Capital Healthcare Fund LP			30.4%	37,820,713