Investors who own more than 5% of a class must file a Schedule 13D or 13G. Every filing for N44445109 since 12/18/2024, newest first.
| Filer | % of Class | Filed | |
|---|---|---|---|
|
Perceptive Advisors LLC
13D/A
Amendment 2
|
7.6% |
8/27/2026
Event 8/26/2026
|
|
| Perceptive Advisors LLC | 7.6% | ||
| Perceptive Life Sciences Master Fund, Ltd. | 7.6% | ||
| Joseph Edelman | 7.6% | ||
|
Baker Bros. Advisors LP
13G/A
Amendment 6
|
7.0% |
8/14/2026
Event 6/30/2026
|
|
| Baker Bros. Advisors LP | 7.0% | ||
| Baker Bros. Advisors (GP) LLC | 7.0% | ||
| Julian C. Baker | 7.0% | ||
| Felix J. Baker | 7.0% | ||
| T. Rowe Price Investment Management, Inc. 13G/A Amendment 4 | 16.1% |
5/15/2026
Event 3/31/2026
|
|
|
RTW Investments, LP
13G/A
Amendment 4
|
9.6% |
5/15/2026
Event 3/31/2026
|
|
| RTW Investments, LP | 9.6% | ||
| Roderick Wong | 9.6% | ||
| Toronto Dominion Bank 13G | 5.5% |
5/15/2026
Event 3/31/2026
|
|
|
Vestal Point Capital, LP
13G/A
Amendment 1
|
4.6% |
5/15/2026
Event 3/31/2026
|
|
| Vestal Point Capital, LP | 4.6% | ||
| Ryan Wilder | 4.6% | ||
|
RTW Investments, LP
13G/A
Amendment 3
|
8.5% |
2/17/2026
Event 12/31/2025
|
|
| RTW Investments, LP | 8.5% | ||
| Roderick Wong | 8.5% | ||
|
Suvretta Capital Management, LLC
13G/A
Amendment 3
|
8.3% |
2/13/2026
Event 12/31/2025
|
|
| Suvretta Capital Management, LLC | 8.3% | ||
| Averill Master Fund, Ltd | 7.1% | ||
| Aaron Cowen | 8.3% | ||
|
RTW Investments, LP
13G/A
Amendment 2
|
7.3% |
11/14/2025
Event 9/30/2025
|
|
| RTW Investments, LP | 7.3% | ||
| Roderick Wong | 7.3% | ||
|
Baker Bros. Advisors LP
13G/A
Amendment 5
|
10.0% |
11/14/2025
Event 9/30/2025
|
|
| Baker Bros. Advisors LP | 10.0% | ||
| Baker Bros. Advisors (GP) LLC | 10.0% | ||
| Julian C. Baker | 10.0% | ||
| Felix J. Baker | 10.0% | ||
| T. Rowe Price Investment Management, Inc. 13G/A Amendment 3 | 15.1% |
8/14/2025
Event 6/30/2025
|
|
|
Baker Bros. Advisors LP
13G/A
Amendment 4
|
8.4% |
8/14/2025
Event 6/30/2025
|
|
| Baker Bros. Advisors LP | 8.4% | ||
| Baker Bros. Advisors (GP) LLC | 8.4% | ||
| Julian C. Baker | 8.4% | ||
| Felix J. Baker | 8.4% | ||
|
Suvretta Capital Management, LLC
13G/A
Amendment 2
|
9.9% |
8/13/2025
Event 6/30/2025
|
|
| Suvretta Capital Management, LLC | 9.9% | ||
| Averill Master Fund, Ltd. | 8.7% | ||
| Aaron Cowen | 9.9% | ||
|
Wellington Management Group LLP
13G/A
Amendment 4
|
4.4% |
8/12/2025
Event 6/30/2025
|
|
| Wellington Management Group LLP | 4.4% | ||
| Wellington Group Holdings LLP | 4.4% | ||
| Wellington Investment Advisors Holdings LLP | 4.4% | ||
|
Wellington Management Group LLP
13G/A
Amendment 3
|
7.1% |
5/12/2025
Event 3/31/2025
|
|
| Wellington Management Group LLP | 7.1% | ||
| Wellington Group Holdings LLP | 7.1% | ||
| Wellington Investment Advisors Holdings LLP | 7.1% | ||
| Wellington Management Company LLP | 6.7% | ||
|
Suvretta Capital Management, LLC
13G/A
Amendment 1
|
7.5% |
5/2/2025
Event 3/31/2025
|
|
| Suvretta Capital Management, LLC | 7.5% | ||
| Averill Master Fund, Ltd. | 6.7% | ||
| Aaron Cowen | 7.5% | ||
| T. Rowe Price Investment Management, Inc. 13G/A Amendment 2 | 11.6% |
3/7/2025
Event 2/28/2025
|
|
| T. Rowe Price Investment Management, Inc. 13G/A Amendment 1 | 8.7% |
2/14/2025
Event 12/31/2024
|
|
|
Baker Bros. Advisors LP
13G/A
Amendment 3
|
6.0% |
2/14/2025
Event 12/31/2024
|
|
| Baker Bros. Advisors LP | 6.0% | ||
| Baker Bros. Advisors (GP) LLC | 6.0% | ||
| Julian C. Baker | 6.0% | ||
| Felix J. Baker | 6.0% | ||
|
RTW Investments, LP
13G/A
Amendment 1
|
5.5% |
2/14/2025
Event 12/31/2024
|
|
| RTW Investments, LP | 5.5% | ||
| Roderick Wong, M.D. | 5.5% | ||
|
Vestal Point Capital, LP
13G
|
5.3% |
2/14/2025
Event 12/31/2024
|
|
| Vestal Point Capital, LP | 5.3% | ||
| Ryan Wilder | 5.3% | ||
|
Suvretta Capital Management, LLC
13G
|
6.5% |
2/11/2025
Event 2/4/2025
|
|
| Suvretta Capital Management, LLC | 6.5% | ||
| Averill Master Fund, Ltd. | 5.7% | ||
| Aaron Cowen | 6.5% |
| Period | Filings | Shares, Excl. Options | Value, Excl. Options |
|---|---|---|---|
| 2026 Q3 | 2 | 30.1 k | $264 k |
| 2026 Q2 | 84 | 99.8 M | $1.01 B |
| 2026 Q1 | 85 | 108 M | $1.06 B |
| 2025 Q4 | 80 | 106 M | $1.12 B |
| 2025 Q3 | 66 | 92.6 M | $788 M |
| 2025 Q2 | 75 | 96.0 M | $517 M |
| 2025 Q1 | 81 | 91.4 M | $412 M |
| 2024 Q4 | 93 | 92.3 M | $656 M |
| 2024 Q3 | 102 | 76.2 M | $869 M |
| 2024 Q2 | 103 | 78.8 M | $915 M |
| 2024 Q1 | 90 | 73.3 M | $770 M |
| 2023 Q4 | 93 | 54.0 M | $569 M |
| 2023 Q3 | 92 | 44.9 M | $520 M |
| 2023 Q2 | 75 | 41.4 M | $478 M |
| 2023 Q1 | 71 | 34.8 M | $240 M |
| 2022 Q4 | 67 | 34.0 M | $297 M |
| 2022 Q3 | 59 | 22.2 M | $222 M |
| 2022 Q2 | 51 | 21.5 M | $187 M |
| 2022 Q1 | 49 | 21.7 M | $173 M |
| 2021 Q4 | 57 | 25.6 M | $343 M |
| 2021 Q3 | 54 | 22.5 M | $292 M |
| 2021 Q2 | 53 | 23.5 M | $272 M |
| 2021 Q1 | 46 | 23.7 M | $266 M |
| 2020 Q4 | 42 | 20.0 M | $216 M |
| 2020 Q3 | 44 | 18.8 M | $199 M |