Investors who own more than 5% of a class must file a Schedule 13D or 13G. Every filing for 877619106 since 12/18/2024, newest first.
| Filer | % of Class | Filed | |
|---|---|---|---|
|
RA Capital Management, L.P.
13G/A
Amendment 5
|
9.9% |
8/14/2026
Event 6/30/2026
|
|
| RA Capital Management, L.P. | 9.9% | ||
| Peter Kolchinsky | 9.9% | ||
| Rajeev Shah | 9.9% | ||
| RA Capital Healthcare Fund, L.P. | 9.9% | ||
|
Morgan Stanley
13G/A
Amendment 2
|
5.1% |
8/13/2026
Event 6/30/2026
|
|
| Morgan Stanley | 5.1% | ||
| Morgan Stanley Capital Services LLC | 5.0% | ||
|
RTW Investments, LP
13G/A
Amendment 5
|
7.0% |
5/15/2026
Event 3/31/2026
|
|
| RTW Investments, LP | 7.0% | ||
| Roderick Wong | 7.0% | ||
|
Vestal Point Capital, LP
13G/A
Amendment 1
|
6.3% |
5/15/2026
Event 3/31/2026
|
|
| Vestal Point Capital, LP | 6.3% | ||
| Ryan Wilder | 6.3% | ||
|
RTW Investments, LP
13G/A
Amendment 4
|
8.3% |
2/17/2026
Event 12/31/2025
|
|
| RTW Investments, LP | 8.3% | ||
| Roderick Wong | 8.3% | ||
|
Vestal Point Capital, LP
13G
|
5.0% |
2/17/2026
Event 12/31/2025
|
|
| Vestal Point Capital, LP | 5.0% | ||
| Ryan Wilder | 5.0% | ||
|
FMR LLC
13G/A
Amendment 10
|
4.9% |
2/5/2026
Event 12/31/2025
|
|
| FMR LLC | 4.9% | ||
| Abigail P. Johnson | 4.9% | ||
| BlackRock, Inc. 13G/A Amendment 2 | 6.5% |
1/21/2026
Event 12/31/2025
|
|
|
RA Capital Management, L.P.
13G/A
Amendment 4
|
9.9% |
11/14/2025
Event 9/30/2025
|
|
| RA Capital Management, L.P. | 9.9% | ||
| Peter Kolchinsky | 9.9% | ||
| Rajeev Shah | 9.9% | ||
| RA Capital Healthcare Fund, L.P. | 9.9% | ||
|
Octagon Capital Advisors LP
13G/A
Amendment 1
|
3.3% |
11/14/2025
Event 9/30/2025
|
|
| Octagon Capital Advisors LP | 3.3% | ||
| Octagon Investments Master Fund | 3.3% | ||
| Ting Jia | 3.3% | ||
|
RA Capital Management, L.P.
13G/A
Amendment 3
|
9.9% |
8/14/2025
Event 6/30/2025
|
|
| RA Capital Management, L.P. | 9.9% | ||
| Peter Kolchinsky | 9.9% | ||
| Rajeev Shah | 9.9% | ||
| RA Capital Healthcare Fund, L.P. | 9.9% | ||
|
RTW Investments, LP
13G/A
Amendment 3
|
9.9% |
8/14/2025
Event 6/30/2025
|
|
| RTW Investments, LP | 9.9% | ||
| Roderick Wong | 9.9% | ||
|
Morgan Stanley
13G/A
Amendment 1
|
6.7% |
8/6/2025
Event 6/30/2025
|
|
| Morgan Stanley | 6.7% | ||
| Morgan Stanley Capital Services LLC | 5.6% | ||
|
FMR LLC
13G/A
Amendment 9
|
6.2% |
8/6/2025
Event 6/30/2025
|
|
| FMR LLC | 6.2% | ||
| Abigail P. Johnson | 6.2% | ||
| BlackRock, Inc. 13G/A Amendment 1 | 5.2% |
7/16/2025
Event 6/30/2025
|
|
|
Goldman Sachs Group Inc
13G
|
5.1% |
7/3/2025
Event 6/26/2025
|
|
| The Goldman Sachs Group, Inc. | 5.1% | ||
| Goldman Sachs & Co. LLC | 5.1% | ||
|
Paul B Manning
13D/A
Amendment 3
|
9.8% |
6/3/2025
Event 5/30/2025
|
|
| Paul B Manning | 9.8% | ||
| The Paul B. Manning Revocable Trust dated May 10, 2000 | 5.6% | ||
| The PBM 2023 Grantor Retained Annuity Trust | 1.5% | ||
| The PBM 2025 Grantor Retained Annuity Trust | 1.5% | ||
| BKB Growth Investments, LLC | 1.1% | ||
| BKB G2 Investments, LLC | 0% | ||
|
RTW Investments, LP
13G/A
Amendment 2
|
10.0% |
5/15/2025
Event 3/31/2025
|
|
| RTW Investments, LP | 10.0% | ||
| Roderick Wong, M.D. | 10.0% | ||
|
RTW Investments, LP
13G/A
Amendment 1
|
5.9% |
2/14/2025
Event 12/31/2024
|
|
| RTW Investments, LP | 5.9% | ||
| Roderick Wong, M.D. | 5.9% | ||
|
FMR LLC
13G/A
Amendment 8
|
8.0% |
2/12/2025
Event 12/31/2024
|
|
| FMR LLC | 8.0% | ||
| Abigail P. Johnson | 8.0% | ||
|
Octagon Capital Advisors LP
13G
|
5.1% |
2/5/2025
Event 12/31/2024
|
|
| Octagon Capital Advisors LP | 5.1% | ||
| Octagon Investments Master Fund | 5.1% | ||
| Ting Jia | 5.1% | ||
|
Morgan Stanley
13G
|
8.6% |
2/5/2025
Event 12/31/2024
|
|
| Morgan Stanley | 8.6% | ||
| Morgan Stanley Capital Services LLC | 7.0% |
| Period | Filings | Shares, Excl. Options | Value, Excl. Options |
|---|---|---|---|
| 2026 Q3 | 3 | 45.9 k | $223 k |
| 2026 Q2 | 217 | 301 M | $2.23 B |
| 2026 Q1 | 202 | 266 M | $1.21 B |
| 2025 Q4 | 210 | 269 M | $1.48 B |
| 2025 Q3 | 164 | 265 M | $867 M |
| 2025 Q2 | 156 | 263 M | $609 M |
| 2025 Q1 | 132 | 167 M | $232 M |
| 2024 Q4 | 136 | 167 M | $290 M |
| 2024 Q3 | 126 | 160 M | $326 M |
| 2024 Q2 | 114 | 169 M | $378 M |
| 2024 Q1 | 118 | 151 M | $432 M |
| 2023 Q4 | 96 | 130 M | $231 M |
| 2023 Q3 | 69 | 130 M | $411 M |
| 2023 Q2 | 42 | 13.7 M | $9.05 M |
| 2023 Q1 | 47 | 16.7 M | $13.3 M |
| 2022 Q4 | 57 | 19.5 M | $44.0 M |
| 2022 Q3 | 57 | 13.9 M | $27.0 M |
| 2022 Q2 | 61 | 14.7 M | $54.7 M |
| 2022 Q1 | 75 | 17.0 M | $111 M |
| 2021 Q4 | 66 | 18.5 M | $216 M |
| 2021 Q3 | 49 | 19.4 M | $362 M |
| 2021 Q2 | 51 | 18.6 M | $395 M |
| 2021 Q1 | 49 | 18.1 M | $368 M |
| 2020 Q4 | 53 | 18.0 M | $475 M |
| 2020 Q3 | 47 | 16.6 M | $367 M |