SPRUCE BIOSCIENCES INC

Historical 13F Holders

Symbol: SPRB
CUSIP: 85209E208
All holders as of: Q2 2026
Type: Equity
Class: COM NEW

Reported Value, Excluding Options

Total Filings

13D/G Filers

Investors who own more than 5% of a class must file a Schedule 13D or 13G. Every filing for 85209E208 since 12/18/2024, newest first.

Filer	% of Class	Shares	Form	Filed
AWM Investment Company, Inc. 13G	5.1%	146,988	13G	8/14/2026 Event 6/30/2026
ADAR1 Capital Management, LLC 13G/A Amendment 1	2.5%	67,717	13G/A Amendment 1	8/14/2026 Event 6/30/2026
ADAR1 Capital Management, LLC	2.5%	67,717
Daniel Schneeberger	2.5%	67,717
Citadel Advisors LLC 13G/A Amendment 3	1.9%	51,919	13G/A Amendment 3	8/14/2026 Event 6/30/2026
Citadel Advisors LLC	1.7%	46,960
Citadel Advisors Holdings LP	1.7%	46,960
Citadel GP LLC	1.7%	46,960
Citadel Securities LLC	0.1%	1,684
Citadel Securities Group LP	0.2%	4,959
Citadel Securities GP LLC	0.2%	4,959
Kenneth Griffin	1.9%	51,919
OrbiMed Advisors LLC 13G	4.8%	132,200	13G	8/14/2026 Event 6/30/2026
OrbiMed Advisors LLC	4.8%	132,200
OrbiMed Capital LLC	2.5%	67,800
Integrated Core Strategies (US) LLC 13G/A Amendment 1	5.8% Checked 5% or less	160,981	13G/A Amendment 1	8/4/2026 Event 6/30/2026
Integrated Core Strategies (US) LLC	5.8%	160,981
Millennium Management LLC	5.8%	160,981
Millennium Group Management LLC	5.8%	160,981
Israel A. Englander	5.8%	160,981
BlackRock, Inc. 13G	6.8%	187,836	13G	7/30/2026 Event 6/30/2026
Orin Hirschman 13G	9.1%	250,000	13G	7/27/2026 Event 6/30/2026
Orin Hirschman	9.1%	250,000
AIGH Capital Management LLC	9.1%	250,000
Squadron Capital Management LLC 13G/A Amendment 2	0.9%	12,200	13G/A Amendment 2	5/15/2026 Event 3/31/2026
Squadron Master Fund LP	0.9%	12,200
Squadron Capital Management LLC	0.9%	12,200
Matthew Sesterhenn	0.9%	12,200
William Blank	0.9%	12,200
Alyeska Investment Group, L.P. 13G/A Amendment 1	4.5%	61,670	13G/A Amendment 1	5/15/2026 Event 3/31/2026
Alyeska Investment Group, L.P.	4.5%	61,670
Alyeska Fund GP, LLC	4.5%	61,670
Anand Parekh	4.5%	61,670
Citadel Advisors LLC 13G/A Amendment 2	5.1%	70,065	13G/A Amendment 2	5/15/2026 Event 3/31/2026
Citadel Advisors LLC	5.1%	69,999
Citadel Advisors Holdings LP	5.1%	69,999
Citadel GP LLC	5.1%	69,999
Citadel Securities LLC	0%	66
Citadel Securities Group LP	0%	66
Citadel Securities GP LLC	0%	66
Kenneth Griffin	5.1%	70,065
Wellington Management Group LLP 13G/A Amendment 1	3.6%	48,796	13G/A Amendment 1	5/15/2026 Event 3/31/2026
Wellington Management Group LLP	3.6%	48,796
Wellington Group Holdings LLP	3.6%	48,796
Wellington Investment Advisors Holdings LLP	3.6%	48,796
Ikarian Capital, LLC 13G/A Amendment 2	4.8%	121,356	13G/A Amendment 2	5/7/2026 Event 4/30/2026
Ikarian Capital, LLC	4.8%	121,356
Neil Shahrestani	4.8%	121,356
ExodusPoint Capital Management, LP 13G	0.8%	22,000	13G	4/28/2026 Event 4/22/2026
ExodusPoint Capital Management, LP	0.8%	22,000
ExodusPoint Capital Partners GP, LLC	0.8%	22,000
Michael Gelband	0.8%	22,000
Integrated Core Strategies (US) LLC 13G	9.6%	103,026	13G	2/24/2026 Event 2/17/2026
Integrated Core Strategies (US) LLC	9.6%	102,971
Millennium Management LLC	9.6%	103,026
Millennium Group Management LLC	9.6%	103,026
Israel A. Englander	9.6%	103,026
Carlyle Group Inc. 13D/A Amendment 3	4.7%	50,893	13D/A Amendment 3	2/18/2026 Event 2/18/2026
The Carlyle Group Inc.	4.7%	50,893
Carlyle Holdings I GP Inc.	4.7%	50,893
Carlyle Holdings I GP Sub L.L.C.	4.7%	50,893
Carlyle Holdings I L.P.	4.7%	50,893
CG Subsidiary Holdings L.L.C.	4.7%	50,893
TC Group, L.L.C.	4.7%	50,893
Carlyle Investment Management L.L.C.	4.7%	50,893
Carlyle Genesis UK LLC	4.7%	50,893
Abingworth LLP	4.7%	50,893
Abingworth Bioventures VII LP	4.7%	50,893
Squadron Capital Management LLC 13G/A Amendment 1	6.5%	70,000	13G/A Amendment 1	2/17/2026 Event 12/31/2025
Squadron Master Fund LP	6.5%	70,000
Squadron Capital Management LLC	6.5%	70,000
Matthew Sesterhenn	6.5%	70,000
William Blank	6.5%	70,000
Alyeska Investment Group, L.P. 13G	5.8%	61,670	13G	2/17/2026 Event 12/31/2025
Alyeska Investment Group, L.P.	5.8%	61,670
Alyeska Fund GP, LLC	5.8%	61,670
Anand Parekh	5.8%	61,670
ADAR1 Capital Management, LLC 13G	5.4%	58,000	13G	2/17/2026 Event 12/31/2025
ADAR1 Capital Management, LLC	5.4%	58,000
Daniel Schneeberger	5.4%	58,000
Citadel Advisors LLC 13G/A Amendment 1	6.5%	70,035	13G/A Amendment 1	2/17/2026 Event 12/31/2025
Citadel Advisors LLC	6.5%	69,999
Citadel Advisors Holdings LP	6.5%	69,999
Citadel GP LLC	6.5%	69,999
Citadel Securities LLC	0%	36
Citadel Securities Group LP	0%	36
Citadel Securities GP LLC	0%	36
Kenneth Griffin	6.5%	70,035
Wellington Management Group LLP 13G	5.5%	58,949	13G	2/10/2026 Event 12/31/2025
Wellington Management Group LLP	5.5%	58,949
Wellington Group Holdings LLP	5.5%	58,949
Wellington Investment Advisors Holdings LLP	5.5%	58,949
Boone Peter David Mr 13G	6.4%	68,184	13G	11/24/2025 Event 11/21/2025
Ikarian Capital, LLC 13G/A Amendment 1	11.4%	121,356	13G/A Amendment 1	11/7/2025 Event 10/31/2025
Ikarian Capital, LLC	11.4%	121,356
Neil Shahrestani	11.4%	121,356
Citadel Advisors LLC 13G	10.0%	109,649	13G	10/16/2025 Event 10/9/2025
Citadel Advisors LLC	10.0%	109,649
Citadel Advisors Holdings LP	10.0%	109,649
Citadel GP LLC	10.0%	109,649
Citadel Securities LLC	0%	0
Citadel Securities Group LP	0%	0
Citadel Securities GP LLC	0%	0
Kenneth Griffin	10.0%	109,649
Squadron Capital Management LLC 13G	6.6%	70,000	13G	10/15/2025 Event 10/8/2025
Squadron Master Fund LP	5.8%	62,000
Squadron Capital Management LLC	6.6%	70,000
Matthew Sesterhenn	6.6%	70,000
William Blank	6.6%	70,000
HealthCap VIII, L.P. 13D/A Amendment 3	3.4%	36,640	13D/A Amendment 3	10/9/2025 Event 10/7/2025
HealthCap VIII, L.P.	3.4%	36,640
HealthCap VIII GP LLC	3.4%	36,640
Ikarian Capital, LLC 13G	21.6%	121,356	13G	10/8/2025 Event 10/6/2025
Ikarian Capital, LLC	21.6%	121,356
Neil Shahrestani	21.6%	121,356

13F Holders by Quarter

Period	Filings	Shares, Excl. Options	Value, Excl. Options	Options Value
2026 Q3	2	86.0	$4.18 k	$0
2026 Q2	64	2.01 M	$108 M	$0
2026 Q1	33	746 k	$48.8 M	$0
2025 Q4	32	754 k	$65.6 M	$0
2025 Q3	9	2.94 M	$25.1 M	$0