Investors who own more than 5% of a class must file a Schedule 13D or 13G. Every filing for 05370A108 since 12/18/2024, newest first.
| Filer | % of Class | Filed | |
|---|---|---|---|
|
RA Capital Management, L.P.
13G/A
Amendment 3
|
0% |
5/15/2026
Event 3/31/2026
|
|
| RA Capital Management, L.P. | 0% | ||
| Peter Kolchinsky | 0% | ||
| Rajeev Shah | 0% | ||
| RA Capital Healthcare Fund, L.P. | 0% | ||
| Janus Henderson Group PLC 13G/A Amendment 4 | 4.6% |
2/17/2026
Event 12/31/2025
|
|
|
Avoro Capital Advisors LLC
13G/A
Amendment 1
|
5.5% |
2/17/2026
Event 12/31/2025
|
|
| Avoro Capital Advisors LLC | 5.5% | ||
| Behzad Aghazadeh | 5.5% | ||
| Price T Rowe Associates Inc /MD/ 13G/A Amendment 8 | 0.1% |
2/17/2026
Event 12/31/2025
|
|
|
Wellington Management Group LLP
13G/A
Amendment 2
|
0.5% |
2/10/2026
Event 12/31/2025
|
|
| Wellington Management Group LLP | 0.5% | ||
| Wellington Group Holdings LLP | 0.5% | ||
| Wellington Investment Advisors Holdings LLP | 0.5% | ||
| Janus Henderson Group PLC 13G/A Amendment 4 | 5.5% |
12/5/2025
Event 11/28/2025
|
|
| Janus Henderson Group PLC 13G/A Amendment 3 | 10.7% |
11/14/2025
Event 9/30/2025
|
|
|
RA Capital Management, L.P.
13G/A
Amendment 2
|
5.9% |
11/14/2025
Event 9/30/2025
|
|
| RA Capital Management, L.P. | 5.9% | ||
| Peter Kolchinsky | 5.9% | ||
| Rajeev Shah | 5.9% | ||
| RA Capital Healthcare Fund, L.P. | 5.9% | ||
| Price T Rowe Associates Inc /MD/ 13G/A Amendment 7 | 7.1% |
11/14/2025
Event 9/30/2025
|
|
|
FMR LLC
13G/A
Amendment 9
|
2.1% |
11/7/2025
Event 10/31/2025
|
|
| FMR LLC | 2.1% | ||
| Abigail P. Johnson | 2.1% | ||
|
FMR LLC
13G/A
Amendment 8
|
15.0% |
11/5/2025
Event 9/30/2025
|
|
| FMR LLC | 15.0% | ||
| Abigail P. Johnson | 15.0% | ||
| Vanguard Group Inc 13G/A Amendment 3 | 9.6% |
10/30/2025
Event 9/30/2025
|
|
|
RTW Investments, LP
13D/A
Amendment 5
|
3.1% |
10/29/2025
Event 10/27/2025
|
|
| RTW Investments, LP | 3.1% | ||
| Roderick Wong | 3.1% | ||
| BlackRock, Inc. 13G/A Amendment 5 | 6.4% |
10/17/2025
Event 9/30/2025
|
|
| Janus Henderson Group PLC 13G/A Amendment 2 | 10.1% |
8/7/2025
Event 7/31/2025
|
|
| Janus Henderson Group PLC 13G/A Amendment 1 | 9.5% |
5/14/2025
Event 3/31/2025
|
|
|
Wellington Management Group LLP
13G/A
Amendment 1
|
8.1% |
5/12/2025
Event 3/31/2025
|
|
| Wellington Management Group LLP | 8.1% | ||
| Wellington Group Holdings LLP | 8.1% | ||
| Wellington Investment Advisors Holdings LLP | 8.1% | ||
| Wellington Management Company LLP | 7.5% | ||
|
FMR LLC
13G/A
Amendment 7
|
13.0% |
5/12/2025
Event 3/31/2025
|
|
| FMR LLC | 13.0% | ||
| Abigail P. Johnson | 13.0% | ||
| BlackRock, Inc. 13G/A Amendment 4 | 7.5% |
4/17/2025
Event 3/31/2025
|
|
| Janus Henderson Group PLC 13G | 5.9% |
2/14/2025
Event 12/31/2024
|
| Period | Filings | Shares, Excl. Options | Value, Excl. Options |
|---|---|---|---|
| 2026 Q1 | 1 | 8.00 k | $236 k |
| 2025 Q4 | 373 | 150 M | $10.8 B |
| 2025 Q3 | 303 | 162 M | $7.05 B |
| 2025 Q2 | 220 | 140 M | $3.99 B |
| 2025 Q1 | 238 | 135 M | $4.00 B |
| 2024 Q4 | 256 | 128 M | $3.71 B |
| 2024 Q3 | 261 | 127 M | $5.82 B |
| 2024 Q2 | 208 | 114 M | $4.66 B |
| 2024 Q1 | 167 | 93.3 M | $2.38 B |
| 2023 Q4 | 152 | 78.7 M | $712 M |
| 2023 Q3 | 147 | 81.7 M | $522 M |
| 2023 Q2 | 149 | 82.4 M | $915 M |
| 2023 Q1 | 145 | 75.9 M | $1.17 B |
| 2022 Q4 | 157 | 75.2 M | $1.67 B |
| 2022 Q3 | 131 | 53.4 M | $873 M |
| 2022 Q2 | 118 | 52.1 M | $758 M |
| 2022 Q1 | 107 | 51.1 M | $1.09 B |
| 2021 Q4 | 109 | 45.5 M | $1.08 B |
| 2021 Q3 | 113 | 44.4 M | $1.09 B |
| 2021 Q2 | 98 | 35.6 M | $880 M |
| 2021 Q1 | 103 | 35.0 M | $763 M |
| 2020 Q4 | 83 | 31.0 M | $790 M |
| 2020 Q3 | 69 | 27.0 M | $755 M |
| 2020 Q2 | 53 | 25.5 M | $702 M |