Investors who own more than 5% of a class must file a Schedule 13D or 13G. Every filing for 00461U105 since 12/18/2024, newest first.
| Filer | % of Class | Filed | |
|---|---|---|---|
|
Frazier Life Sciences Public Fund, L.P.
13G
|
5.4% |
9/21/2026
Event 9/14/2026
|
|
| Frazier Life Sciences Public Fund, L.P. | 5.4% | ||
| FHMLSP, L.P. | 5.4% | ||
| FHMLSP, L.L.C. | 5.4% | ||
| Frazier Life Sciences XI, L.P. | 0.1% | ||
| FHMLS XI, L.P. | 0.1% | ||
| FHMLS XI, L.L.C. | 0.1% | ||
| Frazier Life Sciences XII, L.P. | 0.5% | ||
| FHMLS XII, L.P. | 0.5% | ||
| FHMLS XII, L.L.C. | 0.5% | ||
|
RA Capital Management, L.P.
13G/A
Amendment 1
|
9.1% |
8/14/2026
Event 6/30/2026
|
|
| RA Capital Management, L.P. | 9.1% | ||
| Peter Kolchinsky | 9.1% | ||
| Rajeev Shah | 9.1% | ||
| RA Capital Healthcare Fund, L.P. | 9.1% | ||
|
Vivo Opportunity Fund Holdings, L.P.
13G/A
Amendment 1
|
4.3% |
5/12/2026
Event 3/31/2026
|
|
| Vivo Opportunity Fund Holdings, L.P. | 4.3% | ||
| Vivo Opportunity, LLC | 4.3% | ||
| Vivo Opportunity Cayman Fund, L.P. | 0.5% | ||
| Vivo Opportunity Cayman, LLC | 0.5% | ||
| BML Investment Partners, L.P. 13G/A Amendment 5 | 9.9% |
4/27/2026
Event 4/23/2026
|
|
|
RA Capital Management, L.P.
13G
|
6.3% |
4/7/2026
Event 3/31/2026
|
|
| RA Capital Management, L.P. | 6.3% | ||
| Peter Kolchinsky | 6.3% | ||
| Rajeev Shah | 6.3% | ||
| RA Capital Healthcare Fund, L.P. | 6.3% | ||
| Vanguard Group Inc 13G/A Amendment 1 | 0% |
3/26/2026
Event 3/13/2026
|
|
|
Deep Track Capital, LP
13G
|
7.0% |
3/17/2026
Event 3/9/2026
|
|
| Deep Track Capital, LP | 7.0% | ||
| Deep Track Biotechnology Master Fund, Ltd. | 7.0% | ||
| David Kroin | 7.0% | ||
| BML Investment Partners, L.P. 13G/A Amendment 4 | 11.9% |
2/9/2026
Event 12/31/2025
|
|
| BlackRock, Inc. 13G/A Amendment 1 | 6.2% |
1/21/2026
Event 12/31/2025
|
|
|
Bonita Biotech (HK) Ltd
13G/A
Amendment 1
|
9.4% |
1/9/2026
Event 12/9/2025
|
|
| Biosion, Inc. | 9.4% | ||
| Bonita Biotech (HK) Ltd | 9.4% | ||
|
Adage Capital Management, L.P.
13G/A
Amendment 2
|
4.9% |
11/13/2025
Event 9/30/2025
|
|
| Adage Capital Management, L.P. | 4.9% | ||
| Robert Atchinson | 4.9% | ||
| Phillip Gross | 4.9% | ||
| Vanguard Group Inc 13G | 6.2% |
7/29/2025
Event 6/30/2025
|
|
|
Millennium Management LLC
13G/A
Amendment 1
|
3.5% |
7/24/2025
Event 6/30/2025
|
|
| Millennium Management LLC | 3.5% | ||
| Millennium Group Management LLC | 3.5% | ||
| Israel A. Englander | 3.5% | ||
| BlackRock, Inc. 13G | 5.1% |
7/17/2025
Event 6/30/2025
|
|
|
Rock Springs Capital Management LP
13G/A
Amendment 1
|
4.7% |
5/15/2025
Event 3/31/2025
|
|
| Rock Springs Capital Management LP | 4.7% | ||
| Rock Springs Capital LLC | 4.7% | ||
| Rock Springs Capital Master Fund LP | 0% | ||
| Mark Bussard | 4.7% | ||
| Kris Jenner | 4.7% | ||
|
Adage Capital Management, L.P.
13G/A
Amendment 1
|
7.6% |
5/12/2025
Event 3/31/2025
|
|
| Adage Capital Management, L.P. | 7.6% | ||
| Robert Atchinson | 7.6% | ||
| Phillip Gross | 7.6% | ||
|
Millennium Management LLC
13G
|
5.1% |
5/5/2025
Event 4/28/2025
|
|
| Millennium Management LLC | 5.1% | ||
| Millennium Group Management LLC | 5.1% | ||
| Israel A. Englander | 5.1% | ||
| Vanguard Group Inc 13G/A Amendment 1 | 4.6% |
4/30/2025
Event 3/31/2025
|
|
| BML Investment Partners, L.P. 13G/A Amendment 3 | 13.3% |
2/13/2025
Event 12/31/2024
|
|
|
Adage Capital Management, L.P.
13G
|
9.0% |
2/12/2025
Event 12/31/2024
|
|
| Adage Capital Management, L.P. | 9.0% | ||
| Robert Atchinson | 9.0% | ||
| Phillip Gross | 9.0% |
| Period | Filings | Shares, Excl. Options | Value, Excl. Options |
|---|---|---|---|
| 2026 Q3 | 15 | 214 k | $1.13 M |
| 2026 Q2 | 159 | 121 M | $642 M |
| 2026 Q1 | 143 | 111 M | $414 M |
| 2025 Q4 | 125 | 83.7 M | $252 M |
| 2025 Q3 | 105 | 86.4 M | $164 M |
| 2025 Q2 | 98 | 94.7 M | $134 M |
| 2025 Q1 | 113 | 92.7 M | $144 M |
| 2024 Q4 | 106 | 87.5 M | $217 M |
| 2024 Q3 | 86 | 50.9 M | $58.6 M |
| 2024 Q2 | 104 | 53.1 M | $58.4 M |
| 2024 Q1 | 107 | 55.5 M | $69.1 M |
| 2023 Q4 | 116 | 60.1 M | $63.1 M |
| 2023 Q3 | 165 | 70.6 M | $483 M |
| 2023 Q2 | 153 | 71.5 M | $741 M |
| 2023 Q1 | 177 | 71.7 M | $580 M |
| 2022 Q4 | 136 | 67.2 M | $1.06 B |
| 2022 Q3 | 133 | 64.1 M | $1.01 B |
| 2022 Q2 | 118 | 63.3 M | $883 M |
| 2022 Q1 | 114 | 59.3 M | $1.02 B |
| 2021 Q4 | 140 | 57.0 M | $828 M |
| 2021 Q3 | 132 | 56.8 M | $1.02 B |
| 2021 Q2 | 140 | 56.9 M | $998 M |
| 2021 Q1 | 110 | 46.1 M | $1.31 B |
| 2020 Q4 | 93 | 32.1 M | $207 M |
| 2020 Q3 | 61 | 25.6 M | $65.7 M |
| 2020 Q2 | 64 | 28.7 M | $46.4 M |
| 2020 Q1 | 74 | 32.1 M | $33.4 M |
| 2019 Q4 | 83 | 31.4 M | $59.3 M |
| 2019 Q3 | 84 | 29.1 M | $31.4 M |
| 2019 Q2 | 93 | 36.0 M | $78.8 M |
| 2019 Q1 | 101 | 37.9 M | $227 M |
| 2018 Q4 | 102 | 39.5 M | $292 M |
| 2018 Q3 | 91 | 30.6 M | $444 M |
| 2018 Q2 | 102 | 32.8 M | $654 M |
| 2018 Q1 | 102 | 30.7 M | $537 M |
| 2017 Q4 | 105 | 28.5 M | $703 M |
| 2017 Q3 | 108 | 28.5 M | $737 M |
| 2017 Q2 | 108 | 25.6 M | $695 M |
| 2017 Q1 | 115 | 23.7 M | $708 M |
| 2016 Q4 | 102 | 21.4 M | $581 M |
| 2016 Q3 | 59 | 15.5 M | $397 M |
| 2016 Q2 | 48 | 15.4 M | $284 M |
| 2016 Q1 | 34 | 14.6 M | $277 M |
| 2015 Q4 | 35 | 10.3 M | $279 M |