Investors who own more than 5% of a class must file a Schedule 13D or 13G. Every filing for 457730109 since 12/18/2024, newest first.
| Filer | % of Class | Filed | |
|---|---|---|---|
|
Soleus Capital Master Fund, L.P.
13G/A
Amendment 1
|
6.7% |
8/13/2026
Event 6/30/2026
|
|
| Soleus Capital Master Fund, L.P. | 6.7% | ||
| Soleus Capital, LLC | 6.7% | ||
| Soleus Capital Group, LLC | 6.7% | ||
| Soleus Capital Management, L.P. | 6.7% | ||
| Soleus GP, LLC | 6.7% | ||
| Guy Levy | 6.7% | ||
|
AQR Capital Management, LLC
13G
|
6.4% |
8/12/2026
Event 6/30/2026
|
|
| AQR Capital Management, LLC | 6.4% | ||
| AQR Capital Management Holdings, LLC | 6.4% | ||
| Vanguard Portfolio Management LLC 13G/A Amendment 1 | 7.4% |
7/31/2026
Event 6/30/2026
|
|
| BlackRock, Inc. 13G/A Amendment 7 | 14.4% |
7/28/2026
Event 6/30/2026
|
|
|
D. E. Shaw & Co., L.P.
13G
|
5.1% |
7/2/2026
Event 6/25/2026
|
|
| D. E. Shaw & Co., L.P. | 5.1% | ||
| David E. Shaw | 5.1% | ||
|
Soleus Capital Master Fund, L.P.
13G
|
5.1% |
5/27/2026
Event 5/26/2026
|
|
| Soleus Capital Master Fund, L.P. | 5.1% | ||
| Soleus Capital, LLC | 5.1% | ||
| Soleus Capital Group, LLC | 5.1% | ||
| Soleus Capital Management, L.P. | 5.1% | ||
| Soleus GP, LLC | 5.1% | ||
| Guy Levy | 5.1% | ||
|
Wellington Management Group LLP
13G/A
Amendment 1
|
8.8% |
5/15/2026
Event 3/31/2026
|
|
| Wellington Management Group LLP | 8.8% | ||
| Wellington Group Holdings LLP | 8.8% | ||
| Wellington Investment Advisors Holdings LLP | 8.8% | ||
| Wellington Management Company LLP | 8.6% | ||
|
James E. Flynn
13G/A
Amendment 1
|
4.5% |
5/14/2026
Event 5/14/2026
|
|
| Deerfield Mgmt, L.P. | 4.5% | ||
| Deerfield Management Company, L.P. | 4.5% | ||
| Deerfield Partners, L.P. | 4.5% | ||
| James E. Flynn | 4.5% | ||
| Vanguard Capital Management LLC 13G | 5.1% |
4/30/2026
Event 3/31/2026
|
|
| Vanguard Portfolio Management LLC 13G | 5.7% |
4/29/2026
Event 3/31/2026
|
|
| Vanguard Group Inc 13G/A Amendment 4 | 0% |
3/27/2026
Event 3/13/2026
|
|
|
Citadel Advisors LLC
13G/A
Amendment 1
|
1.8% |
2/17/2026
Event 12/31/2025
|
|
| Citadel Advisors LLC | 0.6% | ||
| Citadel Advisors Holdings LP | 0.6% | ||
| Citadel GP LLC | 0.6% | ||
| Citadel Securities LLC | 0.5% | ||
| Citadel Securities Group LP | 1.2% | ||
| Citadel Securities GP LLC | 1.2% | ||
| Kenneth Griffin | 1.8% | ||
|
Wellington Management Group LLP
13G
|
7.6% |
2/10/2026
Event 12/31/2025
|
|
| Wellington Management Group LLP | 7.6% | ||
| Wellington Group Holdings LLP | 7.6% | ||
| Wellington Investment Advisors Holdings LLP | 7.6% | ||
| Wellington Management Company LLP | 7.3% | ||
|
Dragoneer Investment Group, LLC
13G/A
Amendment 1
|
0% |
11/14/2025
Event 9/30/2025
|
|
| Marc Stad | 0% | ||
| Dragoneer Investment Group, LLC | 0% | ||
|
James E. Flynn
13G
|
5.1% |
11/13/2025
Event 11/6/2025
|
|
| Deerfield Mgmt, L.P. | 5.1% | ||
| Deerfield Management Company, L.P. | 5.1% | ||
| Deerfield Partners, L.P. | 5.1% | ||
| James E. Flynn | 5.1% | ||
| Wasatch Advisors LP 13G/A Amendment 1 | 0.5% |
11/12/2025
Event 9/30/2025
|
|
| BlackRock, Inc. 13G/A Amendment 6 | 11.3% |
10/17/2025
Event 9/30/2025
|
|
|
FMR LLC
13G/A
Amendment 4
|
2.5% |
10/7/2025
Event 9/30/2025
|
|
| FMR LLC | 2.5% | ||
| Abigail P. Johnson | 2.5% | ||
|
Citadel Advisors LLC
13G
|
5.8% |
10/6/2025
Event 9/29/2025
|
|
| Citadel Advisors LLC | 4.7% | ||
| Citadel Advisors Holdings LP | 4.7% | ||
| Citadel GP LLC | 4.7% | ||
| Citadel Securities LLC | 0.4% | ||
| Citadel Securities Group LP | 1.1% | ||
| Citadel Securities GP LLC | 1.1% | ||
| Kenneth Griffin | 5.8% | ||
|
Dragoneer Investment Group, LLC
13G
|
8.0% |
8/14/2025
Event 6/30/2025
|
|
| Marc Stad | 8.0% | ||
| Dragoneer Investment Group, LLC | 8.0% | ||
| Wasatch Advisors LP 13G | 5.1% |
5/13/2025
Event 3/31/2025
|
|
| BlackRock, Inc. 13G/A Amendment 5 | 12.6% |
4/30/2025
Event 3/31/2025
|
|
|
FMR LLC
13G/A
Amendment 3
|
8.3% |
2/12/2025
Event 12/31/2024
|
|
| FMR LLC | 8.3% | ||
| Abigail P. Johnson | 8.3% |
| Period | Filings | Shares, Excl. Options | Value, Excl. Options |
|---|---|---|---|
| 2026 Q3 | 10 | 6.67 k | $462 k |
| 2026 Q2 | 288 | 39.5 M | $1.73 B |
| 2026 Q1 | 318 | 34.9 M | $1.80 B |
| 2025 Q4 | 374 | 34.6 M | $3.19 B |
| 2025 Q3 | 345 | 31.2 M | $2.32 B |
| 2025 Q2 | 381 | 33.8 M | $4.39 B |
| 2025 Q1 | 392 | 34.4 M | $5.51 B |
| 2024 Q4 | 390 | 33.4 M | $6.20 B |
| 2024 Q3 | 388 | 34.1 M | $7.20 B |
| 2024 Q2 | 364 | 32.7 M | $4.38 B |
| 2024 Q1 | 367 | 32.7 M | $7.03 B |
| 2023 Q4 | 383 | 31.9 M | $6.48 B |
| 2023 Q3 | 399 | 28.6 M | $5.68 B |
| 2023 Q2 | 442 | 28.5 M | $9.26 B |
| 2023 Q1 | 400 | 29.3 M | $6.80 B |
| 2022 Q4 | 367 | 29.4 M | $7.39 B |
| 2022 Q3 | 332 | 28.3 M | $5.02 B |
| 2022 Q2 | 308 | 27.4 M | $5.01 B |
| 2022 Q1 | 319 | 27.0 M | $6.92 B |
| 2021 Q4 | 318 | 25.9 M | $5.96 B |
| 2021 Q3 | 271 | 25.4 M | $5.92 B |
| 2021 Q2 | 267 | 25.0 M | $4.83 B |
| 2021 Q1 | 269 | 25.2 M | $5.21 B |
| 2020 Q4 | 258 | 25.2 M | $4.73 B |
| 2020 Q3 | 226 | 26.2 M | $3.38 B |
| 2020 Q2 | 204 | 26.9 M | $2.35 B |
| 2020 Q1 | 183 | 23.9 M | $1.44 B |
| 2019 Q4 | 185 | 22.4 M | $1.66 B |
| 2019 Q3 | 168 | 21.8 M | $1.33 B |
| 2019 Q2 | 166 | 20.2 M | $1.23 B |
| 2019 Q1 | 153 | 17.8 M | $1.01 B |
| 2018 Q4 | 107 | 15.0 M | $634 M |
| 2018 Q3 | 91 | 9.33 M | $393 M |
| 2018 Q2 | 77 | 9.47 M | $338 M |