| Quarter | Holdings | Value, Excl. Options ($000) | Top Holdings | Form Type | Date Filed | Filing ID |
|---|---|---|---|---|---|---|
| Q2 2026 | 24 | 1,217,462 | SRRK, ALMS, MLYS, SEPN | 13F-HR | 8/14/2026 | 000174496726000010 |
| Q1 2026 | 22 | 1,029,103 | SRRK, MLYS, ALMS, SEPN | 13F-HR | 5/15/2026 | 000174496726000005 |
| Q4 2025 | 21 | 969,257 | SRRK, MLYS, KLRS, SEPN | 13F-HR | 2/17/2026 | 000174496726000002 |
| Q3 2025 | 27 | 765,929 | MLYS, SRRK, KLRS, SEPN | 13F-HR | 11/14/2025 | 000174496725000004 |
| Q2 2025 | 29 | 488,945 | SRRK, MLYS, SEPN, KLRS | 13F-HR | 8/14/2025 | 000141588925021908 |
| Q1 2025 | 37 | 560,807 | SRRK, KLRS, MLYS, NGNE | 13F-HR | 5/15/2025 | 000141588925013106 |
| Q4 2024 | 43 | 728,583 | SRRK, CRGX, SEPN, MLYS | 13F-HR | 2/14/2025 | 000110465925014316 |
| Q3 2024 | 42 | 520,277 | CRGX, MLYS, SRRK, NGNE | 13F-HR | 11/14/2024 | 000110465924118933 |
| Q2 2024 | 40 | 477,799 | CRGX, MLYS, SRRK, NGNE | 13F-HR | 8/14/2024 | 000110465924089652 |
| Q1 2024 | 39 | 646,373 | SRRK, CRGX, MLYS, NGNE | 13F-HR | 5/15/2024 | 000110465924061946 |
| Q4 2023 | 41 | 642,801 | SRRK, RYZB, CRGX, MLYS | 13F-HR | 2/14/2024 | 000110465924023801 |
| Q3 2023 | 41 | 326,685 | MLYS, RYZB, SRRK, SLRN | 13F-HR | 11/14/2023 | 000110465923118112 |
| Q2 2023 | 47 | 569,734 | KDNY, MLYS, SLRN, SRRK | 13F-HR | 8/14/2023 | 000110465923091467 |
| Q1 2023 | 56 | 483,843 | KDNY, MLYS, SRRK, ACLX | RESTATEMENT | 8/14/2023 | 000110465923091466 |
| Q4 2022 | 1 | 3,164 | SYRS | NEW HOLDINGS | 2/15/2023 | 000110465923022435 |
| Q4 2022 | 54 | 461,242 | KDNY, SRRK, ACLX, GRPH | 13F-HR | 2/14/2023 | 000110465923021783 |
| Q3 2022 | 56 | 428,436 | KDNY, NKTX, SRRK, GRPH | 13F-HR | 11/14/2022 | 000110465922118511 |
| Q2 2022 | 57 | 373,940 | KDNY, NKTX, SRRK, GRPH | 13F-HR | 8/15/2022 | 000110465922091195 |
| Q1 2022 | 57 | 395,488 | KDNY, GRPH, NKTX, TIL | 13F-HR | 5/16/2022 | 000110465922061327 |
| Q4 2021 | 51 | 501,995 | GRPH, KDNY, TIL, NKTX | 13F-HR | 2/14/2022 | 000110465922022413 |
| Q3 2021 | 48 | 602,408 | GRPH, NKTX, KDNY, TIL | 13F-HR | 11/15/2021 | 000110465921139230 |
| Q2 2021 | 50 | 760,817 | GRPH, NKTX, KDNY, NVAX calls | 13F-HR | 8/16/2021 | 000110465921106652 |
| Q1 2021 | 44 | 496,668 | NKTX, KDNY, FMTX, TIL | 13F-HR | 5/17/2021 | 000110465921068346 |
| Q4 2020 | 43 | 994,430 | JYAC, NKTX, KDNY, FMTX | 13F-HR | 2/17/2021 | 000110465921024479 |
| Q3 2020 | 36 | 358,514 | FMTX, NKTX, ISEE, SWTX | 13F-HR | 11/16/2020 | 000110465920125923 |
| Q2 2020 | 32 | 310,856 | FMTX, SWTX, ODTC, PRNB | 13F-HR | 8/14/2020 | 000110465920095488 |
| Q1 2020 | 28 | 173,758 | ICPT, PRNB, SWTX, ODTC | 13F-HR | 5/15/2020 | 000110465920062544 |
| Q4 2019 | 19 | 208,709 | ICPT, SWTX, ALLK, ODTC | 13F-HR | 2/18/2020 | 000110465920022343 |
| Q3 2019 | 18 | 146,925 | ICPT, ALLK, SYRS, SWTX | 13F-HR | 11/14/2019 | 000110465919064283 |
| Q2 2019 | 21 | 151,361 | ICPT, ODTC, ALLK, SYRS | 13F-HR | 8/14/2019 | 000110465919045918 |
| Q1 2019 | 18 | 127,246 | ICPT, ALLK, ODTC, PRNB | 13F-HR | 5/15/2019 | 000110465919029784 |
| Q4 2018 | 17 | 104,187 | ALLK, ICPT, PRNB, STRO | 13F-HR | 2/14/2019 | 000110465919008738 |