| 
            Q2 2025
           | 
          13 | 
          154,437 | 
          
            
              BBNX, KMTS, UPB, NUVB
            
           | 
          
            13F-HR
           | 
          8/14/2025 | 
          000095012325008066 | 
        
        
          | 
            Q1 2025
           | 
          13 | 
          169,462 | 
          
            
              Kestra Med Technologies Ltd., BCAX, Beta Bionics Inc., NUVB
            
           | 
          
            13F-HR
           | 
          5/15/2025 | 
          000095012325005509 | 
        
        
          | 
            Q4 2024
           | 
          1 | 
          33,476 | 
          
            
              UPB
            
           | 
          
            NEW HOLDINGS
           | 
          5/15/2025 | 
          000095012325005507 | 
        
        
          | 
            Q4 2024
           | 
          11 | 
          120,707 | 
          
            
              BCAX, NUVB, REPL, LXEO
            
           | 
          
            13F-HR
           | 
          2/14/2025 | 
          000095012325002355 | 
        
        
          | 
            Q3 2024
           | 
          11 | 
          160,008 | 
          
            
              Bicara Therapeutics Inc., NUVB, REPL, LXEO
            
           | 
          
            13F-HR
           | 
          11/14/2024 | 
          000095012324011486 | 
        
        
          | 
            Q2 2024
           | 
          11 | 
          134,971 | 
          
            
              NUVB, LXEO, REPL, ENGN
            
           | 
          
            13F-HR
           | 
          8/14/2024 | 
          000095012324008730 | 
        
        
          | 
            Q1 2024
           | 
          11 | 
          155,010 | 
          
            
              NUVB, LXEO, REPL, ENGN
            
           | 
          
            13F-HR
           | 
          5/14/2024 | 
          000095012324005045 | 
        
        
          | 
            Q4 2023
           | 
          14 | 
          123,436 | 
          
            
              LXEO, REPL, NUVB, enGene Holdings Inc.
            
           | 
          
            13F-HR
           | 
          2/14/2024 | 
          000095012324002504 | 
        
        
          | 
            Q3 2023
           | 
          12 | 
          108,875 | 
          
            
              REPL, NUVB, IKNA, MORF
            
           | 
          
            13F-HR
           | 
          11/14/2023 | 
          000095012323010476 | 
        
        
          | 
            Q2 2023
           | 
          12 | 
          178,485 | 
          
            
              REPL, NUVB, ALPN, MORF
            
           | 
          
            13F-HR
           | 
          8/14/2023 | 
          000095012323007696 | 
        
        
          | 
            Q1 2023
           | 
          14 | 
          153,322 | 
          
            
              REPL, NUVB, MORF, ALPN
            
           | 
          
            13F-HR
           | 
          5/15/2023 | 
          000095012323005263 | 
        
        
          | 
            Q4 2022
           | 
          16 | 
          296,715 | 
          
            
              Imago Biosciences, REPL, NUVB, MORF
            
           | 
          
            13F-HR
           | 
          2/13/2023 | 
          000095012323002007 | 
        
        
          | 
            Q3 2022
           | 
          19 | 
          273,064 | 
          
            
              REPL, Imago Biosciences, NUVB, CINC
            
           | 
          
            13F-HR
           | 
          11/14/2022 | 
          000095012322012070 | 
        
        
          | 
            Q2 2022
           | 
          21 | 
          313,294 | 
          
            
              REPL, NUVB, Imago Biosciences, MORF
            
           | 
          
            13F-HR
           | 
          8/15/2022 | 
          000095012322009090 | 
        
        
          | 
            Q1 2022
           | 
          22 | 
          488,614 | 
          
            
              NUVB, REPL, Imago Biosciences, MORF
            
           | 
          
            13F-HR
           | 
          5/13/2022 | 
          000095012322005699 | 
        
        
          | 
            Q4 2021
           | 
          22 | 
          707,272 | 
          
            
              NUVB, REPL, Imago Biosciences, MORF
            
           | 
          
            13F-HR
           | 
          2/14/2022 | 
          000095012322002360 | 
        
        
          | 
            Q3 2021
           | 
          26 | 
          891,379 | 
          
            
              NUVB, REPL, KRON, MORF
            
           | 
          
            13F-HR
           | 
          11/15/2021 | 
          000095012321015480 | 
        
        
          | 
            Q2 2021
           | 
          2 | 
          279,245 | 
          
            
              NUVB, SANA
            
           | 
          
            NEW HOLDINGS
           | 
          11/15/2021 | 
          000095012321015607 | 
        
        
          | 
            Q2 2021
           | 
          21 | 
          604,351 | 
          
            
              REPL, MORF, KRON, IKNA
            
           | 
          
            13F-HR
           | 
          8/16/2021 | 
          000095012321011084 | 
        
        
          | 
            Q1 2021
           | 
          2 | 
          323,059 | 
          
            
              NUVB, SANA
            
           | 
          
            NEW HOLDINGS
           | 
          11/15/2021 | 
          000095012321015603 | 
        
        
          | 
            Q1 2021
           | 
          22 | 
          734,164 | 
          
            
              REPL, MORF, KRON, IKNA
            
           | 
          
            13F-HR
           | 
          5/17/2021 | 
          000095012321006880 | 
        
        
          | 
            Q4 2020
           | 
          19 | 
          666,876 | 
          
            
              REPL, KRON, MORF, SPRB
            
           | 
          
            13F-HR
           | 
          2/16/2021 | 
          000095012321002713 | 
        
        
          | 
            Q3 2020
           | 
          16 | 
          369,660 | 
          
            
              REPL, MORF, GOSS, IMUX
            
           | 
          
            13F-HR
           | 
          11/16/2020 | 
          000095012320011928 | 
        
        
          | 
            Q2 2020
           | 
          15 | 
          365,744 | 
          
            
              REPL, MORF, GOSS, ARQT
            
           | 
          
            13F-HR
           | 
          8/17/2020 | 
          000095012320009147 | 
        
        
          | 
            Q1 2020
           | 
          16 | 
          241,630 | 
          
            
              REPL, MORF, GOSS, ARQT
            
           | 
          
            13F-HR
           | 
          5/14/2020 | 
          000095012320004802 | 
        
        
          | 
            Q4 2019
           | 
          14 | 
          314,167 | 
          
            
              GOSS, REPL, MORF, TBIO
            
           | 
          
            13F-HR
           | 
          2/13/2020 | 
          000095012320001796 | 
        
        
          | 
            Q3 2019
           | 
          14 | 
          324,015 | 
          
            
              GOSS, REPL, MORF, TBIO
            
           | 
          
            13F-HR
           | 
          11/13/2019 | 
          000095012319010754 | 
        
        
          | 
            Q2 2019
           | 
          15 | 
          392,079 | 
          
            
              GOSS, REPL, MORF, TBIO
            
           | 
          
            13F-HR
           | 
          8/13/2019 | 
          000095012319007724 | 
        
        
          | 
            Q1 2019
           | 
          13 | 
          311,888 | 
          
            
              GOSS, REPL, TBIO, PRTK
            
           | 
          
            NEW HOLDINGS
           | 
          5/20/2019 | 
          000095012319005615 | 
        
        
          | 
            Q1 2019
           | 
          12 | 
          161,207 | 
          
            
              REPL, TBIO, PRTK, OBSV
            
           | 
          
            13F-HR
           | 
          5/15/2019 | 
          000095012319005079 | 
        
        
          | 
            Q4 2018
           | 
          14 | 
          134,874 | 
          
            
              REPL, TBIO, KZR, PRTK
            
           | 
          
            13F-HR
           | 
          2/11/2019 | 
          000095012319001091 | 
        
        
          | 
            Q3 2018
           | 
          14 | 
          211,385 | 
          
            
              REPL, PRTK, TBIO, OBSV
            
           | 
          
            13F-HR
           | 
          11/7/2018 | 
          000095012318010593 | 
        
        
          | 
            Q2 2018
           | 
          13 | 
          135,522 | 
          
            
              TBIO, PRTK, OBSV, KZR
            
           | 
          
            13F-HR
           | 
          8/2/2018 | 
          000095012318007267 | 
        
        
          | 
            Q1 2018
           | 
          12 | 
          101,754 | 
          
            
              PRTK, SNNA, OBSV, JNCE
            
           | 
          
            13F-HR
           | 
          5/4/2018 | 
          000095012318004151 | 
        
        
          | 
            Q4 2017
           | 
          12 | 
          138,312 | 
          
            
              PRTK, JUNO, SNNA, OBSV
            
           | 
          
            13F-HR
           | 
          2/5/2018 | 
          000095012318000798 | 
        
        
          | 
            Q3 2017
           | 
          11 | 
          176,759 | 
          
            
              PRTK, JUNO, FGEN, SNNA
            
           | 
          
            13F-HR
           | 
          11/3/2017 | 
          000095012317009490 | 
        
        
          | 
            Q2 2017
           | 
          11 | 
          160,239 | 
          
            
              PRTK, JUNO, FGEN, NBRV
            
           | 
          
            13F-HR
           | 
          7/26/2017 | 
          000095012317006325 | 
        
        
          | 
            Q1 2017
           | 
          11 | 
          153,841 | 
          
            
              PRTK, JUNO, FGEN, EGLTQ
            
           | 
          
            13F-HR
           | 
          5/9/2017 | 
          000095012317004097 | 
        
        
          | 
            Q4 2016
           | 
          12 | 
          123,236 | 
          
            
              PRTK, JUNO, EGLTQ, FGEN
            
           | 
          
            13F-HR
           | 
          2/10/2017 | 
          000095012317001390 | 
        
        
          | 
            Q3 2016
           | 
          11 | 
          130,994 | 
          
            
              JUNO, PRTK, EGLTQ, FGEN
            
           | 
          
            13F-HR
           | 
          11/2/2016 | 
          000095012316021058 | 
        
        
          | 
            Q2 2016
           | 
          11 | 
          134,798 | 
          
            
              JUNO, PRTK, EGLTQ, FGEN
            
           | 
          
            13F-HR
           | 
          8/3/2016 | 
          000095012316018706 | 
        
        
          | 
            Q1 2016
           | 
          11 | 
          144,173 | 
          
            
              JUNO, PRTK, EGLTQ, FGEN
            
           | 
          
            13F-HR
           | 
          5/2/2016 | 
          000095012316016121 | 
        
        
          | 
            Q4 2015
           | 
          10 | 
          179,685 | 
          
            
              JUNO, PRTK, EGLTQ, FGEN
            
           | 
          
            13F-HR
           | 
          2/10/2016 | 
          000095012316013919 | 
        
        
          | 
            Q3 2015
           | 
          10 | 
          177,613 | 
          
            
              JUNO, PRTK, EGLTQ, FGEN
            
           | 
          
            13F-HR
           | 
          11/4/2015 | 
          000095012315010742 | 
        
        
          | 
            Q2 2015
           | 
          7 | 
          198,055 | 
          
            
              JUNO, PRTK, EGLTQ, FGEN
            
           | 
          
            13F-HR
           | 
          8/10/2015 | 
          000095012315008290 | 
        
        
          | 
            Q1 2015
           | 
          7 | 
          231,250 | 
          
            
              JUNO, PRTK, EGLTQ, FGEN
            
           | 
          
            13F-HR
           | 
          5/11/2015 | 
          000095012315005268 | 
        
        
          | 
            Q4 2014
           | 
          7 | 
          217,389 | 
          
            
              PRTK, JUNO, FGEN, EGLTQ
            
           | 
          
            13F-HR
           | 
          3/23/2015 | 
          000095012315004059 |