| 
            Q2 2025
           | 
          8 | 
          52,949 | 
          
            
              PASG, EWTX, ARVN, CRNX
            
           | 
          
            13F-HR
           | 
          8/13/2025 | 
          000095012325007852 | 
        
        
          | 
            Q1 2025
           | 
          9 | 
          44,901 | 
          
            
              EWTX, ARVN, CRNX, RLYB
            
           | 
          
            13F-HR
           | 
          5/13/2025 | 
          000095012325004966 | 
        
        
          | 
            Q4 2024
           | 
          9 | 
          74,801 | 
          
            
              ARVN, EWTX, CRNX, RLYB
            
           | 
          
            13F-HR
           | 
          2/13/2025 | 
          000095012325002058 | 
        
        
          | 
            Q3 2024
           | 
          10 | 
          97,295 | 
          
            
              EWTX, ARVN, CRNX, RLYB
            
           | 
          
            13F-HR
           | 
          11/13/2024 | 
          000095012324011274 | 
        
        
          | 
            Q2 2024
           | 
          10 | 
          82,237 | 
          
            
              ARVN, EWTX, CRNX, RLYB
            
           | 
          
            13F-HR
           | 
          8/13/2024 | 
          000095012324008255 | 
        
        
          | 
            Q1 2024
           | 
          11 | 
          114,256 | 
          
            
              ARVN, EWTX, DCPH, CRNX
            
           | 
          
            13F-HR
           | 
          5/14/2024 | 
          000095012324005071 | 
        
        
          | 
            Q4 2023
           | 
          12 | 
          124,150 | 
          
            
              ARVN, HARP, EWTX, DCPH
            
           | 
          
            13F-HR
           | 
          2/13/2024 | 
          000095012324002003 | 
        
        
          | 
            Q3 2023
           | 
          12 | 
          77,875 | 
          
            
              ARVN, DCPH, RLYB, EWTX
            
           | 
          
            13F-HR
           | 
          11/13/2023 | 
          000095012323010254 | 
        
        
          | 
            Q2 2023
           | 
          14 | 
          116,438 | 
          
            
              ARVN, RLYB, DICE, DCPH
            
           | 
          
            13F-HR
           | 
          8/10/2023 | 
          000095012323007238 | 
        
        
          | 
            Q1 2023
           | 
          17 | 
          121,016 | 
          
            
              ARVN, RLYB, DCPH, DICE
            
           | 
          
            13F-HR
           | 
          5/10/2023 | 
          000095012323004364 | 
        
        
          | 
            Q4 2022
           | 
          17 | 
          138,130 | 
          
            
              ARVN, RLYB, DCPH, EWTX
            
           | 
          
            13F-HR
           | 
          2/6/2023 | 
          000095012323000807 | 
        
        
          | 
            Q3 2022
           | 
          19 | 
          168,537 | 
          
            
              ARVN, RLYB, DCPH, EWTX
            
           | 
          
            13F-HR
           | 
          11/10/2022 | 
          000095012322011473 | 
        
        
          | 
            Q2 2022
           | 
          21 | 
          154,364 | 
          
            
              ARVN, RLYB, DCPH, EWTX
            
           | 
          
            13F-HR
           | 
          8/9/2022 | 
          000095012322008147 | 
        
        
          | 
            Q1 2022
           | 
          21 | 
          202,904 | 
          
            
              ARVN, RLYB, HARP, EWTX
            
           | 
          
            13F-HR
           | 
          5/6/2022 | 
          000095012322004719 | 
        
        
          | 
            Q4 2021
           | 
          22 | 
          276,016 | 
          
            
              ARVN, HARP, EWTX, RLYB
            
           | 
          
            13F-HR
           | 
          2/11/2022 | 
          000095012322002158 | 
        
        
          | 
            Q3 2021
           | 
          22 | 
          346,698 | 
          
            
              ARVN, DCPH, RLYB, EWTX
            
           | 
          
            13F-HR
           | 
          11/12/2021 | 
          000095012321015005 | 
        
        
          | 
            Q2 2021
           | 
          19 | 
          389,597 | 
          
            
              ARVN, CRNX, EWTX, DCPH
            
           | 
          
            13F-HR
           | 
          8/12/2021 | 
          000095012321010563 | 
        
        
          | 
            Q1 2021
           | 
          18 | 
          429,664 | 
          
            
              ARVN, HARP, DCPH, EWTX
            
           | 
          
            RESTATEMENT
           | 
          8/12/2021 | 
          000095012321010559 | 
        
        
          | 
            Q4 2020
           | 
          17 | 
          432,816 | 
          
            
              ARVN, DCPH, PASG, HARP
            
           | 
          
            13F-HR
           | 
          2/10/2021 | 
          000095012321001531 | 
        
        
          | 
            Q3 2020
           | 
          18 | 
          248,188 | 
          
            
              DCPH, ARVN, HARP, PASG
            
           | 
          
            13F-HR
           | 
          11/12/2020 | 
          000095012320011526 | 
        
        
          | 
            Q2 2020
           | 
          20 | 
          348,503 | 
          
            
              ARVN, DCPH, PASG, HARP
            
           | 
          
            13F-HR
           | 
          8/13/2020 | 
          000095012320008667 | 
        
        
          | 
            Q1 2020
           | 
          20 | 
          334,291 | 
          
            
              ARVN, DCPH, PASG, HARP
            
           | 
          
            13F-HR
           | 
          5/14/2020 | 
          000095012320004944 | 
        
        
          | 
            Q4 2019
           | 
          19 | 
          460,293 | 
          
            
              DCPH, ARVN, SIERRA ONCOLOGY INC, PRNB
            
           | 
          
            13F-HR
           | 
          2/13/2020 | 
          000095012320001663 | 
        
        
          | 
            Q3 2019
           | 
          19 | 
          330,614 | 
          
            
              DCPH, PRNB, ARVN, HARP
            
           | 
          
            13F-HR
           | 
          11/14/2019 | 
          000095012319011396 | 
        
        
          | 
            Q2 2019
           | 
          21 | 
          373,081 | 
          
            
              DCPH, PRNB, ARVN, HARP
            
           | 
          
            13F-HR
           | 
          8/13/2019 | 
          000095012319007826 | 
        
        
          | 
            Q1 2019
           | 
          20 | 
          364,942 | 
          
            
              DCPH, PRNB, ARVN, HARP
            
           | 
          
            RESTATEMENT
           | 
          6/4/2019 | 
          000095012319005820 | 
        
        
          | 
            Q4 2018
           | 
          20 | 
          364,301 | 
          
            
              DCPH, PRNB, APTX, STIM
            
           | 
          
            13F-HR
           | 
          2/13/2019 | 
          000095012319001688 | 
        
        
          | 
            Q3 2018
           | 
          20 | 
          549,556 | 
          
            
              DCPH, APTX, PRNB, STIM
            
           | 
          
            13F-HR
           | 
          11/13/2018 | 
          000095012318011341 | 
        
        
          | 
            Q2 2018
           | 
          15 | 
          414,327 | 
          
            
              DCPH, APTX, STIM, CRSP
            
           | 
          
            13F-HR
           | 
          8/14/2018 | 
          000095012318008914 | 
        
        
          | 
            Q1 2018
           | 
          14 | 
          185,189 | 
          
            
              DCPH, CRSP, WVE, OBSV
            
           | 
          
            13F-HR
           | 
          5/15/2018 | 
          000095012318005795 | 
        
        
          | 
            Q4 2017
           | 
          16 | 
          213,809 | 
          
            
              DCPH, PDSB, IRTC, WVE
            
           | 
          
            13F-HR
           | 
          2/14/2018 | 
          000095012318002471 | 
        
        
          | 
            Q3 2017
           | 
          16 | 
          215,484 | 
          
            
              DCPH, IRTC, PDSB, OXFORD IMMUNOTEC GLOBAL PLC
            
           | 
          
            13F-HR
           | 
          11/14/2017 | 
          000095012317010937 | 
        
        
          | 
            Q2 2017
           | 
          15 | 
          142,363 | 
          
            
              IRTC, ARAV, PDSB, OXFORD IMMUNOTEC GLOBAL PLC
            
           | 
          
            13F-HR
           | 
          8/14/2017 | 
          000101297517000625 | 
        
        
          | 
            Q1 2017
           | 
          16 | 
          195,197 | 
          
            
              IRTC, ARAV, PDSB, WVE
            
           | 
          
            13F-HR
           | 
          5/15/2017 | 
          000101297517000408 | 
        
        
          | 
            Q4 2016
           | 
          15 | 
          139,613 | 
          
            
              ARAV, PDSB, OXFORD IMMUNOTEC GLOBAL PLC, WVE
            
           | 
          
            13F-HR
           | 
          2/14/2017 | 
          000101297517000134 | 
        
        
          | 
            Q3 2016
           | 
          14 | 
          138,901 | 
          
            
              WVE, ARAV, PDSB, OXFORD IMMUNOTEC GLOBAL PLC
            
           | 
          
            13F-HR
           | 
          11/14/2016 | 
          000163161416000007 | 
        
        
          | 
            Q2 2016
           | 
          14 | 
          116,235 | 
          
            
              PDSB, ARAV, WVE, OXFORD IMMUNOTEC GLOBAL PLC
            
           | 
          
            13F-HR
           | 
          8/15/2016 | 
          000163161416000006 | 
        
        
          | 
            Q1 2016
           | 
          13 | 
          110,496 | 
          
            
              PDSB, ARAV, DMTX, OXFORD IMMUNOTEC GLOBAL PLC
            
           | 
          
            13F-HR
           | 
          5/16/2016 | 
          000101297516001257 | 
        
        
          | 
            Q4 2015
           | 
          10 | 
          149,381 | 
          
            
              PDSB, ARAV, DMTX, ALDR
            
           | 
          
            13F-HR
           | 
          2/16/2016 | 
          000163161416000005 | 
        
        
          | 
            Q3 2015
           | 
          13 | 
          115,286 | 
          
            
              ARAV, ALDR, OXFORD IMMUNOTEC GLOBAL PLC, DVAX
            
           | 
          
            13F-HR
           | 
          11/16/2015 | 
          000163161415000004 | 
        
        
          | 
            Q2 2015
           | 
          14 | 
          150,879 | 
          
            
              ALDR, ARAV, OXFORD IMMUNOTEC GLOBAL PLC, CMRX
            
           | 
          
            13F-HR
           | 
          8/14/2015 | 
          000163161415000003 | 
        
        
          | 
            Q1 2015
           | 
          13 | 
          147,301 | 
          
            
              ARAV, RELYPSA INC, OXFORD IMMUNOTEC GLOBAL PLC, ALDR
            
           | 
          
            13F-HR
           | 
          5/15/2015 | 
          000101297515000410 | 
        
        
          | 
            Q4 2014
           | 
          13 | 
          205,507 | 
          
            
              ARAV, RELYPSA INC, CMRX, OXFORD IMMUNOTEC GLOBAL PLC
            
           | 
          
            13F-HR
           | 
          2/17/2015 | 
          000163161415000001 |