| Quarter | Holdings | Value ($000) | Top Holdings | Form Type | Date Filed | Filing ID |
|---|---|---|---|---|---|---|
| Q4 2019 | 20 | 379,352 | TXG, AXSM, CNST, BHVN | 13F-HR | 2/13/2020 | 000095012320001878 |
| Q3 2019 | 21 | 262,408 | TXG, BHVN, ASND, SWAV | 13F-HR | 11/13/2019 | 000095012319010839 |
| Q2 2019 | 21 | 317,188 | ASND, SWAV, BHVN, OBSVF | 13F-HR | 8/13/2019 | 000095012319007806 |
| Q1 2019 | 21 | 341,753 | ASND, BHVN, TCDAQ, SWAV | 13F-HR | 5/14/2019 | 000095012319004909 |
| Q4 2018 | 19 | 232,951 | BHVN, ASND, OBSVF, BCRX | 13F-HR | 2/13/2019 | 000095012319001657 |
| Q3 2018 | 21 | 374,474 | ECYT, BHVN, OBSVF, ASND | 13F-HR | 11/13/2018 | 000095012318011328 |
| Q2 2018 | 18 | 334,079 | ECYT, BHVN, OBSVF, ASND | 13F-HR | 8/13/2018 | 000095012318008382 |
| Q1 2018 | 17 | 414,401 | AVXS, ECYT, ASND, BHVN | 13F-HR | 5/14/2018 | 000095012318005292 |
| Q4 2017 | 18 | 417,194 | AVXS, BHVN, ASND, ARGX | 13F-HR | 2/13/2018 | 000095012318001778 |
| Q3 2017 | 21 | 361,938 | AVXS, BHVN, ASND, ZGNX | 13F-HR | 11/13/2017 | 000095012317010386 |
| Q2 2017 | 19 | 250,383 | AVXS, BHVN, ASND, EDGE | 13F-HR | 8/11/2017 | 000095012317007498 |
| Q1 2017 | 20 | 244,417 | AVXS, BCRX, ASND, DBV.PA | 13F-HR | 5/12/2017 | 000095012317004811 |
| Q4 2016 | 22 | 208,495 | AVXS, BCRX, EDGE, DBV.PA | 13F-HR | 2/13/2017 | 000095012317001786 |
| Q3 2016 | 24 | 194,834 | AVXS, BCRX, EDGE, DBV.PA | 13F-HR | 11/14/2016 | 000095012316022460 |
| Q2 2016 | 23 | 165,687 | AVXS, EDGE, DBV.PA, BCRX | 13F-HR | 8/12/2016 | 000095012316019771 |
| Q1 2016 | 22 | 152,014 | AVXS, EDGE, ASND, BCRX | 13F-HR | 5/13/2016 | 000095012316017148 |
| Q4 2015 | 15 | 121,744 | EDGE, RGNX, DBV.PA, ASND | 13F-HR | 2/12/2016 | 000095012316014521 |