| Quarter | Holdings | Value ($000) | Top Holdings | Form Type | Date Filed | Filing ID |
|---|---|---|---|---|---|---|
| Q3 2022 | 4 | 32,279 | BCYC, BVS, XFOR, ASXC | 13F-HR | 11/7/2022 | 000095012322010974 |
| Q2 2022 | 5 | 43,808 | AHCO, BCYC, BVS, XFOR | 13F-HR | 8/12/2022 | 000095012322008840 |
| Q1 2022 | 5 | 82,795 | BCYC, BVS, AHCO, XFOR | 13F-HR | 5/16/2022 | 000095012322006222 |
| Q4 2021 | 6 | 154,705 | BCYC, AHCO, STRO, BVS | 13F-HR | 2/11/2022 | 000095012322002067 |
| Q3 2021 | 8 | 204,360 | BCYC, AHCO, MSON, STRO | 13F-HR | 11/15/2021 | 000095012321015268 |
| Q2 2021 | 7 | 229,564 | AHCO, BCYC, MSON, STRO | 13F-HR | 8/16/2021 | 000095012321011532 |
| Q1 2021 | 8 | 266,962 | AHCO, BCYC, STRO, MSON | 13F-HR | 5/17/2021 | 000095012321006725 |
| Q4 2020 | 9 | 207,572 | AMWL, STRO, BCYC, DCPH | 13F-HR | 2/16/2021 | 000095012321002835 |
| Q3 2020 | 10 | 197,379 | AMWL, BCYC, DCPH, KALV | 13F-HR | 11/12/2020 | 000095012320011505 |
| Q2 2020 | 10 | 144,183 | BCYC, DCPH, MSON, AVRO | 13F-HR | 8/14/2020 | 000095012320008726 |
| Q1 2020 | 10 | 119,233 | BCYC, AVRO, STRO, DCPH | 13F-HR | 5/15/2020 | 000095012320005013 |
| Q4 2019 | 10 | 165,105 | MSON, KALV, AVRO, DCPH | 13F-HR | 2/14/2020 | 000095012320002319 |
| Q3 2019 | 10 | 142,368 | MSON, BCYC, AVRO, KALV | 13F-HR | 11/14/2019 | 000095012319011421 |
| Q2 2019 | 9 | 148,982 | KALV, AVRO, STRO, DCPH | 13F-HR | 8/14/2019 | 000095012319008273 |
| Q1 2019 | 8 | 170,475 | KALV, AVRO, DCPH, STRO | 13F-HR | 5/15/2019 | 000095012319004982 |
| Q4 2018 | 9 | 162,431 | KALV, AVRO, DCPH, STRO | 13F-HR | 2/14/2019 | 000095012319002025 |
| Q3 2018 | 9 | 341,533 | AVRO, DCPH, KALV, TRXC | 13F-HR | 11/14/2018 | 000095012318011999 |
| Q2 2018 | 8 | 217,803 | AVRO, DCPH, TRXC, KALV | 13F-HR | 8/6/2018 | 000095012318007422 |
| Q1 2018 | 7 | 133,342 | ASNS, DCPH, KALV, TRXC | 13F-HR | 5/15/2018 | 000095012318005539 |
| Q4 2017 | 8 | 189,313 | ENTL, DCPH, KALV, ASNS | 13F-HR | 2/14/2018 | 000095012318002127 |
| Q3 2017 | 7 | 131,873 | ENTL, DCPH, KALV, TRXC | 13F-HR | 11/14/2017 | 000095012317010558 |
| Q2 2017 | 6 | 92,912 | ENTL, KALV, OCUL, TRXC | 13F-HR | 8/10/2017 | 000095012317007099 |
| Q1 2017 | 6 | 90,541 | ENTL, KALV, OCUL, TRXC | 13F-HR | 5/1/2017 | 000095012317003684 |
| Q4 2016 | 6 | 118,762 | ENTL, KALV, OCUL, CATB | 13F-HR | 2/7/2017 | 000095012317000924 |
| Q3 2016 | 6 | 130,196 | ENTL, CATB, OCUL, TRXC | 13F-HR | 11/14/2016 | 000095012316022022 |
| Q2 2016 | 6 | 99,043 | ENTL, CATB, OCUL, TRXC | 13F-HR | 8/12/2016 | 000095012316019508 |
| Q1 2016 | 6 | 133,836 | ENTL, TRXC, OCUL, CATB | 13F-HR | 5/13/2016 | 000095012316017019 |
| Q4 2015 | 6 | 124,393 | ENTL, CATB, TRXC, OCUL | 13F-HR | 2/16/2016 | 000095012316015098 |
| Q3 2015 | 6 | 178,808 | ENTL, OPHT, OCUL, CATB | 13F-HR | 11/16/2015 | 000095012315012108 |
| Q2 2015 | 5 | 261,191 | ENTL, OPHT, OCUL, CATB | 13F-HR | 8/12/2015 | 000095012315008669 |
| Q1 2015 | 4 | 302,636 | OCUL, OPHT, ENTL, TRXC | 13F-HR | 5/15/2015 | 000095012315006567 |
| Q4 2014 | 3 | 200,404 | OPHT, OCUL, TRXC | 13F-HR | 2/13/2015 | 000095012315001930 |
| Q3 2014 | 3 | 200,417 | OPHT, OCUL, TRXC | 13F-HR | 11/14/2014 | 000095012314012208 |
| Q2 2014 | 2 | 178,026 | OPHT, TRXC | 13F-HR | 9/10/2014 | 000095012314009678 |