| Quarter | Holdings | Value ($000) | Top Holdings | Form Type | Date Filed | Filing ID |
|---|---|---|---|---|---|---|
| Q2 2016 | 4 | 107,483 | AGIO, SELB, SESN, REGI | 13F-HR | 8/15/2016 | 000101297516001431 |
| Q4 2015 | 4 | 152,401 | AGIO, MCRB, SESN, REGI | 13F-HR | 2/12/2016 | 000101297516001004 |
| Q3 2015 | 5 | 159,073 | AGIO, MCRB, SESN, REGI | 13F-HR | 11/13/2015 | 000095012315011952 |
| Q2 2015 | 5 | 246,164 | AGIO, MCRB, SESN, BGMD | 13F-HR | 7/28/2015 | 000095012315007759 |
| Q1 2015 | 4 | 201,342 | AGIO, SESN, BGMD, REGI | 13F-HR | 4/30/2015 | 000095012315004825 |
| Q4 2014 | 4 | 240,659 | AGIO, SESN, REGI, BGMD | 13F-HR | 2/12/2015 | 000095012315001785 |
| Q3 2014 | 4 | 141,733 | AGIO, SESN, REGI, BGMD | 13F-HR | 11/4/2014 | 000095012314010907 |
| Q2 2014 | 4 | 117,096 | AGIO, SESN, BGMD, REGI | 13F-HR | 8/8/2014 | 000095012314008132 |
| Q1 2014 | 4 | 227,926 | AGIO, RCPT, SESN, BGMD | 13F-HR | 5/12/2014 | 000095012314005461 |
| Q4 2013 | 4 | 156,790 | AGIO, RCPT, TTPH, BGMD | 13F-HR | 2/10/2014 | 000095012314001419 |