| Quarter | Holdings | Value ($000) | Top Holdings | Form Type | Date Filed | Filing ID |
|---|---|---|---|---|---|---|
| Q2 2026 | 88 | 524,358 | RVMD, XBI, CMPS, STXS | 13F-HR | 8/14/2026 | 000138993326000006 |
| Q1 2026 | 83 | 439,591 | RVMD, XBI, STXS, DAWN | 13F-HR | 5/15/2026 | 000138993326000004 |
| Q4 2025 | 77 | 430,518 | RVMD, XBI, STXS, ATRC | 13F-HR | 2/17/2026 | 000138993326000002 |
| Q3 2025 | 75 | 404,785 | STXS, XBI, RVMD, CYTK | 13F-HR | 11/14/2025 | 000138993325000008 |
| Q2 2025 | 76 | 362,250 | XBI, STXS, RVMD, BPMC | 13F-HR | 8/14/2025 | 000138993225000011 |
| Q1 2025 | 83 | 352,661 | XBI, STXS, RVMD, MRUS | 13F-HR | 5/15/2025 | 000138993325000002 |
| Q4 2024 | 82 | 393,410 | XBI, STXS, RVMD, ATRC | 13F-HR | 2/14/2025 | 000138993225000004 |
| Q3 2024 | 84 | 423,312 | XBI, STXS, RVMD, CYTK | 13F-HR | 11/14/2024 | 000138993224000020 |
| Q2 2024 | 83 | 418,567 | XBI, STXS, MRUS, CYTK | 13F-HR | 8/14/2024 | 000138993224000016 |
| Q1 2024 | 72 | 439,278 | XBI, STXS, CYTK, IDYA | 13F-HR | 5/15/2024 | 000138993224000012 |
| Q4 2023 | 76 | 417,341 | XBI, CYTK, STXS, IDYA | 13F-HR | 2/14/2024 | 000138993224000004 |
| Q3 2023 | 75 | 321,489 | XBI, STXS, CYTK, IDYA | 13F-HR | 11/14/2023 | 000138993223000010 |
| Q2 2023 | 73 | 365,729 | XBI, ISEE, STXS, BPMC | 13F-HR | 8/14/2023 | 000138993323000008 |
| Q1 2023 | 72 | 333,536 | XBI, STXS, ISEE, ASND | 13F-HR | 5/15/2023 | 000138993323000006 |
| Q4 2022 | 79 | 355,054 | XBI, STXS, ASND, KRTX | 13F-HR | 2/14/2023 | 000138993323000002 |
| Q3 2022 | 87 | 371,806 | XBI, STXS, BHVN, BPMC | 13F-HR | 11/14/2022 | 000138993322000010 |
| Q2 2022 | 90 | 366,898 | XBI, STXS, BHVN, ACET | 13F-HR | 8/15/2022 | 000138993322000008 |
| Q1 2022 | 94 | 383,776 | STXS, XBI, FATE, BPMC | 13F-HR | 5/16/2022 | 000138993322000006 |
| Q4 2021 | 87 | 397,677 | STXS, BPMC, FATE, ACET | 13F-HR | 2/14/2022 | 000138993322000002 |
| Q3 2021 | 80 | 376,924 | STXS, BPMC, FATE, BHVN | 13F-HR | 11/15/2021 | 000138993321000011 |
| Q2 2021 | 84 | 478,152 | STXS, FATE, DRNA, BPMC | 13F-HR | 8/16/2021 | 000138993321000009 |
| Q1 2021 | 89 | 421,480 | STXS, FATE, BPMC, DRNA | 13F-HR | 5/17/2021 | 000138993321000007 |
| Q4 2020 | 74 | 336,078 | STXS, FATE, BPMC, SAGE | 13F-HR | 2/16/2021 | 000138993321000004 |
| Q3 2020 | 80 | 307,632 | STXS, IMMU, BPMC, FATE | 13F-HR | 11/16/2020 | 000138993320000010 |
| Q2 2020 | 87 | 346,509 | STXS, BPMC, FATE, ARNA | 13F-HR | 8/14/2020 | 000138993320000008 |
| Q1 2020 | 80 | 239,627 | STXS, BPMC, FATE, LKFT | 13F-HR | 5/15/2020 | 000138993320000006 |
| Q4 2019 | 81 | 291,332 | STXS, PRQR, ATRC, ARQL | 13F-HR | 2/14/2020 | 000138993320000004 |
| Q3 2019 | 89 | 265,897 | STXS, SAGE, ALDR, BPMC | 13F-HR | 11/14/2019 | 000138993319000010 |
| Q2 2019 | 87 | 266,028 | STXS, SAGE, BPMC, ATRC | 13F-HR | 8/14/2019 | 000138993319000008 |
| Q1 2019 | 79 | 231,803 | STXS, SAGE, BPMC, ATRC | 13F-HR | 5/15/2019 | 000138993319000006 |
| Q4 2018 | 83 | 201,092 | LOXO, STXS, SAGE, ATRC | 13F-HR | 2/14/2019 | 000138993319000002 |
| Q3 2018 | 75 | 243,521 | LOXO, STXS, SAGE, ATRC | 13F-HR | 11/14/2018 | 000138993318000012 |
| Q2 2018 | 75 | 213,579 | LOXO, SAGE, STXS, AERI | 13F-HR | 8/13/2018 | 000138993318000010 |
| Q1 2018 | 75 | 205,558 | LOXO, SAGE, STXS, BPMC | 13F-HR | 5/15/2018 | 000138993318000008 |
| Q4 2017 | 72 | 185,688 | LOXO, BPMC, ATRC, AERI | 13F-HR | 2/14/2018 | 000138993318000002 |
| Q3 2017 | 73 | 161,052 | LOXO, ATRC, ONC, IMMU | 13F-HR | 11/14/2017 | 000138993317000025 |
| Q2 2017 | 75 | 140,138 | LOXO, ATRC, IMMU, AERI | 13F-HR | 8/14/2017 | 000138993317000023 |
| Q1 2017 | 72 | 118,230 | LOXO, ATRC, NXTM, ALDR | 13F-HR | 5/15/2017 | 000138993317000018 |
| Q4 2016 | 66 | 113,823 | ATRC, NXTM, ALDR, LOXO | 13F-HR | 2/14/2017 | 000138993317000014 |
| Q3 2016 | 74 | 143,580 | VTAE, CYNA, ATRC, NXTM | 13F-HR | 11/14/2016 | 000138993316000037 |
| Q2 2016 | 94 | 126,173 | NXTM, ATRC, VTAE, DERM | 13F-HR | 8/15/2016 | 000138993316000031 |
| Q1 2016 | 93 | 115,926 | ATRC, ABBV, NXTM, VTAE | 13F-HR | 5/16/2016 | 000138993316000029 |
| Q4 2015 | 77 | 112,179 | ATRC, NXTM, ABBV, MRNS | 13F-HR | 2/12/2016 | 000138993316000022 |
| Q3 2015 | 88 | 100,779 | ATRC, ABBV, NXTM, ZSPH | 13F-HR | 11/13/2015 | 000138993315000019 |
| Q2 2015 | 75 | 118,236 | ATRC, ABBV, NXTM, ACHN | 13F-HR | 8/14/2015 | 000138993315000016 |
| Q1 2015 | 71 | 130,246 | PCYC, ATRC, ASPX, NXTM | 13F-HR | 5/15/2015 | 000138993315000013 |
| Q4 2014 | 62 | 126,410 | PCYC, ATRC, ASPX, NXTM | 13F-HR | 2/17/2015 | 000138993315000009 |
| Q3 2014 | 59 | 99,148 | PCYC, DSCO, ATRC, NXTM | 13F-HR | 11/14/2014 | 000138993314000012 |
| Q2 2014 | 49 | 105,516 | AMPE, ATRC, PCYC, DSCO | 13F-HR | 8/14/2014 | 000138993314000010 |
| Q1 2014 | 46 | 116,350 | DSCO, PCYC, ATRC, AMPE | 13F-HR | 5/15/2014 | 000138993314000008 |
| Q4 2013 | 47 | 97,156 | DSCO, PCYC, ATRC, STXS | 13F-HR | 2/14/2014 | 000138993314000001 |