| Quarter | Holdings | Value ($000) | Top Holdings | Form Type | Date Filed | Filing ID |
|---|---|---|---|---|---|---|
| Q3 2024 | 4 | 48,149 | EXEL, ESPR, INDA, EPI | 13F-HR | 10/7/2024 | 000106299324017446 |
| Q2 2024 | 4 | 54,063 | EXEL, ESPR, INDA, EPI | 13F-HR | 7/22/2024 | 000106299324013981 |
| Q1 2024 | 4 | 68,048 | EXEL, ESPR, INDA, EPI | 13F-HR | 4/11/2024 | 000106299324008287 |
| Q4 2023 | 4 | 80,018 | EXEL, ESPR, INDA, EPI | 13F-HR | 1/4/2024 | 000106299324000348 |
| Q3 2023 | 4 | 77,143 | EXEL, ESPR, INDA, EPI | 13F-HR | 10/31/2023 | 000106299323019868 |
| Q2 2023 | 4 | 115,193 | EXEL, ESPR, INDA, EPI | 13F-HR | 7/25/2023 | 000106299323015279 |
| Q1 2023 | 4 | 125,546 | EXEL, ESPR, EPI, INDA | 13F-HR | 4/10/2023 | 000106299323008989 |
| Q4 2022 | 4 | 147,901 | EXEL, ESPR, INDA, EPI | 13F-HR | 1/4/2023 | 000106299323000396 |
| Q3 2022 | 4 | 150,330 | EXEL, ESPR, INDA, EPI | 13F-HR | 11/7/2022 | 000106299322021639 |
| Q2 2022 | 4 | 202,238 | EXEL, ESPR, INDA, EPI | 13F-HR | 7/18/2022 | 000106299322016432 |
| Q1 2022 | 4 | 239,737 | EXEL, ESPR, EPI, INDA | 13F-HR | 4/12/2022 | 000106299322010083 |
| Q4 2021 | 4 | 221,352 | EXEL, ESPR, INDA, EPI | 13F-HR | 1/5/2022 | 000106299322000538 |
| Q3 2021 | 4 | 291,116 | EXEL, ESPR, INDA, EPI | 13F-HR | 10/14/2021 | 000106299321009522 |
| Q2 2021 | 4 | 282,629 | EXEL, ESPR, INDA, EPI | 13F-HR | 7/12/2021 | 000106299321006453 |
| Q1 2021 | 4 | 355,996 | EXEL, ESPR, INDA, EPI | 13F-HR | 4/9/2021 | 000106299321003524 |
| Q4 2020 | 5 | 359,367 | EXEL, ESPR, INDA, ALKS | 13F-HR | 1/6/2021 | 000106299321000151 |
| Q3 2020 | 5 | 446,296 | EXEL, ESPR, ALKS, INDA | 13F-HR | 10/19/2020 | 000106299320004995 |
| Q2 2020 | 6 | 476,775 | EXEL, ESPR, ALKS, INDA | 13F-HR | 7/14/2020 | 000106299320003298 |
| Q1 2020 | 6 | 290,383 | EXEL, ESPR, ALKS, INDA | 13F-HR | 4/30/2020 | 000106299320002033 |
| Q4 2019 | 6 | 350,575 | EXEL, ESPR, ALKS, INDA | 13F-HR | 1/2/2020 | 000106299320000008 |
| Q3 2019 | 9 | 410,559 | EXEL, ESPR, ALKS, INDA | 13F-HR | 10/31/2019 | 000106299319004099 |
| Q2 2019 | 9 | 497,155 | EXEL, ESPR, ALKS, INDA | 13F-HR | 7/24/2019 | 000106299319003007 |
| Q1 2019 | 9 | 533,329 | EXEL, ESPR, ALKS, INDA | 13F-HR | 4/3/2019 | 000106299319001555 |
| Q4 2018 | 6 | 485,472 | EXEL, ESPR, ALKS, INDA | 13F-HR | 1/2/2019 | 000106299319000005 |
| Q3 2018 | 6 | 465,250 | EXEL, ESPR, ALKS, EPI | 13F-HR | 10/9/2018 | 000106299318004007 |
| Q2 2018 | 6 | 511,974 | EXEL, ESPR, ALKS, EPI | 13F-HR | 7/19/2018 | 000106299318002967 |
| Q1 2018 | 6 | 635,754 | EXEL, ESPR, ALKS, CLDX | 13F-HR | 4/20/2018 | 000106299318001742 |
| Q4 2017 | 8 | 776,915 | EXEL, ESPR, ALKS, CLDX | 13F-HR | 1/3/2018 | 000106299318000012 |
| Q3 2017 | 8 | 658,730 | EXEL, ESPR, ALKS, CLDX | 13F-HR | 10/17/2017 | 000106299317004490 |
| Q2 2017 | 8 | 664,599 | EXEL, ALKS, ESPR, SPXU | 13F-HR | 7/21/2017 | 000106299317003341 |
| Q1 2017 | 7 | 559,323 | EXEL, ALKS, SPXU, SDS | 13F-HR | 4/24/2017 | 000106299317002016 |
| Q4 2016 | 5 | 405,188 | EXEL, ALKS, EPI, INDA | 13F-HR | 2/1/2017 | 000106299317000471 |
| Q3 2016 | 5 | 361,173 | EXEL, ALKS, EPI, INDA | 13F-HR | 10/27/2016 | 000106299316011882 |
| Q2 2016 | 5 | 245,633 | EXEL, ALKS, EPI, INDA | 13F-HR | 7/22/2016 | 000106299316010674 |
| Q1 2016 | 3 | 126,079 | EXEL, ALKS, VVUSQ | 13F-HR | 4/18/2016 | 000106299316009062 |
| Q4 2015 | 4 | 209,455 | EXEL, ALKS, VVUSQ, RCKT | 13F-HR | 1/22/2016 | 000106299316007214 |
| Q3 2015 | 4 | 189,626 | EXEL, ALKS, VVUSQ, RCKT | 13F-HR | 10/8/2015 | 000106299315005337 |
| Q2 2015 | 3 | 145,013 | EXEL, ALKS, VVUSQ | 13F-HR | 7/22/2015 | 000106299315003981 |
| Q1 2015 | 3 | 119,143 | ALKS, EXEL, VVUSQ | 13F-HR | 4/13/2015 | 000106299315001893 |
| Q4 2014 | 3 | 96,356 | ALKS, EXEL, VVUSQ | 13F-HR | 2/9/2015 | 000106299315000553 |
| Q3 2014 | 3 | 86,190 | ALKS, EXEL, VVUSQ | 13F-HR | 10/22/2014 | 000106299314006085 |
| Q2 2014 | 3 | 133,430 | EXEL, ALKS, VVUSQ | 13F-HR | 7/8/2014 | 000106299314004068 |
| Q1 2014 | 3 | 127,593 | EXEL, ALKS, VVUSQ | 13F-HR | 5/8/2014 | 000106299314002641 |
| Q4 2013 | 3 | 135,338 | EXEL, ALKS, VVUSQ | 13F-HR | 1/21/2014 | 000138233314000005 |