| Quarter | Holdings | Value ($000) | Form Type | Date Filed | Filing ID | Name |
|---|---|---|---|---|---|---|
| Q1 2023 | 30 | 1,207,102 | 13F-HR | 5/15/2023 | 000130692323000011 | Palo Alto Investors LP |
| Q4 2022 | 29 | 1,172,888 | 13F-HR | 2/14/2023 | 000130692323000009 | Palo Alto Investors LP |
| Q3 2022 | 32 | 1,264,742 | 13F-HR | 11/14/2022 | 000130692322000016 | Palo Alto Investors LP |
| Q2 2022 | 33 | 1,147,302 | 13F-HR | 8/15/2022 | 000130692322000015 | Palo Alto Investors LP |
| Q1 2022 | 35 | 1,293,496 | 13F-HR | 5/16/2022 | 000130692322000014 | Palo Alto Investors LP |
| Q4 2021 | 37 | 1,564,771 | 13F-HR | 2/14/2022 | 000130692322000004 | Palo Alto Investors LP |
| Q3 2021 | 42 | 1,656,829 | 13F-HR | 11/15/2021 | 000130692321000026 | Palo Alto Investors LP |
| Q2 2021 | 42 | 1,814,601 | 13F-HR | 8/16/2021 | 000130692321000024 | Palo Alto Investors LP |
| Q1 2021 | 42 | 1,755,095 | 13F-HR | 5/17/2021 | 000130692321000022 | Palo Alto Investors LP |
| Q4 2020 | 41 | 1,907,616 | 13F-HR | 2/16/2021 | 000130692321000016 | Palo Alto Investors LP |
| Q3 2020 | 43 | 1,821,880 | 13F-HR | 11/16/2020 | 000130692320000017 | Palo Alto Investors LP |
| Q2 2020 | 41 | 1,665,451 | 13F-HR | 8/14/2020 | 000130692320000015 | Palo Alto Investors LP |
| Q1 2020 | 37 | 1,194,223 | 13F-HR | 5/15/2020 | 000177781320000006 | Palo Alto Investors LP |
| Q4 2019 | 37 | 1,816,265 | RESTATEMENT | 4/8/2020 | 000130692320000014 | Palo Alto Investors LP |
| Q4 2019 | 37 | 1,816,265 | 13F-HR | 2/14/2020 | 000130692320000013 | Palo Alto Investors LP |
| Q3 2019 | 37 | 1,501,359 | 13F-HR | 11/14/2019 | 000130692319000017 | Palo Alto Investors LP |
| Q2 2019 | 39 | 2,056,939 | 13F-HR | 8/14/2019 | 000130692319000015 | Palo Alto Investors LP |
| Q1 2019 | 37 | 2,396,982 | RESTATEMENT | 7/30/2019 | 000130692319000014 | Palo Alto Investors LP |
| Q1 2019 | 37 | 2,396,982 | 13F-HR | 5/15/2019 | 000130692319000012 | Palo Alto Investors LP |
| Q4 2018 | 36 | 1,878,470 | 13F-HR | 2/14/2019 | 000130692319000004 | Palo Alto Investors LP |
| Q3 2018 | 36 | 2,474,055 | 13F-HR | 11/14/2018 | 000130692318000018 | Palo Alto Investors LP |
| Q2 2018 | 36 | 2,502,471 | 13F-HR | 8/14/2018 | 000130692318000016 | Palo Alto Investors LP |
| Q1 2018 | 36 | 2,338,493 | 13F-HR | 5/15/2018 | 000130692318000014 | Palo Alto Investors LP |
| Q4 2017 | 37 | 2,321,940 | 13F-HR | 2/14/2018 | 000130692318000011 | Palo Alto Investors, LLC |
| Q3 2017 | 40 | 2,374,127 | 13F-HR | 11/14/2017 | 000130692317000025 | Palo Alto Investors, LLC |
| Q2 2017 | 38 | 2,142,085 | 13F-HR | 8/14/2017 | 000130692317000021 | Palo Alto Investors, LLC |
| Q1 2017 | 39 | 2,115,751 | 13F-HR | 5/15/2017 | 000130692317000019 | Palo Alto Investors, LLC |
| Q4 2016 | 38 | 1,752,860 | 13F-HR | 2/15/2017 | 000130692317000015 | Palo Alto Investors, LLC |
| Q3 2016 | 42 | 1,721,541 | 13F-HR | 11/14/2016 | 000130692316000052 | Palo Alto Investors, LLC |
| Q2 2016 | 45 | 1,323,917 | RESTATEMENT | 8/16/2016 | 000130692316000050 | Palo Alto Investors, LLC |
| Q2 2016 | 45 | 1,323,917 | 13F-HR | 8/15/2016 | 000130692316000049 | Palo Alto Investors, LLC |
| Q1 2016 | 44 | 1,288,268 | 13F-HR | 5/16/2016 | 000130692316000048 | Palo Alto Investors, LLC |
| Q4 2015 | 43 | 1,796,692 | 13F-HR | 2/16/2016 | 000130692316000045 | Palo Alto Investors, LLC |
| Q3 2015 | 47 | 2,079,647 | 13F-HR | 11/16/2015 | 000130692315000020 | Palo Alto Investors, LLC |
| Q2 2015 | 45 | 2,249,052 | 13F-HR | 8/14/2015 | 000130692315000019 | Palo Alto Investors, LLC |
| Q1 2015 | 46 | 2,022,768 | 13F-HR | 5/15/2015 | 000130692315000016 | Palo Alto Investors, LLC |
| Q4 2014 | 46 | 1,703,520 | 13F-HR | 2/17/2015 | 000130692315000001 | Palo Alto Investors, LLC |
| Q3 2014 | 43 | 1,338,499 | 13F-HR | 11/13/2014 | 000130692314000010 | Palo Alto Investors, LLC |
| Q2 2014 | 42 | 1,342,913 | 13F-HR | 8/14/2014 | 000130692314000006 | Palo Alto Investors, LLC |
| Q1 2014 | 39 | 1,210,103 | NEW HOLDINGS | 5/16/2014 | 000130692314000004 | Palo Alto Investors, LLC |
| Q1 2014 | 35 | 1,208,816 | 13F-HR | 5/15/2014 | 000130692314000003 | Palo Alto Investors, LLC |
| Q4 2013 | 34 | 1,072,011 | 13F-HR | 2/13/2014 | 000114036114007018 | Palo Alto Investors, LLC |