| 
            Q2 2025
           | 
          26 | 
          153,801 | 
          
            
              IONS, RZLT, AMLX, LEGN
            
           | 
          
            13F-HR
           | 
          8/14/2025 | 
          000117266125003478 | 
        
        
          | 
            Q1 2025
           | 
          32 | 
          188,796 | 
          
            
              CYTK, KALV, EOLS, 2X10.SG
            
           | 
          
            13F-HR
           | 
          5/15/2025 | 
          000117266125002331 | 
        
        
          | 
            Q4 2024
           | 
          26 | 
          212,199 | 
          
            
              IONS, CYTK, KALV, VRDN
            
           | 
          
            13F-HR
           | 
          2/14/2025 | 
          000117266125001157 | 
        
        
          | 
            Q3 2024
           | 
          30 | 
          339,761 | 
          
            
              NGNE, 2X10.SG, PLRX, EOLS
            
           | 
          
            13F-HR
           | 
          11/13/2024 | 
          000117266124004656 | 
        
        
          | 
            Q2 2024
           | 
          33 | 
          522,016 | 
          
            
              URGN, NGNE, 2X10.SG, MRUS
            
           | 
          
            13F-HR
           | 
          8/14/2024 | 
          000117266124003577 | 
        
        
          | 
            Q1 2024
           | 
          35 | 
          641,637 | 
          
            
              NGNE, ALPN, URGN, 2X10.SG
            
           | 
          
            13F-HR
           | 
          5/15/2024 | 
          000117266124002523 | 
        
        
          | 
            Q4 2023
           | 
          34 | 
          586,726 | 
          
            
              ALPN, CYTK, URGN, PLRX
            
           | 
          
            13F-HR
           | 
          2/14/2024 | 
          000117266124001436 | 
        
        
          | 
            Q3 2023
           | 
          42 | 
          549,036 | 
          
            
              URGN, ALPN, PLRX, PCVX
            
           | 
          
            13F-HR
           | 
          11/14/2023 | 
          000117266123004025 | 
        
        
          | 
            Q2 2023
           | 
          40 | 
          510,829 | 
          
            
              ALPN, RARE, PCVX, PLRX
            
           | 
          
            13F-HR
           | 
          8/14/2023 | 
          000117266123003165 | 
        
        
          | 
            Q1 2023
           | 
          44 | 
          509,321 | 
          
            
              PLRX, XENE, ALPN, RARE
            
           | 
          
            13F-HR
           | 
          5/15/2023 | 
          000117266123002293 | 
        
        
          | 
            Q4 2022
           | 
          42 | 
          510,185 | 
          
            
              PCVX, XENE, RAPT, ALPN
            
           | 
          
            13F-HR
           | 
          2/14/2023 | 
          000117266123001300 | 
        
        
          | 
            Q3 2022
           | 
          40 | 
          415,311 | 
          
            
              XENE, JAZZ, PNT, ALPN
            
           | 
          
            13F-HR
           | 
          11/14/2022 | 
          000117266122002573 | 
        
        
          | 
            Q2 2022
           | 
          35 | 
          416,964 | 
          
            
              XENE, JAZZ, CYTK, TVTX
            
           | 
          
            13F-HR
           | 
          8/15/2022 | 
          000117266122001993 | 
        
        
          | 
            Q1 2022
           | 
          30 | 
          413,781 | 
          
            
              EXEL, XENE, TVTX, BCYC
            
           | 
          
            13F-HR
           | 
          5/16/2022 | 
          000117266122001465 | 
        
        
          | 
            Q4 2021
           | 
          36 | 
          450,122 | 
          
            
              ARNA, EXEL, XENE, TVTX
            
           | 
          
            13F-HR
           | 
          2/14/2022 | 
          000117266122000487 | 
        
        
          | 
            Q3 2021
           | 
          36 | 
          429,472 | 
          
            
              EXEL, ARNA, KDMN, BCAB
            
           | 
          
            13F-HR
           | 
          11/15/2021 | 
          000117266121002382 | 
        
        
          | 
            Q2 2021
           | 
          30 | 
          476,717 | 
          
            
              MGNX, RCKT, ARNA, UTHR
            
           | 
          
            13F-HR
           | 
          8/16/2021 | 
          000117266121001868 | 
        
        
          | 
            Q1 2021
           | 
          28 | 
          483,855 | 
          
            
              MGNX, RCKT, IOVA, SAGE
            
           | 
          
            13F-HR
           | 
          5/17/2021 | 
          000117266121001313 | 
        
        
          | 
            Q4 2020
           | 
          33 | 
          615,668 | 
          
            
              GWPH, IOVA, SAGE, ACAD
            
           | 
          
            13F-HR
           | 
          2/16/2021 | 
          000117266121000726 | 
        
        
          | 
            Q3 2020
           | 
          34 | 
          1,111,643 | 
          
            
              IOVA, SAGE, ACAD, ARNA
            
           | 
          
            13F-HR
           | 
          11/16/2020 | 
          000117266120002326 | 
        
        
          | 
            Q2 2020
           | 
          36 | 
          1,251,009 | 
          
            
              CNST, IOVA, ZYMEWORKS INC, ACAD
            
           | 
          
            13F-HR
           | 
          8/14/2020 | 
          000117266120001861 | 
        
        
          | 
            Q1 2020
           | 
          36 | 
          957,136 | 
          
            
              ACAD, ZYMEWORKS INC, PTCT, IOVA
            
           | 
          
            13F-HR
           | 
          5/15/2020 | 
          000117266120001361 | 
        
        
          | 
            Q4 2019
           | 
          37 | 
          1,148,462 | 
          
            
              IOVA, ZYMEWORKS INC, PTCT, AXSM calls
            
           | 
          
            13F-HR
           | 
          2/14/2020 | 
          000117266120000830 | 
        
        
          | 
            Q3 2019
           | 
          41 | 
          1,088,642 | 
          
            
              IOVA, ZGNX, ACAD, BOLD
            
           | 
          
            13F-HR
           | 
          11/15/2019 | 
          000093041319002849 | 
        
        
          | 
            Q2 2019
           | 
          30 | 
          900,806 | 
          
            
              IOVA, PTCT, ZGNX, BOLD
            
           | 
          
            13F-HR
           | 
          8/14/2019 | 
          000093041319002313 | 
        
        
          | 
            Q1 2019
           | 
          40 | 
          1,010,320 | 
          
            
              PTCT, ZGNX, GLOBAL BLOOD THERAPEUTICS INC, BOLD
            
           | 
          
            13F-HR
           | 
          5/14/2019 | 
          000093041319001676 | 
        
        
          | 
            Q4 2018
           | 
          40 | 
          791,189 | 
          
            
              BCRX, IOVA, GLOBAL BLOOD THERAPEUTICS INC, XLRN
            
           | 
          
            13F-HR
           | 
          2/15/2019 | 
          000093041319000592 | 
        
        
          | 
            Q3 2018
           | 
          30 | 
          641,666 | 
          
            
              BCRX, XLRN, LRMR, IOVA
            
           | 
          
            13F-HR
           | 
          11/14/2018 | 
          000093041318003323 | 
        
        
          | 
            Q2 2018
           | 
          38 | 
          721,561 | 
          
            
              PTCT, KURA, IOVA, BCRX
            
           | 
          
            13F-HR
           | 
          8/14/2018 | 
          000093041318002592 | 
        
        
          | 
            Q1 2018
           | 
          37 | 
          673,402 | 
          
            
              IOVA, ARNA, KURA, PTCT
            
           | 
          
            13F-HR
           | 
          5/14/2018 | 
          000093041318001815 | 
        
        
          | 
            Q4 2017
           | 
          39 | 
          586,066 | 
          
            
              ZGNX, ARNA, KURA, SAGE
            
           | 
          
            13F-HR
           | 
          2/14/2018 | 
          000093041318000474 | 
        
        
          | 
            Q3 2017
           | 
          37 | 
          514,030 | 
          
            
              ZGNX, UTHR calls, ARNA, CNCE
            
           | 
          
            13F-HR
           | 
          11/14/2017 | 
          000093041317003778 | 
        
        
          | 
            Q2 2017
           | 
          38 | 
          558,190 | 
          
            
              ARNA, ADMS, VNDA, ZGNX
            
           | 
          
            13F-HR
           | 
          8/14/2017 | 
          000093041317002918 | 
        
        
          | 
            Q1 2017
           | 
          37 | 
          503,510 | 
          
            
              ADMS, CNCE, SGYPQ, VNDA
            
           | 
          
            13F-HR
           | 
          5/15/2017 | 
          000093041317002121 | 
        
        
          | 
            Q4 2016
           | 
          35 | 
          486,757 | 
          
            
              ADMS, FOMX, VNDA, SGYPQ
            
           | 
          
            13F-HR
           | 
          2/14/2017 | 
          000093041317000546 | 
        
        
          | 
            Q3 2016
           | 
          35 | 
          392,073 | 
          
            
              VNDA, ADMS, SGYPQ, ZGNX
            
           | 
          
            13F-HR
           | 
          11/14/2016 | 
          000093041316008703 | 
        
        
          | 
            Q2 2016
           | 
          39 | 
          349,225 | 
          
            
              ADMS, VNDA, SGYPQ, EXEL
            
           | 
          
            13F-HR
           | 
          8/15/2016 | 
          000093041316007885 | 
        
        
          | 
            Q1 2016
           | 
          33 | 
          278,668 | 
          
            
              ADMS, FPRX, VNDA, ZGNX
            
           | 
          
            13F-HR
           | 
          5/16/2016 | 
          000093041316007144 | 
        
        
          | 
            Q4 2015
           | 
          25 | 
          238,298 | 
          
            
              ADMS, FPRX, ZGNX, VNDA
            
           | 
          
            13F-HR
           | 
          2/16/2016 | 
          000093041316005528 | 
        
        
          | 
            Q3 2015
           | 
          36 | 
          252,823 | 
          
            
              VNDA, FPRX, CNXR, ADMS
            
           | 
          
            13F-HR
           | 
          11/16/2015 | 
          000093041315004329 | 
        
        
          | 
            Q2 2015
           | 
          34 | 
          256,525 | 
          
            
              CNXR, ADMS, VNDA, FPRX
            
           | 
          
            13F-HR
           | 
          8/14/2015 | 
          000093041315003355 | 
        
        
          | 
            Q1 2015
           | 
          33 | 
          227,217 | 
          
            
              CNXR, HPTX, VNDA, OFIX
            
           | 
          
            13F-HR
           | 
          5/15/2015 | 
          000093041315002517 | 
        
        
          | 
            Q4 2014
           | 
          28 | 
          207,762 | 
          
            
              CNXR, HPTX, ALIM, OCRX
            
           | 
          
            13F-HR
           | 
          2/17/2015 | 
          000093041315000640 | 
        
        
          | 
            Q3 2014
           | 
          37 | 
          232,821 | 
          
            
              HPTX, NBIX, INFI, ALIM
            
           | 
          
            13F-HR
           | 
          11/14/2014 | 
          000093041314004572 | 
        
        
          | 
            Q2 2014
           | 
          38 | 
          224,814 | 
          
            
              NBIX, HPTX, DSCI, THOR
            
           | 
          
            13F-HR
           | 
          8/14/2014 | 
          000093041314003671 | 
        
        
          | 
            Q1 2014
           | 
          36 | 
          191,481 | 
          
            
              FURX, HPTX, PAIN THERAPEUTICS INC, ALIM
            
           | 
          
            13F-HR
           | 
          5/15/2014 | 
          000093041314002534 | 
        
        
          | 
            Q4 2013
           | 
          28 | 
          141,604 | 
          
            
              HPTX, PAIN THERAPEUTICS INC, FURX, SUNSHINE HEART INC
            
           | 
          
            13F-HR
           | 
          2/14/2014 | 
          000093041314000601 |